CAS 5399-87-1

6-Chloropurine riboside

Description:

6-Chloropurine riboside is a nucleoside analog characterized by the presence of a purine base, specifically chloropurine, linked to a ribose sugar. This compound features a chlorine atom at the 6-position of the purine ring, which influences its biological activity and interaction with nucleic acid synthesis. It is typically used in research and pharmaceutical applications, particularly in the study of antiviral and anticancer properties due to its ability to interfere with nucleic acid metabolism. The riboside structure allows it to be incorporated into RNA, potentially disrupting normal cellular processes. 6-Chloropurine riboside is soluble in water and exhibits moderate stability under physiological conditions, although it may be subject to enzymatic degradation. Its mechanism of action often involves the inhibition of enzymes involved in nucleotide synthesis, making it a valuable tool in the development of therapeutic agents targeting viral infections and malignancies. Safety and handling precautions should be observed, as with many chemical substances, due to potential toxicity.

Formula: C₁₀H₁₁ClN₄O₄

InChI: InChI=1S/C10H11ClN4O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2/t4-,6-,7-,10-/m1/s1

InChI key: InChIKey=XHRJGHCQQPETRH-KQYNXXCUSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(Cl)N=CN3)O[C@H](CO)[C@H]1O

Synonyms:

• 6-Chloro-6-deaminoadenosine
• 6-Chloro-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-9H-purine
• 6-Chloro-9-β-<span class="text-smallcaps">D</span>-ribofuranosylpurine
• 6-Chloronebularine
• 6-Chloropurine 9-β-<span class="text-smallcaps">D</span>-ribofuranoside
• 6-Chloropurine nucleoside
• 6-Chloropurine ribose
• 6-Chloropurine-9-¤-D-ribofuranoside
• 6-Chloropurine-<span class="text-smallcaps">D</span>-riboside
• 6-Chloropurinosine
• 6-chloro-9-(beta-D-ribofuranosyl)-9H-purine
• 6-chloro-9-alpha-L-lyxofuranosyl-9H-purine
• 6-chloro-9-pentofuranosyl-9H-purine
• 9-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-6-chloropurine
• 9H-Purine, 6-chloro-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• NSC 4910
• 6-Chloropurine riboside
• 6-Chloro-9-β-D-ribofuranosyl-9H-purine
• 9H-Purine, 6-chloro-9-β-D-ribofuranosyl-

6-Chloropurine riboside, 98%

CAS: 5399-87-1

6-Chloropurine riboside is used to study the kinetics and substrate specificity of adenosine deaminase. 6-Chloropurine riboside is benzoylated to facilitate synthesis of nucleoside derivatives such as 9-(2,3-Di-deoxy-2-fluoro--D-threo-pentofuranosyl)adenine. It , especially after phosphorylation to

Formula: C₁₀H₁₁ClN₄O₄

Purity: 98%

Molecular weight: 286.67

Ref: 02-H59634

6-Chloropurine 9-β-D-ribofuranoside

CAS: 5399-87-1

Formula: C₁₀H₁₁ClN₄O₄

Purity: 96%

Color and Shape: Solid

Molecular weight: 286.6717

Ref: IN-DA0034CT

6-Chloropurine riboside

CAS: 5399-87-1

6-Chloropurine riboside

Purity: ≥95%

Molecular weight: 286.67g/mol

Ref: 54-BUP17599

6-Chloropurine-9-riboside

CAS: 5399-87-1

6-Chloropurine-9-riboside

Formula: C₁₀H₁₁ClN₄O₄

Purity: 98%

Color and Shape: white to off-white powder

Molecular weight: 286.67174g/mol

Ref: 54-OR7990T

6-Chloro-9-(b-D-ribofuranosyl)purine

CAS: 5399-87-1

Formula: C₁₀H₁₁ClN₄O₄

Purity: ≥ 98.0% (dried basis)

Color and Shape: White or pale yellow crystalline powder

Molecular weight: 286.67

Ref: 7W-GN7678

6-Chloropurine Riboside

CAS: 2004-06-0, 5399-87-1

Formula: C₁₀H₁₁ClN₄O₄

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 286.67

Ref: 3B-C2206

6-Chloropurine riboside

CAS: 5399-87-1

6-Chloropurine riboside (6-CPR): purine analog with antitumor, anti-inflammatory, antiviral, antifungal effects, and neuroprotective properties.

Formula: C₁₀H₁₁ClN₄O₄

Purity: 96.84%

Color and Shape: Soild

Molecular weight: 286.6700

Ref: TM-T7826

6-Chloropurine-9-b-D-ribofuranoside

Controlled Product

CAS: 5399-87-1

Applications 6-Chloropurine-9-β-D-ribofuranoside is a substrate for adenosine deaminase.
References Mol. Pharmacol., 2, 574 (1966)

Formula: C₁₀H₁₁ClN₄O₄

Color and Shape: Neat

Molecular weight: 286.67

Ref: TR-C379900

6-Chloro-9-(b-D-ribofuranosyl)purine

CAS: 5399-87-1

6-Chloro-9-(b-D-ribofuranosyl)purine is a purine analog that inhibits the synthesis of DNA, RNA, and protein. It has been shown to have physiological effects in cells, and it has been used as a positive control for enzyme activity studies. 6-Chloro-9-(b-D-ribofuranosyl)purine binds to an enzyme called hydroxymethylbilane synthase (HMBS), which inhibits the production of a molecule called tetrahydrobiopterin (THB). THB is essential for the synthesis of nitric oxide (NO), an important neurotransmitter that regulates neuronal death. 6-Chloro-9-(b-D-ribofuranosyl)purine also has significant cytotoxicity against melanoma cells in vitro.

Formula: C₁₀H₁₁ClN₄O₄

Purity: Min. 96 Area-%

Color and Shape: Powder

Molecular weight: 286.68 g/mol

Ref: 3D-NC06562

6-Chloropurine riboside

CAS: 5399-87-1

Formula: C₁₀H₁₁ClN₄O₄

Purity: 96%

Color and Shape: Solid, White to off-white powder

Molecular weight: 286.67

Ref: 10-F404220