CAS 51-15-0

Pralidoxime chloride

Description:

Pralidoxime chloride, with the CAS number 51-15-0, is a chemical compound primarily used as an antidote for organophosphate poisoning, particularly in cases of nerve agent exposure. It functions by reactivating acetylcholinesterase, an enzyme inhibited by organophosphates, thus restoring normal neurotransmission. The compound is a quaternary ammonium salt, which contributes to its solubility in water and limits its ability to cross the blood-brain barrier. Pralidoxime chloride is typically administered via injection and is often used in conjunction with atropine to counteract the effects of cholinergic toxicity. Its chemical structure includes a pyridine ring and a hydroxyl group, which are essential for its reactivation mechanism. The substance is generally considered to have a low toxicity profile when used appropriately, but it can cause side effects such as muscle weakness or respiratory issues if misused. Proper storage and handling are crucial, as it should be kept in a cool, dry place away from incompatible substances.

Formula: C₇H₉N₂O·Cl

InChI: InChI=1S/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H

InChI key: InChIKey=HIGSLXSBYYMVKI-UHFFFAOYSA-N

SMILES: C(=NO)C=1[N+](C)=CC=CC1.[Cl-]

Synonyms:

• (E)-(1-methylpyridin-2(1H)-ylidene)-N-oxomethanaminium chloride
• 1-Methyl-2-aldoximinopyridinium chloride
• 1-Methylpyridinium-2-aldoxime chloride
• 2-Formyl-1-methylpyridinium chloride oxime
• 2-Hydroxyiminomethyl-1-Methylpyridinium Chloride
• 2-PAM chloride
• 2-Pralidoxime chloride
• 2-[(E)-(hydroxyimino)methyl]-1-methylpyridinium chloride
• 2-[(Hydroxyimino)methyl]-1-methylpyridin-1-ium chloride
• N-Methylpyridinium-2-aldoxime chloride
• N-Methylpyridinium-2-carboxaldoxime chloride
• Pralidoxime chloride
• Protopam chloride
• Pyraloxime Methylchloride
• Pyridine-2-aldoxime methochloride
• Pyridine-2-carbaldoxime methochloride
• Pyridinium, 2-[(hydroxyimino)methyl]-1-methyl-, chloride
• Pyridinium, 2-[(hydroxyimino)methyl]-1-methyl-, chloride (1:1)
• Pyridinium, 2-formyl-1-methyl-, chloride, oxime

1-Methylpyridinium-2-aldoxime Chloride

CAS: 51-15-0

Formula: C₇H₉ClN₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 172.61

Ref: 3B-M0819

Pyridine-2-carboxaldoxime methochloride, 97%

CAS: 51-15-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₇H₉ClN₂O

Purity: 97%

Color and Shape: Crystals or powder or crystalline powder or fused/lumpy solid, White to pale cream

Molecular weight: 172.61

Ref: 02-B23890

Pralidoxime Chloride

CAS: 51-15-0

Pralidoxime Chloride (2-PAM chloride) is a agent in the treatment of organophosphate poisoning, which binds to organophosphate-inactivated acetylcholinesterase.

Formula: C₇H₉ClN₂O

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 172.61

Ref: TM-T1111

1-​Methylpyridinium-​2-​aldoxime chloride

CAS: 51-15-0

Formula: C₇H₉ClN₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 172.6122

Ref: IN-DA003HX2

Pyridine-2-aldoxime methochloride

CAS: 51-15-0

Formula: C₇H₉N₂O·Cl

Purity: ≥ 98.0%

Color and Shape: White to off-white or light yellow crystalline powder

Molecular weight: 172.61

Ref: 7W-GE1467

Pralidoxime Chloride

CAS: 51-15-0

Pralidoxime Chloride

Purity: ≥98%

Molecular weight: 172.61g/mol

Ref: 54-BUP17362

2-((Hydroxyimino)Methyl)-1-Methylpyridin-1-Ium Chloride

CAS: 51-15-0

2-((Hydroxyimino)Methyl)-1-Methylpyridin-1-Ium Chloride

Purity: 99%

Molecular weight: 172.61g/mol

Ref: 54-OR1009629

Pralidoxime Chloride

CAS: 51-15-0

Color and Shape: Neat

Ref: 86-MM1067.00

Pralidoxime Chloride

CAS: 51-15-0

Formula: C₇H₉N₂O·Cl

Molecular weight: 137.16 35.45

Ref: 4Z-P-253001

Pralidoxime Chloride

Controlled Product

CAS: 51-15-0

Applications This compound binds to inactivated acetylcholinesterases and is used to combat poisoning from organophosphates and nerve agents
References Lajmanovich, R., et al.: Toxicol. Env. Chem., 90, 1145 (2008), Eyer, P., et al.: Brit. J. Clin. Pharmacol., 66, 450 (2008), Goncalves, L., et al.: J. Pharm. Sci., 98, 1040 (2009),

Formula: C₇H₉N₂O·Cl

Color and Shape: White Solid

Molecular weight: 172.61

Ref: TR-P701120

Pralidoxime chloride - Bio-X ™

CAS: 51-15-0

Pralidoxime is a cholinesterase reactivator that is used for the treatment of organophosphate poisoning. When organophosphate binds to the esteratic site of acetylcholinesterase, it results in a reversible inactivation of the enzyme. However, by rupturing the phosphate-ester link that has been formed between the organophosphate and acetylcholinesterase, pralidoxime is able to reactivate the cholinesterase enzyme.

Formula: C₇H₉ClN₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 172.61 g/mol

Ref: 3D-BP164283

Pralidoxime chloride

CAS: 51-15-0

Reactivates acetylcholinesterases; treats organophosphate poisoning

Formula: C₇H₉ClN₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 172.61 g/mol

Ref: 3D-FP27115

2-[(1E)-(hydroxyimino)methyl]-1-methylpyridin-1-ium chloride

CAS: 51-15-0

Formula: C₇H₉ClN₂O

Purity: ≥98%(HPLC)

Molecular weight: 172.61

Ref: 10-F358359

Pralidoxime Chloride

CAS: 51-15-0

Formula: C₇H₉N₂OCl

Molecular weight: 137.16 : 35.45

Ref: ST-EA-CP-P187001