CAS 53-86-1

Indomethacin

Description:

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, swelling, and inflammation associated with various conditions, such as arthritis and gout. It is classified as an indole acetic acid derivative and exhibits potent anti-inflammatory and analgesic properties. The chemical formula of indomethacin is C19H16ClN and it has a molecular weight of approximately 357.79 g/mol. Indomethacin functions by inhibiting the cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins, mediators of inflammation and pain. The substance is typically administered orally, but it can also be given rectally or intravenously. Indomethacin is known for its potential side effects, which may include gastrointestinal issues, cardiovascular risks, and renal impairment, necessitating careful monitoring during use. Its solubility is moderate in water, but it is more soluble in organic solvents, which influences its formulation in pharmaceutical preparations. Overall, indomethacin remains an important therapeutic agent in managing inflammatory conditions.

Formula: C₁₉H₁₆ClNO₄

InChI: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChI key: InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3

Synonyms:

• 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• Aconip
• Amuno
• Argun
• Artracin
• Artrinovo
• Artrivia
• Bonidin
• Bonidon Gel
• Catlep
• Chibro-Amuno
• Chrono-Indicid
• Chrono-Indocid 75
• Confortid
• Dolcidium
• Dolcidium PL
• Dolovin
• Durametacin
• Elmetacin
• Endol
• Flam
• Globa
• Idomethine
• Imbrilon
• Inacid
• Indacin
• Indo-Phlogont
• Indo-Rectolmin
• Indo-Tablinen
• IndoRich
• Indocid
• Indocid (pharmaceutical)
• Indocin
• Indocine
• Indocollyre
• Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
• Indomecol
• Indomed
• Indomee
• Indometacin
• Indometacina
• Indometacine
• Indomethacin Crystalline
• Indomethacin Methanol Solution
• Indomethacin Powder
• Indomethacin Usp
• Indomethacine
• Indomethine
• Indomod
• Indonol
• Indoptic
• Indoptol
• Indorektal
• Indoxen
• Indren
• Inflazon
• Infrocin
• Innamit
• Inteban
• Inteban SP
• Lausit
• Metacen
• Metartril
• Methazine
• Metindol
• Mezolin
• Microcid
• Mikametan
• Mobilan
• N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• Nsc 77541
• Reumacide
• Rheumacin LA
• Sadoreum
• Tannex
• Vital Vitacid
• Vonum
• [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate

Indomethacin

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 357.79

Ref: 3B-I0655

Indomethacin, 98%

CAS: 53-86-1

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also p

Formula: C₁₉H₁₆ClNO₄

Purity: 98%

Color and Shape: White to pale cream, Powder

Molecular weight: 357.79

Ref: 02-A19910

Indomethacin, 99+%

CAS: 53-86-1

Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.

Formula: C₁₉H₁₆ClNO₄

Purity: 99+%

Molecular weight: 357.8

Ref: 02-J63255

Indometacin

CAS: 53-86-1

Color and Shape: Neat

Ref: 61-FOR0584.00

Indometacin 1.0 mg/ml in Acetonitrile

CAS: 53-86-1

Color and Shape: Single Solution

Ref: 61-AMP0584.00-11

INDOMETACIN IMPURITY MIXTURE CRS

CAS: 53-86-1

INDOMETACIN IMPURITY MIXTURE CRS

Formula: C₁₇H₁₉N₃

Molecular weight: 265.3529

Ref: 41-Y0001640

INDOMETACIN CRS

CAS: 53-86-1

INDOMETACIN CRS

Formula: C₁₇H₁₉N₃

Color and Shape: Crystalline Powder. White. Yellow. Powder.

Molecular weight: 265.3529

Ref: 41-I0200000

Indomethacin

CAS: 53-86-1

Analgesics, antipyretics and non-hormonal anti-inflammatory agents

Formula: C₁₉H₁₆ClNO₄

Color and Shape: White Yellow Powder

Molecular weight: 357.79

Ref: 45-1341001

Indomethacin

CAS: 53-86-1

Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.

Formula: C₁₉H₁₆ClNO₄

Purity: 99.27% - 99.76%

Color and Shape: Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)

Molecular weight: 357.79

Ref: TM-T0458

Indomethacin

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Color and Shape: White To Off-White Solid

Molecular weight: 357.79

Ref: 4Z-I-121

Indomethacin

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white or pale pink powder

Molecular weight: 357.80

Ref: 7W-GA3090

Indomethacin

CAS: 53-86-1

Indomethacin

Purity: ≥98%

Molecular weight: 357.79g/mol

Ref: 54-BUP19211

Indomethacin, BP grade

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Purity: (Titration) 98.5 - 100.5 % (dried basis)

Color and Shape: White to yellow powder or crystals

Molecular weight: 357.80

Ref: 7W-GP6163

Indomethacin (Indometacin) EP Impurity D

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Color and Shape: White To Off-White Solid

Molecular weight: 357.79

Ref: 4Z-I-1212

Indometacin

Controlled Product

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Color and Shape: Neat

Molecular weight: 357.79

Ref: 86-MM0584.00

Indomethacine

Controlled Product

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Color and Shape: Neat

Molecular weight: 357.79

Ref: 04-C14325000

Indometacin RS

CAS: 53-86-1

Color and Shape: White To Pale Reddish Yellow Solid Crystals To Powder

Ref: 2K-1019000021

Indomethacin

Controlled Product

CAS: 53-86-1

Impurity Acemetacin EP Impurity B
Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)

Formula: C₁₉H₁₆ClNO₄

Color and Shape: Beige

Molecular weight: 357.79

Ref: TR-I641000

Acemetacin EP Impurity B

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Molecular weight: 357.8

Ref: ST-EA-CP-A42002

Indomethacin

CAS: 53-86-1

Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.

Formula: C₁₉H₁₆ClNO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 357.79 g/mol

Ref: 3D-FI24585