CAS 55-18-5
:Diethylnitrosamine
Description:
Diethylnitrosamine (DEN) is an organic compound classified as a nitrosamine, with the chemical formula C4H10N2O. It is a colorless to pale yellow liquid with a characteristic odor. DEN is primarily known for its role as a potent carcinogen, particularly in laboratory studies involving animal models, where it has been linked to the induction of various types of tumors, especially in the liver. The compound is formed through the reaction of nitrites with secondary amines, and it is often used in research to study cancer mechanisms and the effects of chemical carcinogens. Due to its toxicological properties, diethylnitrosamine is handled with caution in laboratory settings, and exposure can occur through inhalation, ingestion, or skin contact. It is important to note that DEN is regulated in many countries due to its potential health risks, and safety protocols must be followed when working with this substance. Additionally, its presence in the environment can arise from certain industrial processes and the degradation of other nitrosamines.
Formula:C4H10N2O
InChI:InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
InChI key:InChIKey=WBNQDOYYEUMPFS-UHFFFAOYSA-N
SMILES:N(CC)(CC)N=O
Synonyms:- DEN
- DEN (mutagen)
- Dena
- Diethylamine, N-nitroso-
- Diethylnitrosamide
- Diethylnitrosamine
- Diethylnitrosoamin
- Diethylnitrosoamine
- Dietilnitrosoamina
- N,N-Diethylnitrosoamine
- N-Ethyl-N-nitrosoethanamine
- N-Nitroso-N,N-diethylamine
- N-Nitrosodiaethylamin
- N-Nitrosodiethylamine
- Ndea
- Nitrosodiethylamine
- Nsc 132
- See more synonyms
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N-Nitroso-diethylamine 100 µg/mL in Methanol
CAS:Controlled ProductFormula:C4H10N2OColor and Shape:Single SolutionMolecular weight:102.14N-Nitrosodiethylamine
CAS:<p>N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine.</p>Formula:C4H10N2OPurity:99.26% - 99.88%Color and Shape:SolidMolecular weight:102.14N-Nitrosodiethylamine (100 ug/mL in Methanol)
CAS:Controlled ProductFormula:C4H10N2OColor and Shape:Single SolutionMolecular weight:102.14N-Nitrosodiethylamine
CAS:Controlled Product<p>Applications N-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens (1) primarily inducing tumors of liver (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Farber, E. et al.: Cancer Res. 1984 Oct;44(10):4217-23.2. el-Demerdash, E. et al.: Anticancer Res. 2002 Mar-Apr;22(2A):977-84.3. Kweon, S. et al.: Life Sci. 2003 Sep 26;73(19):2515-26.<br></p>Formula:C4H10N2OColor and Shape:YellowMolecular weight:102.14N-Nitrosodiethylamine (1 mg/mL in Methanol)
CAS:Formula:C4H10N2OColor and Shape:Single SolutionMolecular weight:102.14N-Nitrosodiethylamine
CAS:<p>N-Nitrosodiethylamine (NDEA) is a genotoxic carcinogen that is formed as an intermediate in the industrial production of nitric acid. It has been shown to be a potent inhibitor of DNA polymerase and topoisomerase II, which are involved in DNA replication and repair. NDEA has been detected in human blood samples and has been shown to induce squamous cell carcinoma in animal models. This chemical can also cause inflammation by binding to toll-like receptor 4, which activates the inflammatory response. The biocompatible polymer used for this product is not known to produce any genotoxic or mutagenic effects.</p>Formula:C4H10N2OPurity:Min. 95%Color and Shape:Colorless Clear LiquidMolecular weight:102.14 g/molHJ 809-2016 Nitrosoamines Mixture 519 1000 µg/mL in Dichloromethane
CAS:Controlled ProductColor and Shape:Mixture
