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CAS 53164-05-9

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Acemetacin

Description:
Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is a derivative of indomethacin and is characterized by its ability to inhibit cyclooxygenase enzymes, which play a crucial role in the synthesis of prostaglandins involved in inflammation and pain signaling. Acemetacin is typically administered in oral form and is known for its relatively favorable gastrointestinal tolerance compared to other NSAIDs. The substance exhibits a moderate to high solubility in organic solvents, while its solubility in water is limited. Its pharmacokinetics involve rapid absorption and metabolism, leading to the formation of its active metabolite, indomethacin. Acemetacin is often prescribed for conditions such as arthritis, musculoskeletal disorders, and postoperative pain. As with other NSAIDs, it may pose risks of cardiovascular and gastrointestinal side effects, necessitating careful consideration of patient history and concurrent medications. Overall, acemetacin serves as an effective option in the management of pain and inflammation.
Formula:C21H18ClNO6
InChI:InChI=1/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)
InChI key:InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(OCC(O)=O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Synonyms:
  • ((1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
  • (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure
  • (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure [German]
  • ({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid ester with glycolic acid
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester
  • 2-(2-(1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
  • 2-[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
  • See more synonyms
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