CAS 53164-05-9

Acemetacin

Description:

Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is a derivative of indomethacin and is characterized by its ability to inhibit cyclooxygenase enzymes, which play a crucial role in the synthesis of prostaglandins involved in inflammation and pain signaling. Acemetacin is typically administered in oral form and is known for its relatively favorable gastrointestinal tolerance compared to other NSAIDs. The substance exhibits a moderate to high solubility in organic solvents, while its solubility in water is limited. Its pharmacokinetics involve rapid absorption and metabolism, leading to the formation of its active metabolite, indomethacin. Acemetacin is often prescribed for conditions such as arthritis, musculoskeletal disorders, and postoperative pain. As with other NSAIDs, it may pose risks of cardiovascular and gastrointestinal side effects, necessitating careful consideration of patient history and concurrent medications. Overall, acemetacin serves as an effective option in the management of pain and inflammation.

Formula: C₂₁H₁₈ClNO₆

InChI: InChI=1/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)

InChI key: InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(OCC(O)=O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3

Synonyms:

• ((1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure [German]
• ({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid ester with glycolic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester
• 2-(2-(1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• 2-[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
• 2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]acetic acid
• Acemet
• Acemetacin [INN:BAN:JAN]
• Acemetacina
• Acemetacina [INN-Spanish]
• Acemetacine
• Acemetacine [INN-French]
• Acemetacinum
• Acemetacinum [INN-Latin]
• Acemethacin
• Acemethazine
• Acemix
• Aximeixin
• Bay f 4975
• Brn 0501672
• Emflex
• K 708
• Rantudil
• Rheumibis
• Rheutrop
• Solart
• Tv 1322
• Tvx 1322
• Tvx 3322
• Unii-5V141Xk28X
• Acemetacin
• 5-22-05-00241 (Beilstein Handbook Reference)
• Acemetacin
• 2-(2-(1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)aceticacid
• [1-(4-CHLORO-BENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-ACETIC ACID CARBOXYMETHYL ESTER
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacidcarboxymethyl
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacicarboxymethyl
• AURORA KA-6229
• ((1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)aceticacid
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic aci carboxymethyl ((1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid (1-(p-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic acid carboxymethyl 2-(2-(1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid acemetacin acemetacinum acemix

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Purity: >98.0%(GC)(T)

Color and Shape: Light yellow to Yellow to Green powder to crystal

Molecular weight: 415.83

Ref: 3B-A2452

Acemetacin

CAS: 53164-05-9

A potent inhibitor of COX-2 found to have anti-tumor activity in the colon

Formula: C₂₁H₁₈ClNO₆

Molecular weight: 415.83

Ref: 02-J63583

ACEMETACIN CRS

CAS: 53164-05-9

ACEMETACIN CRS

Formula: C₂₁H₁₈ClNO₆

Color and Shape: Yellow. Powder.

Molecular weight: 415.8237

Ref: 41-Y0000810

ACEMETACIN IMPURITY MIXTURE CRS

CAS: 53164-05-9

ACEMETACIN IMPURITY MIXTURE CRS

Formula: C₂₁H₁₈ClNO₆

Molecular weight: 415.8237

Ref: 41-Y0000842

Acemetacin

CAS: 53164-05-9

Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin.

Formula: C₂₁H₁₈ClNO₆

Purity: 99.26%

Color and Shape: Light Yellow Solid

Molecular weight: 415.82

Ref: TM-T1467

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Molecular weight: 415.83

Ref: 7W-GP9625

Acemetacin

CAS: 53164-05-9

Acemetacin

Purity: ≥98%

Molecular weight: 415.82g/mol

Ref: 54-BUP19931

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Color and Shape: Pale Yellow Solid

Molecular weight: 415.83

Ref: 4Z-A-442

Acemetacin

CAS: 53164-05-9

Acemetacin

Purity: ≥98%

Molecular weight: 415.82g/mol

Ref: 54-BUP17595

Acemetacin

Controlled Product

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Color and Shape: Neat

Molecular weight: 415.82

Ref: 86-MM1728.00

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Color and Shape: Neat

Molecular weight: 415.82

Ref: 04-C10007000

Acemetacin-d4

CAS: 53164-05-9

Formula: C₂₁H₁₄ClNO₆D₄

Molecular weight: 419.86

Ref: 4Z-A-443

Acemetacin

Controlled Product

CAS: 53164-05-9

Applications Acemetacin is a non-steroidal anti-inflammatory agent and used to treat rheumatic disease and other musculoskeletal disorders (1,2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Jacobi, H. and Dell, H. D.: Arzneimittelforschung 30, 1398 (1980) (2) Moore, R. A., et al.: Cochrane Database Syst Rev. 8,CD007589 (2009)

Formula: C₂₁H₁₈ClNO₆

Color and Shape: Yellow

Molecular weight: 415.82

Ref: TR-A130700

Acemetacin

CAS: 53164-05-9

Non-steroidal anti-inflammatory drug

Formula: C₂₁H₁₈ClNO₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 415.82 g/mol

Ref: 3D-FA16912

Acemetacin

CAS: 53164-05-9

Color and Shape: Neat

Ref: 61-FOR1728.00