CAS 54573-75-0

Doxercalciferol

Description:

Doxercalciferol, also known as 1α-hydroxyvitamin D2, is a synthetic analog of vitamin D2 that is primarily used in the treatment of secondary hyperparathyroidism, particularly in patients with chronic kidney disease. It functions as a vitamin D receptor agonist, promoting calcium absorption and regulating parathyroid hormone levels. Doxercalciferol is characterized by its ability to enhance intestinal absorption of calcium and phosphate, thereby contributing to bone health and mineral metabolism. The substance is typically administered orally or intravenously, depending on the clinical scenario. Its chemical structure includes a hydroxyl group at the 1α position, which differentiates it from other vitamin D compounds and enhances its potency. Doxercalciferol is generally well-tolerated, but like other vitamin D analogs, it may lead to hypercalcemia if dosed improperly. Monitoring of calcium and phosphate levels is essential during treatment to avoid potential adverse effects. Overall, doxercalciferol plays a significant role in managing mineral and bone disorders associated with renal insufficiency.

Formula: C₂₈H₄₄O₂

InChI: InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1

InChI key: InChIKey=HKXBNHCUPKIYDM-CGMHZMFXSA-N

SMILES: C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](/C=C/[C@@H](C(C)C)C)C)[H])[H]

Synonyms:

• (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
• (1S,3R,5Z,7E,14xi,22E)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol
• (1S,3R,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol
• (2S,4S,5E,7E,17beta)-1-methylidene-17-[(1R,2E)-1,4,5-trimethylhex-2-en-1-yl]-9,10-secoestra-5,7-diene-2,4-diol
• 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
• 1-Alpha-Hydroxyergocalciferol
• 1-Alpha-Hydroxyvitamind2
• 1-Hydroxyergocalciferol
• 1-Hydroxyvitamin D₂
• 1Alpha-Hydroxyergocalciferol
• 1Alpha-Oh-D2
• 1α-Hydroxyergocalciferol
• 1α-Hydroxyvitamin D₂
• 1α-hydroxyergocalciferol (Ercalcidol)
• 7,10(19),22-Tetraene-1,3-Diol,(1-Alpha,3-Beta,5Z,7E,22E)-10-Secoergosta-5
• 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol, (1α,3β,5Z,7E,22E,24R)-
• Doxercalciferol
• Hectorol
• Tsa 840
• Vitamin D2, 1Alpha-Hydroxy-

Doxercalciferol

CAS: 54573-75-0

Other vitamins and their derivatives, nesoi

Formula: C₂₈H₄₄O₂

Color and Shape: White Off-White Powder

Molecular weight: 412.65

Ref: 45-1225601

Doxercalciferol

CAS: 54573-75-0

Formula: C₂₈H₄₄O₂

Molecular weight: 412.65

Ref: 7W-GP1714

Doxercalciferol

CAS: 54573-75-0

Doxercalciferol

Purity: ≥98%

Molecular weight: 412.65g/mol

Ref: 54-BUP04021

Doxercalciferol

CAS: 54573-75-0

Formula: C₂₈H₄₄O₂

Molecular weight: 412.66

Ref: 4Z-D-144001

Doxercalciferol

CAS: 54573-75-0

Formula: C₂₈H₄₄O₂

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 412.66

Ref: 3B-D5526

Doxercalciferol

CAS: 54573-75-0

Doxercalciferol, a synthetic vitamin D2, curbs parathyroid activity for treating secondary hyperparathyroidism and bone disorders.

Formula: C₂₈H₄₄O₂

Purity: 99.03% - 99.69%

Color and Shape: White Crystalline Powder

Molecular weight: 412.65

Ref: TM-T6112

Doxercalciferol

Controlled Product

CAS: 54573-75-0

Stability Light Sensitive
Applications Synthetic vitamin D prohormone. A new active Vitamin D analog which inhibits growth of human neuroblastoma. Antihyperparathyroid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, G., et al.: Clin. Cancer Res., 9(11), 4077 (2003), Albert, D., et al.: Arch. Ophthalmol., 122(9), 1365 (2004), Nagai, J., et al.: Cancer Res., 64, 7910 (2004), Reddy, C., et al.: J. Cell Biochem., 97, 198 (2006), Peng, X., et al.: Carcinogenesis, 28, 1000 (2007),

Formula: C₂₈H₄₄O₂

Color and Shape: Neat

Molecular weight: 412.65

Ref: TR-H995800

β-Doxercalciferol

Controlled Product

CAS: 54573-75-0

Formula: C₂₈H₄₄O₂

Color and Shape: Neat

Molecular weight: 412.65

Ref: TR-D552543

Doxercalciferol

CAS: 54573-75-0

Formula: C₂₈H₄₄O₂

Color and Shape: White To Off-White Solid

Molecular weight: 412.66

Ref: 4Z-V-083