CAS 5451-40-1

2,6-Dichloropurine

Description:

2,6-Dichloropurine is a purine derivative characterized by the presence of two chlorine atoms at the 2 and 6 positions of the purine ring. Its molecular formula is C5H3Cl2N4, and it has a molecular weight that reflects its composition of carbon, hydrogen, chlorine, and nitrogen atoms. This compound typically appears as a white to off-white crystalline solid and is soluble in polar solvents like water and alcohols. 2,6-Dichloropurine is primarily used in biochemical research and has applications in the synthesis of nucleoside analogs, which can be important in the study of nucleic acid metabolism and the development of antiviral and anticancer agents. The presence of chlorine substituents can influence its reactivity and biological activity, making it a compound of interest in medicinal chemistry. As with many halogenated compounds, safety precautions should be taken when handling 2,6-Dichloropurine due to potential toxicity and environmental concerns.

Formula: C₅H₂Cl₂N₄

InChI: InChI=1S/C5H2Cl2N4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)

InChI key: InChIKey=RMFWVOLULURGJI-UHFFFAOYSA-N

SMILES: ClC1=C2C(=NC(Cl)=N1)N=CN2

Synonyms:

• 1H-Purine, 2,6-dichloro-
• 2,6-Dichloro-1H-purine
• 2,6-Dichloro-9H-purin
• 2,6-dichloro-5H-purine
• 2,6-dichloro-7H-purine
• 2,6-dichloro-9H-purine
• 9H-Purine, 2,6-dichloro-
• NSC 18395
• Purine, 2,6-dichloro-
• 2,6-Dichloropurine

2,6-Dichloropurine

CAS: 5451-40-1

Formula: C₅H₂Cl₂N₄

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow to Dark green powder to crystal

Molecular weight: 189.00

Ref: 3B-D2470

2,6-Dichloropurine, 97%

CAS: 5451-40-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₅H₂Cl₂N₄

Purity: 97%

Color and Shape: White to pale yellow or pale pink, Powder

Molecular weight: 189.01

Ref: 02-B21289

2,6-Dichloropurine

CAS: 5451-40-1

Formula: C₅H₂Cl₂N₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 189.0022

Ref: IN-DA00331B

2,6-Dichloropurine

CAS: 5451-40-1

Formula: C₅H₂Cl₂N₄

Molecular weight: 189.01

Ref: 7W-GE4822

2,6-Dichloropurine

CAS: 5451-40-1

Color and Shape: Neat

Ref: 86-MM0061.10

2,6-Dichloro-9H-purine

CAS: 5451-40-1

2,6-Dichloro-9H-purine

Formula: C₅H₂Cl₂N₄

Purity: 98%

Color and Shape: white to off white powder

Molecular weight: 189.00g/mol

Ref: 54-OR11256

2,6-Dichloropurine

CAS: 5451-40-1

2,6-Dichloropurine is a nitrogenous base that inhibits the activity of certain enzymes in the body. It has been shown to inhibit protease activity and nitro reductases, which are enzymes that metabolize nitrosamines. 2,6-Dichloropurine also inhibits the synthesis of epidermal growth factor (EGF) and adenosine A3 receptors in vivo. This drug has potent antitumor activity against various cancer cells and is used for the treatment of HIV infections. 2,6-Dichloropurine can be synthesized from 6-fluoro-3-indoxyl-beta-D-galactopyranoside with an intramolecular hydrogen atom.

Formula: C₅H₂Cl₂N₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 189 g/mol

Ref: 3D-FD06276

2,6-Dichloropurine

CAS: 5451-40-1

Formula: C₅H₂Cl₂N₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 189

Ref: 10-F010789

2,6-Dichloropurine

Controlled Product

CAS: 5451-40-1

Applications 2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.
References Kelley, J.L., et al.: J. Med. Chem., 31, 2001 (1988), Garcia-Echeverria, C., et al.: Med. Res. Rev., 20, 28 (2000);

Formula: C₅H₂Cl₂N₄

Color and Shape: White

Molecular weight: 189.00

Ref: TR-D435760

Clofarabine Impurity A

CAS: 5451-40-1

Formula: C₅H₂Cl₂N₄

Molecular weight: 189

Ref: ST-EA-CP-C83013