CAS 545380-34-5

N~4~-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine

Description:

N~4~-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine is a synthetic organic compound characterized by its quinazoline core structure, which is a bicyclic compound containing a benzene ring fused to a pyrimidine ring. This compound features two amine groups at the 4 and 6 positions of the quinazoline ring, contributing to its potential as a pharmacological agent. The presence of the 4-phenoxyphenyl group attached via an ethyl linker enhances its lipophilicity and may influence its biological activity. Typically, compounds of this nature are investigated for their potential therapeutic applications, particularly in oncology or as kinase inhibitors, due to the structural motifs that can interact with biological targets. The molecular structure suggests that it may exhibit properties such as solubility in organic solvents and moderate stability under standard laboratory conditions. As with many synthetic compounds, the specific characteristics, including solubility, melting point, and reactivity, would need to be determined experimentally.

Formula: C₂₂H₂₀N₄O

InChI: InChI=1/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)

SMILES: c1ccc(cc1)Oc1ccc(cc1)CCN=c1c2cc(ccc2nc[nH]1)N

Synonyms:

• 4,6-quinazolinediamine, N~4~-[2-(4-phenoxyphenyl)ethyl]-
• 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

CAS: 545380-34-5

Formula: C₂₂H₂₀N₄O

Purity: 99%

Color and Shape: Solid

Molecular weight: 356.4204

Ref: IN-DA00D9RL

QNZ

CAS: 545380-34-5

QNZ

Purity: ≥98%

Molecular weight: 356.42g/mol

Ref: 54-BUP04214

QNZ

CAS: 545380-34-5

QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.

Formula: C₂₂H₂₀N₄O

Purity: 99.17% - 99.18%

Color and Shape: White Solid

Molecular weight: 356.42

Ref: TM-T6204

N4-(4-Phenoxyphenethyl)quinazoline-4,6-diamine

CAS: 545380-34-5

Purity: 95.0%

Molecular weight: 356.4289855957031

Ref: 10-F431351

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

Controlled Product

CAS: 545380-34-5

Applications QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
References Tobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Choi, S., et al.: J. Biol. Chem., 281, 12722 (2006)

Formula: C₂₂H₂₀N₄O

Color and Shape: Neat

Molecular weight: 356.42

Ref: TR-A621350

QNZ

CAS: 545380-34-5

Formula: C₂₂H₂₀N₄O

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Green powder to crystal

Molecular weight: 356.43

Ref: 3B-Q0109

EVP4593

CAS: 545380-34-5

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline is a potential anticancer drug that has been shown to inhibit the polymerase chain reaction in human osteosarcoma cells. It also inhibits the signaling pathway of nuclear factor-κB (NF-κB), which is involved in cell death and tumorigenesis. 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline has shown significant cytotoxicity against murine hepatoma cells and bowel disease cells, but not against normal tissue. This drug is also an inhibitor of the drug transporter Pgp. 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline has been shown to be effective in experimental models for cancer, AIDS, and other infectious diseases.

Formula: C₂₂H₂₀N₄O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 356.42 g/mol

Ref: 3D-FA17546