CAS 54827-14-4

Ganglioside GM3

Description:

Ganglioside GM3 is a glycosphingolipid that plays a crucial role in cellular recognition and signaling processes. It is primarily found in the membranes of neurons and other cell types, where it contributes to the structural integrity and functionality of the cell membrane. GM3 is characterized by its complex structure, which includes a ceramide backbone linked to a sialic acid-containing oligosaccharide chain. This unique composition allows GM3 to participate in various biological functions, including cell-cell interactions, modulation of receptor activity, and involvement in immune responses. Additionally, GM3 has been studied for its potential implications in neurodegenerative diseases and cancer, as it can influence cell growth and differentiation. Its presence in the nervous system highlights its importance in neurobiology, while its role in cell signaling pathways underscores its significance in various physiological and pathological processes. Overall, GM3 is a vital component of cellular membranes, contributing to both structural and functional aspects of cell biology.

Formula: Unspecified

Synonyms:

• G_Lac1
• G_M3
• GLac1
• GM3
• Ganglioside G_M3
• Ganglioside M3
• Ganglioside M₃
• Gangliosides, GM3
• Hematoside
• Monosialodihexosylganglioside
• Sialosyllactosylceramide

Ganglioside GM3 Mixture (sodium salt)

CAS: 54827-14-4

GM3 ganglioside inhibits tumor growth, angiogenesis, and HUVEC migration by disrupting cell signaling and insulin receptors.

Formula: C₅₉H₁₀₇N₂NaO₂₁

Color and Shape: Solid

Molecular weight: 1203.488

Ref: TM-T35588

Monosialoganglioside GM3 (bovine)

CAS: 54827-14-4

Formula: Unspecified

Purity: >98%

Color and Shape: Solid

Ref: 48-56-1107

GM3-Ganglioside

CAS: 54827-14-4

Formula: C₅₉H₁₀₇N₂O₂₁·Na

Purity: ≥ 98.0%

Color and Shape: White to light-yellow powder

Molecular weight: 1203.5

Ref: 7W-GC6381

GM3-Ganglioside sodium

CAS: 54827-14-4

Ganglioside GM3 (sodium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as: lung, brain and melanomas, where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function and immune disorders (e.g., allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

Formula: C₆₄H₁₁₈N₂O₂₁·xNa

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 1,252 g/mol

Ref: 3D-OG16188

Monosialoganglioside GM3 Sodium Salt

Controlled Product

CAS: 54827-14-4

Applications Monosialoganglioside GM3 can have anti-tumor effects by regulating cell apoptosis, angiogenesis. Monosialoganglioside GM3 can also regulate peripheral insulin receptor signaling and increases in GM3 in adipose tissue of obese humans may contribute to insulin resistance.
References Zhu, Y., et al.: Zhongliu Fangzhi Yanjiu, 42, 450 (2015); Herzer, S., et al.: Diabetes, 64, 3363 (2015); Wentworth, J., et al.: ?Int. J. Obes., 40, 706 (2016)

Formula: C₅₉H₁₀₇N₂NaO₂₁

Color and Shape: Neat

Molecular weight: 1203.47

Ref: TR-M567140

GM3-Ganglioside ammonium

CAS: 54827-14-4

Ganglioside GM3 (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked a2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain and melanomas where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganlioside is implicated in various other diseases involving chronic inflammation, such as, insulin resistance, leptin resistance, T-cell function and immune disorders (e.g. allergic asthma). GM3 ganglioside has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

Formula: C₅₉H₁₁₁N₃O₂₁xNH₄

Purity: Min. 95%

Molecular weight: 1,198.52 g/mol

Ref: 3D-OG175970