Description:Ellipticine is a naturally occurring alkaloid derived from the leaves of the plant genus Ochrosia, known for its potential anticancer properties. It has a complex polycyclic structure, characterized by a fused indole and quinoline system, which contributes to its biological activity. Ellipticine exhibits a range of pharmacological effects, primarily as an antitumor agent, by intercalating into DNA and inhibiting topoisomerase II, thereby disrupting DNA replication and transcription. This compound is typically found as a pale yellow to orange crystalline solid and is sparingly soluble in water but more soluble in organic solvents. Its chemical formula is C15H13N, and it has a molecular weight of approximately 223.27 g/mol. In addition to its anticancer properties, ellipticine has shown potential in treating other conditions, including viral infections. However, its use is often limited by toxicity and side effects, necessitating further research to optimize its therapeutic applications and minimize adverse effects.
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