CAS 54573-75-0
:Doxercalciferol
Description:
Doxercalciferol, also known as 1α-hydroxyvitamin D2, is a synthetic analog of vitamin D2 that is primarily used in the treatment of secondary hyperparathyroidism, particularly in patients with chronic kidney disease. It functions as a vitamin D receptor agonist, promoting calcium absorption and regulating parathyroid hormone levels. Doxercalciferol is characterized by its ability to enhance intestinal absorption of calcium and phosphate, thereby contributing to bone health and mineral metabolism. The substance is typically administered orally or intravenously, depending on the clinical scenario. Its chemical structure includes a hydroxyl group at the 1α position, which differentiates it from other vitamin D compounds and enhances its potency. Doxercalciferol is generally well-tolerated, but like other vitamin D analogs, it may lead to hypercalcemia if dosed improperly. Monitoring of calcium and phosphate levels is essential during treatment to avoid potential adverse effects. Overall, doxercalciferol plays a significant role in managing mineral and bone disorders associated with renal insufficiency.
Formula:C28H44O2
InChI:InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChI key:InChIKey=HKXBNHCUPKIYDM-CGMHZMFXSA-N
SMILES:C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](/C=C/[C@@H](C(C)C)C)C)[H])[H]
Synonyms:- (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
- (1S,3R,5Z,7E,14xi,22E)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol
- (1S,3R,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol
- (2S,4S,5E,7E,17beta)-1-methylidene-17-[(1R,2E)-1,4,5-trimethylhex-2-en-1-yl]-9,10-secoestra-5,7-diene-2,4-diol
- 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
- 1-Alpha-Hydroxyergocalciferol
- 1-Alpha-Hydroxyvitamind2
- 1-Hydroxyergocalciferol
- 1-Hydroxyvitamin D<sub>2</sub>
- 1Alpha-Hydroxyergocalciferol
- 1Alpha-Oh-D2
- 1α-Hydroxyergocalciferol
- 1α-Hydroxyvitamin D<sub>2</sub>
- 1α-hydroxyergocalciferol (Ercalcidol)
- 7,10(19),22-Tetraene-1,3-Diol,(1-Alpha,3-Beta,5Z,7E,22E)-10-Secoergosta-5
- 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol, (1α,3β,5Z,7E,22E,24R)-
- Doxercalciferol
- Hectorol
- Tsa 840
- Vitamin D2, 1Alpha-Hydroxy-
- See more synonyms
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Doxercalciferol
CAS:Formula:C28H44O2Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:412.66Doxercalciferol
CAS:Other vitamins and their derivatives, nesoiFormula:C28H44O2Color and Shape:White Off-White PowderMolecular weight:412.33413Doxercalciferol
CAS:DoxercalciferolFormula:C28H44O2Purity:99%Color and Shape:SolidMolecular weight:412.65Doxercalciferol
CAS:Controlled ProductStability Light Sensitive
Applications Synthetic vitamin D prohormone. A new active Vitamin D analog which inhibits growth of human neuroblastoma. Antihyperparathyroid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, G., et al.: Clin. Cancer Res., 9(11), 4077 (2003), Albert, D., et al.: Arch. Ophthalmol., 122(9), 1365 (2004), Nagai, J., et al.: Cancer Res., 64, 7910 (2004), Reddy, C., et al.: J. Cell Biochem., 97, 198 (2006), Peng, X., et al.: Carcinogenesis, 28, 1000 (2007),Formula:C28H44O2Color and Shape:NeatMolecular weight:412.65Doxercalciferol
CAS:Doxercalciferol, a synthetic vitamin D2, curbs parathyroid activity for treating secondary hyperparathyroidism and bone disorders.Formula:C28H44O2Purity:99.03% - 99.24%Color and Shape:SolidMolecular weight:412.65Doxercalciferol
CAS:(1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-Dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diolFormula:C28H44O2Purity:99%Molecular weight:412.65
