CAS 52950-18-2

(-)-2-Chloromandelic acid

Description:

(-)-2-Chloromandelic acid is an organic compound characterized by its chiral structure, featuring a chlorinated aromatic ring and a carboxylic acid functional group. It is a derivative of mandelic acid, where a chlorine atom is substituted at the second position of the benzene ring. This compound typically appears as a white to off-white crystalline solid and is soluble in polar solvents such as water and alcohols. Its chirality imparts specific optical activity, making it significant in various applications, particularly in pharmaceuticals and organic synthesis. The presence of the carboxylic acid group contributes to its acidity and reactivity, allowing it to participate in various chemical reactions, including esterification and amidation. Additionally, (-)-2-Chloromandelic acid can serve as an intermediate in the synthesis of other complex molecules, highlighting its importance in medicinal chemistry and the development of chiral drugs. Safety data should be consulted for handling and storage, as with all chemical substances.

Formula: C₈H₇ClO₃

InChI: InChI=1/C8H7ClO3/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7,10H,(H,11,12)/t7-/m0/s1

InChI key: InChIKey=RWOLDZZTBNYTMS-SSDOTTSWSA-N

SMILES: [C@@H](C(O)=O)(O)C1=C(Cl)C=CC=C1

Synonyms:

• (-)-2-Chloromandelic acid
• (2R)-(2-chlorophenyl)(hydroxy)ethanoic acid
• (2R)-2-(2-Chlorophenyl)-2-(hydroxy)acetic acid
• (2S)-(2-chlorophenyl)(hydroxy)ethanoic acid
• (R)-(-)-2-Hydroxy-2-(2-chlorophenyl)acetic acid
• (R)-(2-Chlorophenyl)(hydroxy)acetic acid
• (R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid
• (R)-2-(2-Chlorophenyl)-2-hydroxyethanoic acid
• (R)-o-Chloromandelic acid
• (αR)-2-Chloro-α-hydroxybenzeneacetic acid
• Benzeneacetic acid, 2-chloro-α-hydroxy-, (R)-
• Benzeneacetic acid, 2-chloro-α-hydroxy-, (αR)-
• D-(-)-2-Chloromandelic acid
• R-2-Chloromandelic Acid
• (R)-2-Chloromandelic acid
• R-(-)-2-Chloromandelic acid
• R-Chloromadelic acid
• 2-CHLORO-D-MANDELIC ACID
• (R )-(-)-2-chloromandellic acid
• (R)-(-)-2-CHLOROMANDELIC ACID 99%
• (R-chloromandelicacid)
• (R)-2-CHLORO-ALPHA-HYDROXYPHENYLACETIC ACID
• (R)-(-)-2-CHLOROMANDELIC ACID: CHIPROS 99%, EE 99%
• (R)-ORTHO-CHLOROMANDELIC ACID
• (R)-(-)-2-Chloromandelic acid, ChiPros 99+%, ee 99+%
• (2R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid
• (r)-2-chloro-à-hydroxyphenylacetic acid
• (R)-(−
• (R)-(2-CHLORO-PHENYL)-HYDROXY-ACETIC ACID
• 2-CHLORO-MANDELIC ACID (R)
• (-)-o-Chloro-D-mandelic acid

2-Chloro-D-mandelic Acid

CAS: 52950-18-2

Formula: C₈H₇ClO₃

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 186.59

Ref: 3B-C1663

(R)-(-)-2-Chloromandelic acid, ChiPros 99+%, ee 99+%

CAS: 52950-18-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₇ClO₃

Purity: 99+%

Color and Shape: White, crystalline powder

Molecular weight: 186.59

Ref: 02-L19586

(R)-(-)-2-Chloromandelic acid

CAS: 52950-18-2

Formula: C₈H₇ClO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 186.5924

Ref: IN-DA003C2Q

(R)-(-)-2-Chloromandelic acid

CAS: 52950-18-2

Formula: C₈H₇ClO₃

Purity: ≥ 99.0%

Color and Shape: White to light yellow crystalline powder

Molecular weight: 186.60

Ref: 7W-GK8180

(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid

CAS: 52950-18-2

(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid

Formula: C₈H₇ClO₃

Purity: 98%

Molecular weight: 186.59

Ref: IN-DG11030

(R)-(-)-2-Chloromandelic acid

CAS: 52950-18-2

(R)-(-)-2-Chloromandelic acid

Formula: C₈H₇ClO₃

Purity: >98%

Molecular weight: 186.59238

Ref: 54-OR315005

(R)-2-Chloromandelic acid

CAS: 52950-18-2

Formula: C₈H₇ClO₃

Purity: 98%

Color and Shape: Solid, Flakes

Molecular weight: 186.59

Ref: 10-F011644

(R)-(-)-2-Chloromandelic Acid

Controlled Product

CAS: 52950-18-2

Applications Clopidogrel intermediate.
References Zhu, Shou-Fei; C., et al.: Nat. Chem., 2, 546 (2010), Sun, Y. et al.: Acta. Crys. Sec. E. Struct. Rep. On., E63, o2379 (2007);

Formula: C₈H₇ClO₃

Color and Shape: Neat

Molecular weight: 186.59

Ref: TR-C367685

Clopidogrel Impurity 20

CAS: 52950-18-2

Formula: C₈H₇ClO₃

Molecular weight: 186.6

Ref: ST-EA-CP-C2041

(R)-2-Chloromandelic acid

CAS: 52950-18-2

(R)-2-Chloromandelic acid is an organic compound with the formula CHClCOH. It is a mandelonitrile, which is a benzene ring fused to a nitrile. It has an optimal reaction at acidic pH and in organic solvents and is enantiopure. The cell lysis of Escherichia coli can be achieved by this compound, as seen through the use of acid dehydrogenase. (R)-2-Chloromandelic acid has been shown to inhibit platelet aggregation, making it an antiplatelet agent. This product can be synthesized using methods such as the enantioselective synthesis of clopidogrel or the asymmetric synthesis of D-mandelic acid methyl ester. The isolated yield for (R)-2-Chloromandelic acid is about 45%.

Formula: C₈H₇ClO₃

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 186.59 g/mol

Ref: 3D-FC03642