CAS 5142-23-4

3-Methyladenine

Description:

3-Methyladenine is a purine derivative and a structural analog of adenine, characterized by the presence of a methyl group at the nitrogen atom in the 3-position of the adenine ring. Its molecular formula is C6H8N4O2, and it has a molecular weight of approximately 168.16 g/mol. This compound is known for its role in various biological processes, particularly in the context of DNA repair and cellular signaling. 3-Methyladenine can act as an inhibitor of certain enzymes, such as phosphoinositide 3-kinase, and has been studied for its potential implications in cancer research and therapeutic applications. In terms of physical properties, it is typically a white to off-white crystalline solid, soluble in water and organic solvents. The compound is also of interest in the field of biochemistry due to its involvement in the regulation of autophagy and its potential effects on cellular metabolism. As with many chemical substances, proper handling and safety precautions should be observed when working with 3-Methyladenine.

Formula: C₆H₇N₅

InChI: InChI=1/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

InChI key: InChIKey=FSASIHFSFGAIJM-UHFFFAOYSA-N

SMILES: NC1=C2C(N(C)C=N1)=NC=N2

Synonyms:

• 3-Ma
• 3-Methyl-3H-purin-6-ylamine
• 3-Methyl-6-aminopurine
• 3-Methyladenine
• 3-Methylpurin-6-amine
• 3-methyl-3H-purin-6-amine
• 3H-Purin-6-amine, 3-methyl-
• 6-Amino-3-methylpurine
• Adenine, 3-methyl-
• Brn 0146087
• N³-Methyladenine
• Nsc 66389
• 5-26-17-00151 (Beilstein Handbook Reference)
• 3-Methyl-3H-adenine
• N3-Methyladenine
• NSC 66389,3-M
• 3-Methyladenine6-Amino-3-methylpurine
• 3-Methyladenine, pure
• 3-methyl-3h-purin-6-amin
• Autophagy Inhibitor, 3-MA
• 3-Methyl-6-amino-3H-purine
• 3-methyl-adenin
• NSC 66389,3-MA
• 3-Methyladenine, 90+%, pure
• 3-MA (3-Methyl adenine)
• 3-methyladenine,3MA
• 3-Methyladenine, pure, 90+%
• 3-Methyladenine, GC 90+%

3-Methyladenine

CAS: 5142-23-4

Formula: C₆H₇N₅

Purity: min. 98.0 area%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 149.16

Ref: 3B-M2518

3-Methyl-3H-purin-6-amine

CAS: 5142-23-4

Formula: C₆H₇N₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 149.1533

Ref: IN-DA006W7H

3-Methyladenine

CAS: 5142-23-4

3-Methyladenine

Purity: ≥98%

Molecular weight: 149.15g/mol

Ref: 54-BUP15785

3-Methyladenine

CAS: 5142-23-4

3-Methyladenine

Formula: C₆H₇N₅

Purity: ≥95%

Color and Shape: off-white solid

Molecular weight: 149.15g/mol

Ref: 54-OR470734

3-Methyladenine

CAS: 5142-23-4

3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).

Formula: C₆H₇N₅

Purity: 98% - 99.51%

Color and Shape: Solid

Molecular weight: 149.15

Ref: TM-T1879

3-Methyladenine autophagy inhibitor

CAS: 5142-23-4

Formula: C₆H₇N₅

Purity: ≥ 98.0%

Color and Shape: White solid

Molecular weight: 149.15

Ref: 7W-GL3599

3-Methyl Adenine

CAS: 5142-23-4

Formula: C₆H₇N₅

Molecular weight: 149.16

Ref: 4Z-A-375001

3-Methyl Adenine

CAS: 5142-23-4

Applications 3-Methyl Adenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor (1,2,3). 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).
References (1) Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001) (2) Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006) (3) Hayat, M., et al.: Oncologist, 12, 20 (2007)

Formula: C₆H₇N₅

Color and Shape: White Solid

Molecular weight: 149.15

Ref: TR-M275904

3-Methyladenine

CAS: 5142-23-4

3-Methyladenine is a glycosylase that cleaves the glycosidic bond between the 3rd and 4th carbon of the ribose ring of the nucleotide 3-methyladenine. It also has synergistic effects with other agents that induce autophagy, such as rapamycin, and increases the expression of a response element in mouse monoclonal antibody. 3-Methyladenine inhibits growth factor-β1 and neuronal death by inducing apoptosis in cells overexpressing nuclear DNA polymerase. This drug is also used to study apoptosis by using a model system.

Formula: C₆H₇N₅

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 149.15 g/mol

Ref: 3D-FM08029

3-Methyl-3H-purin-6-amine

CAS: 5142-23-4

Formula: C₆H₇N₅

Purity: 98%

Color and Shape: No data available.

Molecular weight: 149.157

Ref: 10-F216595

3-Methyl Adenine

CAS: 5142-23-4

Formula: C₆H₇N₅

Molecular weight: 149.16

Ref: ST-EA-CP-A352001