CAS 52214-84-3

Ciprofibrate

Description:

Ciprofibrate is a synthetic compound classified as a fibrate, primarily used in the management of dyslipidemia, particularly to lower triglyceride levels and increase high-density lipoprotein (HDL) cholesterol. Its chemical structure features a phenoxy group and a carboxylic acid moiety, contributing to its lipid-modulating properties. The substance is known for its ability to activate peroxisome proliferator-activated receptors (PPARs), which play a crucial role in lipid metabolism. Ciprofibrate is typically administered orally and is well-absorbed in the gastrointestinal tract. It exhibits a moderate half-life, allowing for once or twice daily dosing. The compound is generally well-tolerated, though potential side effects may include gastrointestinal disturbances and muscle-related issues. As with other fibrates, it is important to monitor liver function and muscle enzyme levels during treatment. Ciprofibrate is often used in conjunction with lifestyle modifications and other lipid-lowering agents to achieve optimal therapeutic outcomes in patients with elevated lipid levels.

Formula: C₁₃H₁₄Cl₂O₃

InChI: InChI=1/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

InChI key: InChIKey=KPSRODZRAIWAKH-UHFFFAOYSA-N

SMILES: ClC1(Cl)C(C1)C2=CC=C(OC(C(O)=O)(C)C)C=C2

Synonyms:

• 2-(4-(2,2-Dichlorocyclopropyl)phenoxy)2-methylpropanoic acid
• 2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid
• 2-[4-(2,2-Dichloro-cyclopropyl)-phenoxy]-2-methyl-propionic acid
• Brn 1984981
• Ccris 173
• Ciprofibrato
• Ciprofibrato [INN-Spanish]
• Ciprofibratum
• Ciprofibratum [INN-Latin]
• Ciprol
• Lipanor
• Modalim
• Propanoic acid, 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl-
• Unii-F8252Jgo9S
• Win 35833
• Ciprofibrate
• 2-(p-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropionicacid
• Cipml
• 2-[4-(2，2-Dichlom-cyclopropyl)phenoxy]-2-methy|propanoic acid
• 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl-propionicaci
• Ciprofibric acid
• 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl-propanoicaci
• 2-[P-(2,2-DICHLOROCYCLOPROPYL)-PHENOXY]-2-METHYLPROPANOIC ACID

Ciprofibrate

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 289.15

Ref: 3B-C2667

Ciprofibrate impurity standard

CAS: 52214-84-3

Ciprofibrate impurity standard

Color and Shape: White

Ref: 47-1312

CIPROFIBRATE FOR SYSTEM SUITABILITY B CRS

CAS: 52214-84-3

CIPROFIBRATE FOR SYSTEM SUITABILITY B CRS

Ref: 41-Y0002450

CIPROFIBRATE CRS

CAS: 52214-84-3

CIPROFIBRATE CRS

Formula: C₁₃H₁₄Cl₂O₃

Color and Shape: Crystalline Powder. White. Whitish. Powder.

Molecular weight: 289.1545

Ref: 41-Y0000362

Ciprofibrate

CAS: 52214-84-3

Ciprofibrate

Formula: C₁₃H₁₄Cl₂O₃

Purity: 99.9%

Color and Shape: White

Molecular weight: 288.032

Ref: 47-1278

Ciprofibrate

CAS: 52214-84-3

Ciprofibrate

Formula: C₁₃H₁₄Cl₂O₃

Purity: 99.5%

Molecular weight: 289.15

Ref: 54-BUP16708

Ciprofibrate

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Color and Shape: Off-White Solid

Molecular weight: 289.15

Ref: 4Z-C-681

Ciprofibrate

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Purity: ≥ 98.0%

Color and Shape: White to light-yellow powder or crystals

Molecular weight: 289.15

Ref: 7W-GP0375

2-(4-(2,2-Dichlorocyclopropyl)Phenoxy)-2-Methylpropanoic Acid

CAS: 52214-84-3

2-(4-(2,2-Dichlorocyclopropyl)Phenoxy)-2-Methylpropanoic Acid

Formula: C₁₃H₁₄Cl₂O₃

Purity: 98%

Molecular weight: 289.15

Ref: 54-OR1009741

Ciprofibrate

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 289.1545

Ref: IN-DA00I9CC

Ciprofibrate

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Color and Shape: Neat

Molecular weight: 289.15

Ref: 61-FOR1141.00

Ciprofibrate

Controlled Product

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Color and Shape: Neat

Molecular weight: 289.15

Ref: 86-MM1141.00

Ciprofibrate

Controlled Product

CAS: 52214-84-3

Applications Ciprofibrate is a hypolipemic agent, related structurally to Clofibrate (C586910). Ciprofibrate is used as an antilipemic.
References Davison, C., et al.: Drug. Metab. Dispos., 3, 520 (1975), Arnold, A., et al.: J. Pharm. Sci., et al.: 68, 1557 (1979), Tuchman-Duplessis, H., et al.: Toxicology, 12, 1 (1979),

Formula: C₁₃H₁₄Cl₂O₃

Color and Shape: Neat

Molecular weight: 289.15

Ref: TR-C482475

Ciprofibrate

CAS: 52214-84-3

Ciprofibrate (Win35833) is a fibrate derivative with antilipidemic activity.

Formula: C₁₃H₁₄Cl₂O₃

Purity: 99.63% - >99.99%

Color and Shape: White Or Almost White Crystalline Powder

Molecular weight: 289.15

Ref: TM-T1264

2-(4-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid

CAS: 52214-84-3

2-(4-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid

Formula: C₁₃H₁₄Cl₂O₃

Purity: 98%

Molecular weight: 289.15

Ref: IN-DG121411

Ciprofibrate - Bio-X ™

CAS: 52214-84-3

Ciprofibrate is a fibrate drug that is used as a lipid-lowering agent. This drug reduces both LDL and VLDL cholesterol levels in the blood. Ciprofibrate works by reducing the production of triglycerides in the liver and increasing the removal of triglycerides from the blood. This drug is an agonist of peroxisome proliferator-activated receptor alpha.

Formula: C₁₃H₁₄Cl₂O₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 289.15 g/mol

Ref: 3D-BD164311

2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

CAS: 52214-84-3

2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid (CGP) is a drug that blocks the nuclear receptor PPARγ. It has been shown to reduce cholesterol levels by inhibiting the synthesis of cholesterol, as well as reducing liver lesions in vivo. CGP also inhibits the growth of cancer cells through its ability to bind to DNA and regulate transcriptional activity. The response element for this compound is found in the promoter region of the gene encoding the growth factor-β1 (GF-β1), which is an important regulator of cell proliferation, differentiation, and apoptosis. CGP also inhibits peroxisome proliferator activator receptor α (PPARα) and γ (PPARγ). This inhibition leads to decreased expression of genes involved in lipid metabolism, such as acyl CoA synthase and fatty acid synthetase. CGP has also been shown to be carcinogenic in vivo

Formula: C₁₃H₁₄Cl₂O₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 289.15 g/mol

Ref: 3D-FD11320

Ciprofibrate

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Molecular weight: 289.15

Ref: BE-RMCC263000

2-(4-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 289.15

Ref: 10-F212903

Ciprofibrate

CAS: 52214-84-3

Formula: C₁₃H₁₄Cl₂O₃

Molecular weight: 289.15

Ref: ST-EA-CP-C77000