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CAS 50924-49-7

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Mizoribine

Description:
Mizoribine, with the CAS number 50924-49-7, is an immunosuppressive agent primarily used in the treatment of autoimmune diseases and organ transplantation. It is a purine analog that inhibits the synthesis of nucleotides, thereby affecting lymphocyte proliferation and function. Mizoribine is characterized by its ability to selectively suppress T and B cell activity, making it valuable in preventing graft rejection and managing conditions like rheumatoid arthritis. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other immunosuppressants. Its mechanism of action involves the inhibition of inosine monophosphate dehydrogenase, which is crucial for the de novo synthesis of purines. Mizoribine is also noted for its pharmacokinetic properties, including its metabolism and excretion, which can vary among individuals. Overall, Mizoribine represents an important therapeutic option in the field of immunology and transplant medicine, contributing to improved patient outcomes in various clinical settings.
Formula:C9H13N3O6
InChI:InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
InChI key:InChIKey=HZQDCMWJEBCWBR-UUOKFMHZSA-N
SMILES:O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(O)=C(C(N)=O)N=C2
Synonyms:
  • 1H-Imidazole-4-carboxamide, 5-hydroxy-1-beta-D-ribofuranosyl-
  • 1H-Imidazole-4-carboxamide, 5-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
  • 4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate
  • 5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide
  • 5-Hydroxy-1-beta-D-ribofuranosylimidazole-4-carboxamide
  • 5-Hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-imidazole-4-carboxamide
  • 5-hydroxy-1-pentofuranosyl-1H-imidazole-4-carboxamide
  • Anhydro-4-carbamoyl-5-hydroxy-1-beta-D-ribofuranosyl-imidazolium hydroxide
  • Bredinin
  • Bredinine
  • See more synonyms
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