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CAS 53-86-1

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Indomethacin

Description:
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, swelling, and inflammation associated with various conditions, such as arthritis and gout. It is classified as an indole acetic acid derivative and exhibits potent anti-inflammatory and analgesic properties. The chemical formula of indomethacin is C19H16ClN and it has a molecular weight of approximately 357.79 g/mol. Indomethacin functions by inhibiting the cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins, mediators of inflammation and pain. The substance is typically administered orally, but it can also be given rectally or intravenously. Indomethacin is known for its potential side effects, which may include gastrointestinal issues, cardiovascular risks, and renal impairment, necessitating careful monitoring during use. Its solubility is moderate in water, but it is more soluble in organic solvents, which influences its formulation in pharmaceutical preparations. Overall, indomethacin remains an important therapeutic agent in managing inflammatory conditions.
Formula:C19H16ClNO4
InChI:InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key:InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Synonyms:
  • 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
  • 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
  • 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
  • 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
  • See more synonyms
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products per page.Found 22 products.
  • Indomethacin - Bio-X ™
    Biosynth
    + Info

    Indomethacin - Bio-X ™

    CAS:
    Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
    Formula:C19H16ClNO4
    Purity:(%) Min. 95%
    Color and Shape:Powder
    Molecular weight:357.79 g/mol

    Ref: 3D-BI166166

    100mg
    135.00€
  • Indomethacin
    Biosynth
    + Info

    Indomethacin

    CAS:

    Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.

    Formula:C19H16ClNO4
    Purity:Min. 95%
    Color and Shape:White Powder
    Molecular weight:357.79 g/mol

    Ref: 3D-FI24585

    50g
    322.00€
    100g
    499.00€
    250g
    892.00€