CAS 53-86-1
:Indomethacin
Description:
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, swelling, and inflammation associated with various conditions, such as arthritis and gout. It is classified as an indole acetic acid derivative and exhibits potent anti-inflammatory and analgesic properties. The chemical formula of indomethacin is C19H16ClN and it has a molecular weight of approximately 357.79 g/mol. Indomethacin functions by inhibiting the cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins, mediators of inflammation and pain. The substance is typically administered orally, but it can also be given rectally or intravenously. Indomethacin is known for its potential side effects, which may include gastrointestinal issues, cardiovascular risks, and renal impairment, necessitating careful monitoring during use. Its solubility is moderate in water, but it is more soluble in organic solvents, which influences its formulation in pharmaceutical preparations. Overall, indomethacin remains an important therapeutic agent in managing inflammatory conditions.
Formula:C19H16ClNO4
InChI:InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key:InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Synonyms:- 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
- Aconip
- Amuno
- Argun
- Artracin
- Artrinovo
- Artrivia
- Bonidin
- Bonidon Gel
- Catlep
- Chibro-Amuno
- Chrono-Indicid
- Chrono-Indocid 75
- Confortid
- Dolcidium
- Dolcidium PL
- Dolovin
- Durametacin
- Elmetacin
- Endol
- Flam
- Globa
- Idomethine
- Imbrilon
- Inacid
- Indacin
- Indo-Phlogont
- Indo-Rectolmin
- Indo-Tablinen
- IndoRich
- Indocid
- Indocid (pharmaceutical)
- Indocin
- Indocine
- Indocollyre
- Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
- Indomecol
- Indomed
- Indomee
- Indometacin
- Indometacina
- Indometacine
- Indomethacin Crystalline
- Indomethacin Methanol Solution
- Indomethacin Powder
- Indomethacin Usp
- Indomethacine
- Indomethine
- Indomod
- Indonol
- Indoptic
- Indoptol
- Indorektal
- Indoxen
- Indren
- Inflazon
- Infrocin
- Innamit
- Inteban
- Inteban SP
- Lausit
- Metacen
- Metartril
- Methazine
- Metindol
- Mezolin
- Microcid
- Mikametan
- Mobilan
- N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
- Nsc 77541
- Reumacide
- Rheumacin LA
- Sadoreum
- Tannex
- Vital Vitacid
- Vonum
- [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate
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Indomethacin
CAS:Formula:C19H16ClNO4Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:357.79Indomethacin, 98%
CAS:It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also pFormula:C19H16ClNO4Purity:98%Color and Shape:White to pale cream, PowderMolecular weight:357.79Indomethacin, 99+%
CAS:Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.Formula:C19H16ClNO4Purity:99+%Molecular weight:357.8INDOMETACIN IMPURITY MIXTURE CRS
CAS:INDOMETACIN IMPURITY MIXTURE CRSFormula:C17H19N3Molecular weight:265.3529INDOMETACIN CRS
CAS:INDOMETACIN CRSFormula:C17H19N3Color and Shape:Crystalline Powder. White. Yellow. Powder.Molecular weight:265.3529Indomethacin
CAS:Analgesics, antipyretics and non-hormonal anti-inflammatory agentsFormula:C19H16ClNO4Color and Shape:White Yellow PowderMolecular weight:357.07679Indomethacin
CAS:Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.Formula:C19H16ClNO4Purity:99.27% - 99.76%Color and Shape:Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)Molecular weight:357.79Indomethacin, BP grade
CAS:Formula:C19H16ClNO4Purity:(Titration) 98.5 - 100.5 % (dried basis)Color and Shape:White to yellow powder or crystalsMolecular weight:357.80Indomethacin (Indometacin) EP Impurity D
CAS:Formula:C19H16ClNO4Color and Shape:White To Off-White SolidMolecular weight:357.79Indomethacin
CAS:Formula:C19H16ClNO4Purity:≥ 98.0% (dried basis)Color and Shape:White to off-white or pale pink powderMolecular weight:357.80Indomethacin
CAS:Controlled ProductImpurity Acemetacin EP Impurity B
Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)Formula:C19H16ClNO4Color and Shape:BeigeMolecular weight:357.79
