CAS: 53123-88-9 - Sirolimus

Formula: C₅₁H₇₉NO₁₃

InChI: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChI key: InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N

SMILES: O=C1OC(CC(=O)C(C=C(C)C(O)C(OC)C(=O)C(C)CC(C=CC=CC=C(C)C(OC)CC2OC(O)(C(=O)C(=O)N3CCCCC13)C(C)CC2)C)C)C(C)CC4CCC(O)C(OC)C4

Synonyms:

• (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-
• (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
• (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
• (3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
• 14S-Rapamycin
• 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*S*1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-
• 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.
• 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, [3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-
• 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
• Antibiotic AY 22989
• Ay 22989
• Cypher
• Cypher Bx Velocity
• De 109
• Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-imethoxy-
• Ms-Ro01
• Ms-Ro02
• Ms-Ro03
• Nab rapamycin
• Nsc 226080
• PNP-sirolimus
• Perceiva
• RPM
• Rapa
• Rapammune
• Rapamune
• Rapamycin
• Rapamysin
• Siia 9268A
• Supralimus
• Svp-R
• Wy 090217
• [3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

Rapamycin

CAS: 53123-88-9

• Formula: C₅₁H₇₉NO₁₃
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 914.19

Rapamycin, 98+%

CAS: 53123-88-9

Blocks cytokine-mediated signal transduction pathwaysRapamycin is used to inhibit tumor growth by halting tumor cell …

• Formula: C₅₁H₇₉NO₁₃
• Purity: 98+%
• Color and Shape: White to cream to yellow, Powder or crystals or crystalline powder
• Molecular weight: 914.19

Rapamycin

CAS: 53123-88-9

M02444 - Rapamycin

• Formula: C₅₁H₇₉NO₁₃
• Purity: 98%
• Color and Shape: Solid, Crystalline Powder or Granules or Powder
• Molecular weight: 914.187

Sirolimus

CAS: 53123-88-9

Antibiotics nesoi

• Formula: C₅₁H₇₉NO₁₃
• Color and Shape: Off-White White Powder
• Molecular weight: 913.55514

Rapamycin

CAS: 53123-88-9

Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with …

• Formula: C₅₁H₇₉NO₁₃
• Purity: 97.08% - 99.03%
• Color and Shape: Yellow Solid
• Molecular weight: 914.17

(9S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{(2R)-1-[(3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

CAS: 53123-88-9

• Formula: C₅₁H₇₉NO₁₃
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 914.1719

Rapamycin from Streptomyces hygroscopicus

CAS: 53123-88-9

• Formula: C₅₁H₇₉NO₁₃
• Purity: By hplc: 99.14% (Typical Value in Batch COA)
• Color and Shape: white powder
• Molecular weight: 914.17g/mol

Rapamycin (Sirolimus)

CAS: 53123-88-9

• Formula: C₅₁H₇₉NO₁₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 914.19

Rapamycin

CAS: 53123-88-9

• Formula: C₅₁H₇₉NO₁₃
• Purity: 98.0 - 102.0 % (anhydrous basis)
• Color and Shape: White to yellow crystalline powder
• Molecular weight: 914.17

Sirolimus

CAS: 53123-88-9

• Color and Shape: White Solid

Rapamycin

CAS: 53123-88-9

• Formula: C₅₁H₇₉NO₁₃
• Purity: 95%~99%
• Molecular weight: 914.187

Rapamycin (>85%)

CAS: 53123-88-9

Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word …

• Formula: C₅₁H₇₉NO₁₃
• Purity: >85%
• Color and Shape: Neat
• Molecular weight: 914.17

Rapamycin

CAS: 53123-88-9

Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It …

• Formula: C₅₁H₇₉NO₁₃
• Purity: Min. 95 Area-%
• Color and Shape: White Powder
• Molecular weight: 914.17 g/mol

Rapamycin - Bio-X ™

CAS: 53123-88-9

Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It …

• Formula: C₅₁H₇₉NO₁₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 914.17 g/mol

Rapamycin-13C,d3 (contains d0) - Technical Grade

CAS: 53123-88-9

Binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of …

• Formula: C₅₀CH₇₆D₃NO₁₃
• Purity: Min. 95%
• Molecular weight: 918.18 g/mol

Rapamycin-13C,d3 (contains d0) Technical Grade

CAS: 53123-88-9

Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the …

• Formula: C₅₀CH₇₆D₃NO₁₃
• Color and Shape: Neat
• Molecular weight: 918.18

Sirolimus

CAS: 53123-88-9

• Formula: C₅₁H₇₉NO₁₃
• Color and Shape: Neat
• Molecular weight: 914.17