CAS 51833-78-4

angiotensin fragment 1-7 human acetate

Description:

Angiotensin fragment 1-7, also known as angiotensin 1-7 or A-1-7, is a peptide that plays a crucial role in the renin-angiotensin system, which regulates blood pressure and fluid balance. This fragment is derived from the cleavage of angiotensin II and is known for its vasodilatory effects, promoting cardiovascular health by counteracting the actions of angiotensin II. The acetate form indicates that the peptide is in a salt form, which can enhance its stability and solubility. Characteristically, angiotensin 1-7 exhibits biological activity through its interaction with the Mas receptor, leading to various physiological effects, including anti-inflammatory and anti-fibrotic actions. It is often studied for its potential therapeutic applications in conditions such as hypertension, heart failure, and kidney disease. The CAS number 51833-78-4 uniquely identifies this specific peptide, facilitating its recognition in scientific literature and databases. Overall, angiotensin fragment 1-7 is a significant biomolecule with implications in cardiovascular physiology and potential clinical applications.

Formula: C₄₁H₆₂N₁₂O₁₁

InChI: InChI=1/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](C(C)C)N=C([C@H](CCCNC(=N)N)N=C([C@H](CC(=O)O)N)O)O)O)O

Synonyms:

• Angiotensin I/II (1-7)
• H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH
• L-alpha-aspartyl-N~5~-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline

Angiotensin I/II (1-7)

CAS: 51833-78-4

Angiotensin (1-7), DRVYIHP, an enzymatically produced peptide of the renin-angiotensin system, shows pharmacologically distinct, tissue-specific actions that differ from those of angiotensin II. Angiotensin (1-7) shows considerable cardiovascular and antiangiogenic activity. Iusuf et al. reviewed its phamacological properties and pharmacotherapeutic perspectives. Moreover, the heptapeptide was shown to inhibit the growth of human lung cancer cells in vitro and to reduce the size of human lung cancer xenografts in vivo.

Formula: C₄₁H₆₂N₁₂O₁₁

Purity: 99.3%

Color and Shape: White Powder

Molecular weight: 899.02

Ref: 01-4006081

ASP-ARG-VAL-TYR-ILE-HIS-PRO

CAS: 51833-78-4

Formula: C₄₁H₆₂N₁₂O₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 899.0048

Ref: IN-DA00D884

Angiotensin (1-7)

CAS: 51833-78-4

Angiotensin (1-7)

Purity: ≥98%

Molecular weight: 899g/mol

Ref: 54-BUP02118

Angiotensin (1-7) acetate salt hydrate

CAS: 51833-78-4

Molecular weight: 899.00 (anhydrous)

Ref: 7W-GM0621

Angiotensin I (1-7)

CAS: 51833-78-4

Formula: C₄₁H₆₂N₁₂O₁₁

Molecular weight: 899.02

Ref: 4Z-A-258001

Angiotensin (1-7)

CAS: 51833-78-4

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide, inhibits canine ACE activity with vasodilator and antiproliferative activities.

Formula: C₄₁H₆₂N₁₂O₁₁

Purity: >99.99%

Color and Shape: White Lyophilised Solid

Molecular weight: 899

Ref: TM-T7339

Angiotensin, Canine, Rat

CAS: 51833-78-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₄₁H₆₂N₁₂O₁₁

Molecular weight: 899 g/mol

Ref: 3D-PP50386

Angiotensin (Human, 1-7)

CAS: 51833-78-4

Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang-(1-7) directly from angiotensin I (Ang-I).Ang-(1-7) broadly opposes Ang-II actions. Ang-(1-7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang-(1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.

Formula: C₄₁H₆₂N₁₂O₁₁

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 899.01 g/mol

Ref: 3D-CRB1000803

Angiotensin (1-7) xTFA salt

Controlled Product

CAS: 51833-78-4

Applications Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.
References Verlackt, C., et al.: J Phys Chem C, 121, 5787 (2017)

Formula: C₄₁H₆₂N₁₂O₁₁·xTFA

Color and Shape: Neat

Molecular weight: 899.00 + x(114.02)

Ref: TR-A637945

Angiotensin (Human, 1-7)

CAS: 51833-78-4

Angiotensin (Human, 1-7) is a peptide hormone that is produced in the body by the renin-angiotensin system. This peptide hormone helps to regulate blood pressure and blood volume. Angiotensin (Human, 1-7) works by activating both receptors on cells, which causes vasoconstriction and stimulates the release of aldosterone from the adrenal gland. Angiotensin (Human, 1-7) can also stimulate various ion channels and cause vasoconstriction. The antibody against this peptide may be used as a research tool for studying its function in cell biology or as an inhibitor or activator in pharmacology.

Formula: C₄₁H₆₂N₁₂O₁₁•CH₃COOH•4H₂O

Purity: Min. 95%

Molecular weight: 1,031.11 g/mol

Ref: 3D-PAN-4332

Angiotensin (Human, 1-7)

CAS: 51833-78-4

Angiotensin (human, 1-7) is a peptide that acts as an agonist for the angiotensin II receptor. It is used in research as a pharmacological tool and in cell biology to study protein interactions and signaling pathways. It is also used to study the role of angiotensin receptors in various diseases such as hypertension and heart disease. Angiotensin (human, 1-7) is supplied at high purity and without any contaminants.

Formula: C₄₁H₆₂N₁₂O₁₁

Purity: Min. 95%

Molecular weight: 899 g/mol

Ref: 3D-PAN-4332-V

Angiotensin I/II (1-7) trifluoroacetate salt

CAS: 51833-78-4

Angiotensin I/II (1-7) trifluoroacetate salt is a selective inhibitor of angiotensin II. It blocks the activity of angiotensin II, and thereby prevents the activation of growth factor-β1, which leads to a decrease in pulmonary hypertension. The drug has also been shown to be effective in blocking dextran sulfate absorption, as well as preventing bowel disease by inhibiting receptor activity. Angiotensin I/II (1-7) trifluoroacetate salt has been shown to have an anti-inflammatory effect on the cardiovascular system by blocking cell signaling pathways and reducing blood pressure. This drug is used for treatment of metabolic disorders such as atherosclerotic lesion, cardiac diseases such as coronary heart diseases, and bowel disease.

Formula: C₄₁H₆₂N₁₂O₁₁

Purity: Min. 95%

Molecular weight: 899.01 g/mol

Ref: 3D-FA108515