CAS 51596-11-3
:Milbemycin A4
Description:
Milbemycin A4 is a macrocyclic lactone compound that belongs to the milbemycin class of antibiotics, primarily known for its use as an antiparasitic agent. It is derived from the fermentation of the bacterium *Streptomyces hygroscopicus*. This compound exhibits potent activity against a variety of nematodes and arthropods, making it valuable in veterinary medicine, particularly for treating parasitic infections in livestock and pets. Milbemycin A4 functions by interfering with the transmission of nerve impulses in parasites, leading to paralysis and death. The substance is characterized by its lipophilic nature, which enhances its bioavailability and efficacy. It is typically administered in formulations that ensure optimal absorption and therapeutic effect. Safety profiles indicate that it has a low toxicity to mammals, which contributes to its favorable use in veterinary applications. However, like all pharmaceuticals, it should be used according to prescribed guidelines to minimize the risk of resistance development in target parasites.
Formula:C32H46O7
InChI:InChI=1/C32H46O7/c1-6-27-21(4)12-13-31(39-27)17-25-16-24(38-31)11-10-20(3)14-19(2)8-7-9-23-18-36-29-28(33)22(5)15-26(30(34)37-25)32(23,29)35/h7-10,15,19,21,24-29,33,35H,6,11-14,16-18H2,1-5H3/b8-7+,20-10+,23-9-/t19?,21?,24-,25+,26+,27?,28-,29-,31-,32-/m1/s1
InChI key:InChIKey=VOZIAWLUULBIPN-LRBNAKOISA-N
SMILES:C(C)[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/C[C@@H](C)/C=C/C=C\4/[C@@]5(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]5(OC4)[H])[H])[H])[H])CC[C@@H]1C
Synonyms:- Milbemycin α3
- Spiro[11,15-methano-2H,7H,13H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], milbemycin B deriv.
- (6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-ethylmilbemycin B
- Antibiotic B 41A4
- Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-, (6R,25R)-
- (25R)-25-Ethyl-5β-hydroxy-5-demethoxy-28-O,6β-cyclomilbemycin B
- milbemectine a4
- B 41A4, MilbeMycin alpha3
- VOZIAWLUULBIPN-WMKNSKLVSA-N
- Milbemycin EP Imp A
- MILBEMECTIN A4
- Milbemycin Impurity 1(Milbemycin EP Impurity A)
- milbemycin A4
- Milbemycin oxime A4
- milbemycinb-1
- See more synonyms
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Found 8 products.
Milbemycin A4
CAS:<p>Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.</p>Formula:C32H46O7Color and Shape:SolidMolecular weight:542.713Milbemectin A4 10 µg/mL in Acetonitrile
CAS:Formula:C32H46O7Color and Shape:Single SolutionMolecular weight:542.70Milbemectin A4
CAS:<p>Milbemectin A4 is a drug that belongs to the class of anthelmintic drugs. It is a mixture of moxidectin, which is a macrocyclic lactone, and milbemycin oxime. Milbemectin A4 has been shown to be effective against wild-type strains of C. glabrata in experimental models. This drug has also been shown to cause liver lesions in rats and humans, although the exact mechanism of action remains unknown. This drug may inhibit the uptake of milbemycin by P-glycoprotein (Pgp) in the human blood stream and increase its concentration in the blood plasma. The analytical method for quantifying milbemycin oxime in plasma samples involves extracting the sample with chloroform/methanol followed by liquid chromatography with UV detection at 254 nm.</p>Formula:C32H46O7Purity:85%NmrColor and Shape:PowderMolecular weight:542.7 g/mol
