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CAS 51596-11-3

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Milbemycin A4

Description:
Milbemycin A4 is a macrocyclic lactone compound that belongs to the milbemycin class of antibiotics, primarily known for its use as an antiparasitic agent. It is derived from the fermentation of the bacterium *Streptomyces hygroscopicus*. This compound exhibits potent activity against a variety of nematodes and arthropods, making it valuable in veterinary medicine, particularly for treating parasitic infections in livestock and pets. Milbemycin A4 functions by interfering with the transmission of nerve impulses in parasites, leading to paralysis and death. The substance is characterized by its lipophilic nature, which enhances its bioavailability and efficacy. It is typically administered in formulations that ensure optimal absorption and therapeutic effect. Safety profiles indicate that it has a low toxicity to mammals, which contributes to its favorable use in veterinary applications. However, like all pharmaceuticals, it should be used according to prescribed guidelines to minimize the risk of resistance development in target parasites.
Formula:C32H46O7
InChI:InChI=1/C32H46O7/c1-6-27-21(4)12-13-31(39-27)17-25-16-24(38-31)11-10-20(3)14-19(2)8-7-9-23-18-36-29-28(33)22(5)15-26(30(34)37-25)32(23,29)35/h7-10,15,19,21,24-29,33,35H,6,11-14,16-18H2,1-5H3/b8-7+,20-10+,23-9-/t19?,21?,24-,25+,26+,27?,28-,29-,31-,32-/m1/s1
InChI key:InChIKey=VOZIAWLUULBIPN-LRBNAKOISA-N
SMILES:C(C)[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/C[C@@H](C)/C=C/C=C\4/[C@@]5(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]5(OC4)[H])[H])[H])[H])CC[C@@H]1C
Synonyms:
  • Milbemycin α3
  • Spiro[11,15-methano-2H,7H,13H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], milbemycin B deriv.
  • (6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-ethylmilbemycin B
  • Antibiotic B 41A4
  • Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-, (6R,25R)-
  • (25R)-25-Ethyl-5β-hydroxy-5-demethoxy-28-O,6β-cyclomilbemycin B
  • milbemectine a4
  • B 41A4, MilbeMycin alpha3
  • VOZIAWLUULBIPN-WMKNSKLVSA-N
  • Milbemycin EP Imp A
  • See more synonyms
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