CAS 53910-25-1

Pentostatin

Description:

Pentostatin, with the CAS number 53910-25-1, is a purine nucleoside analog that exhibits potent antineoplastic properties. It is primarily used in the treatment of certain types of leukemia and lymphoma, particularly hairy cell leukemia. Pentostatin functions by inhibiting the enzyme adenosine deaminase, which is crucial for the metabolism of purines. This inhibition leads to the accumulation of toxic metabolites in lymphocytes, ultimately inducing apoptosis in malignant cells. The compound is typically administered intravenously and has a specific dosage regimen due to its potential side effects, which can include myelosuppression, gastrointestinal disturbances, and immunosuppression. Pentostatin is characterized by its molecular formula, which reflects its structure as a modified purine, and it is known for its relatively low solubility in water. Its therapeutic efficacy is often evaluated in clinical settings, and it is classified as an antimetabolite. As with any chemotherapeutic agent, careful monitoring of patients is essential to manage adverse effects and assess treatment response.

Formula: C₁₁H₁₆N₄O₄

InChI: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChI key: InChIKey=FPVKHBSQESCIEP-JQCXWYLXSA-N

SMILES: O[C@H]1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC=NC1

Synonyms:

• (8R)-3-(2-Deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
• (8R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
• (8R)-3-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-4H-imidazo[4,5-f][1,3]diazepin-8-ol
• (R)-3-(2-Deoxy-Beta-D-Erythro-Pento-Furanosyl)-3,6,7,8-Tetrahydroimidazo[4,5-D
• (R)-3-(2-Deoxy-Beta-D-Pentofuranosyl)-3,6,7,8-Tetrahydroimidazo(4,5-D)(1,3)D
• (R)-Deoxycoformycin
• (R)-Rahydro
• 2'-Dcf
• 2'-Dexoycoformycin
• 2’-Deoxycoformycin
• 2’Dcf
• Ci-825
• Cl 67310465
• Cl 825
• Co-V
• Co-Vidarabine
• Coforin
• Deaminase inhibitor
• Deoxycoformycin
• Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
• Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
• Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
• Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
• Nipent
• Nsc 218321
• Nsc 247520
• Pd-Adi
• Vira A deaminase inhibitor

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

CAS: 53910-25-1

Formula: C₁₁H₁₆N₄O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 268.2691

Ref: IN-DA0038O6

Pentostatin

CAS: 53910-25-1

Pentostatin

Purity: ≥98%

Molecular weight: 268.27g/mol

Ref: 54-BUP05961

Pentostatin

CAS: 53910-25-1

Formula: C₁₁H₁₆N₄O₄

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White to off-white powder

Molecular weight: 268.27

Ref: 7W-GP7108

Pentostatin

CAS: 53910-25-1

Pentostatin

Purity: 99%

Molecular weight: 268.27g/mol

Ref: 54-BISN0008

Pentostatin

CAS: 53910-25-1

Pentostatin (CI-825) is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).

Formula: C₁₁H₁₆N₄O₄

Purity: 99.57% - 99.89%

Color and Shape: White Crystals

Molecular weight: 268.27

Ref: TM-T4006

Pentostatin

Controlled Product

CAS: 53910-25-1

Applications An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rogler-Brown, T. et al.: Biochem. Pharmacol., 28, 201 (1979); Johnston, J.B. et al.: J. Natl. Canvcer Inst., 80, 765 (1988); Fortune, A.F. et al.: Leuk. and Lymph., 51, 839 (2010); Robak, T. et al.: Drugs, 69, 2415 (2009);

Formula: C₁₁H₁₆N₄O₄

Color and Shape: White To Off-White

Molecular weight: 268.27

Ref: TR-P227350

2'-Deoxycoformycin

CAS: 53910-25-1

2'-Deoxycoformycin is a potent adenosine deaminase inhibitor, which is derived from the fermentation of Streptomyces antibioticus, a species of actinomycete bacteria. This compound acts by specifically inhibiting the enzyme adenosine deaminase, leading to an accumulation of toxic deoxyadenosine triphosphate in lymphocytes. This buildup hinders DNA synthesis, effectively suppressing the proliferation of lymphoid cells.

Formula: C₁₁H₁₆N₄O₄

Purity: Min. 95%

Molecular weight: 268.27 g/mol

Ref: 3D-AD03945