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CAS 51805-45-9

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Tris-(2-carboxyethyl)-phosphine hydrochloride

Description:
Tris-(2-carboxyethyl)-phosphine hydrochloride, commonly referred to as TCEP hydrochloride, is a water-soluble phosphine compound with the CAS number 51805-45-9. It is characterized by its ability to act as a reducing agent, particularly in biochemical applications, where it is often used to maintain proteins in their reduced state by preventing oxidation. TCEP hydrochloride is stable under a wide range of pH conditions and does not react with thiol groups, making it a preferred choice over other reducing agents like dithiothreitol (DTT) or β-mercaptoethanol, which can introduce unwanted side reactions. The compound is typically supplied as a white to off-white crystalline powder and is soluble in water, allowing for easy incorporation into various biochemical assays. Additionally, TCEP hydrochloride is non-toxic and does not have the unpleasant odor associated with some other reducing agents, enhancing its usability in laboratory settings. Its unique properties make it valuable in protein chemistry, particularly in studies involving disulfide bond reduction and protein folding.
Formula:C9H12O6P
InChI:InChI=1/C9H15O6P/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15/h1-6H2,(H,10,11)(H,12,13)(H,14,15)/p-3
SMILES:C(CP(CCC(=O)[O-])CCC(=O)[O-])C(=O)[O-]
Synonyms:
  • 3,3',3''-Phosphanetriyltripropanoic Acid Hydrochloride
  • 3,3',3''-Phosphanetriyltripropanoate
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