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CAS 53-86-1

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Indomethacin

Description:
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, swelling, and inflammation associated with various conditions, such as arthritis and gout. It is classified as an indole acetic acid derivative and exhibits potent anti-inflammatory and analgesic properties. The chemical formula of indomethacin is C19H16ClN and it has a molecular weight of approximately 357.79 g/mol. Indomethacin functions by inhibiting the cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins, mediators of inflammation and pain. The substance is typically administered orally, but it can also be given rectally or intravenously. Indomethacin is known for its potential side effects, which may include gastrointestinal issues, cardiovascular risks, and renal impairment, necessitating careful monitoring during use. Its solubility is moderate in water, but it is more soluble in organic solvents, which influences its formulation in pharmaceutical preparations. Overall, indomethacin remains an important therapeutic agent in managing inflammatory conditions.
Formula:C19H16ClNO4
InChI:InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key:InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Synonyms:
  • 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
  • 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
  • 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
  • 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
  • See more synonyms
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