CAS 53164-05-9: Acemetacin

Description: Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is a derivative of indomethacin and is characterized by its ability to inhibit cyclooxygenase enzymes, which play a crucial role in the synthesis of prostaglandins involved in inflammation and pain signaling. Acemetacin is typically administered in oral form and is known for its relatively favorable gastrointestinal tolerance compared to other NSAIDs. The substance exhibits a moderate to high solubility in organic solvents, while its solubility in water is limited. Its pharmacokinetics involve rapid absorption and metabolism, leading to the formation of its active metabolite, indomethacin. Acemetacin is often prescribed for conditions such as arthritis, musculoskeletal disorders, and postoperative pain. As with other NSAIDs, it may pose risks of cardiovascular and gastrointestinal side effects, necessitating careful consideration of patient history and concurrent medications. Overall, acemetacin serves as an effective option in the management of pain and inflammation.

Formula: C₂₁H₁₈ClNO₆

InChI: InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)

InChI key: InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N

SMILES: O=C(O)COC(=O)CC=1C=2C=C(OC)C=CC2N(C(=O)C3=CC=C(Cl)C=C3)C1C

Synonyms:

• ((1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure [German]
• ({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid ester with glycolic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester
• 2-(2-(1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• 2-[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
• 2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]acetic acid
• Acemet
• Acemetacin [INN:BAN:JAN]
• Acemetacina
• Acemetacina [INN-Spanish]
• Acemetacine
• Acemetacine [INN-French]
• Acemetacinum
• Acemetacinum [INN-Latin]
• Acemethacin
• Acemethazine
• Acemix
• Aximeixin
• Bay f 4975
• Brn 0501672
• Emflex
• K 708
• Rantudil
• Rheumibis
• Rheutrop
• Solart
• Tv 1322
• Tvx 1322
• Tvx 3322
• Unii-5V141Xk28X
• Acemetacin
• 5-22-05-00241 (Beilstein Handbook Reference)
• Acemetacin

Acemetacin

CAS: 53164-05-9

• Formula: C₂₁H₁₈ClNO₆
• Purity: >98.0%(GC)(T)
• Color and Shape: Light yellow to Yellow to Green powder to crystal
• Molecular weight: 415.83

Acemetacin

CAS: 53164-05-9

A potent inhibitor of COX-2 found to have anti-tumor activity in the colon This Thermo …

• Formula: C₂₁H₁₈ClNO₆
• Molecular weight: 415.83

Acemetacin CRS

CAS: 53164-05-9

• Formula: C₂₁H₁₈ClNO₆
• Color and Shape: Yellow. Powder.
• Molecular weight: 415.8237

Acemetacin impurity mixture CRS

CAS: 53164-05-9

• Formula: C₂₁H₁₈ClNO₆
• Molecular weight: 415.8237

Acemetacin

CAS: 53164-05-9

Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin.

• Formula: C₂₁H₁₈ClNO₆
• Purity: 99.26%
• Color and Shape: Light Yellow Solid
• Molecular weight: 415.82

Acemetacin

CAS: 53164-05-9

• Formula: C₂₁H₁₈ClNO₆
• Color and Shape: Pale Yellow Solid
• Molecular weight: 415.83

Acemetacin

CAS: 53164-05-9

• Formula: C₂₁H₁₈ClNO₆
• Molecular weight: 415.83

Acemetacin

CAS: 53164-05-9

• Purity: 99.26%
• Molecular weight: 415.82g/mol

Acemetacin

CAS: 53164-05-9

• Formula: C₂₁H₁₈ClNO₆
• Color and Shape: Neat
• Molecular weight: 415.82

Acemetacin

CAS: 53164-05-9

• Formula: C₂₁H₁₈ClNO₆
• Color and Shape: Neat
• Molecular weight: 415.82

Acemetacin-d4

CAS: 53164-05-9

• Formula: C₂₁H₁₄ClNO₆D₄
• Molecular weight: 419.86

Acemetacin

CAS: 53164-05-9

Applications Acemetacin is a non-steroidal anti-inflammatory agent and used to treat rheumatic disease and other …

• Formula: C₂₁H₁₈ClNO₆
• Color and Shape: Yellow
• Molecular weight: 415.82

Acemetacin

CAS: 53164-05-9

Non-steroidal anti-inflammatory drug

• Formula: C₂₁H₁₈ClNO₆
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 415.82 g/mol