CAS 55134-13-9

Narasin

Description:

Narasin is a polyether ionophore antibiotic primarily used as a veterinary drug, particularly in poultry and livestock for its growth-promoting properties and to prevent coccidiosis. It is produced by the fermentation of certain strains of Streptomyces species. Narasin functions by disrupting ion transport across cell membranes, particularly affecting sodium and potassium ions, which leads to altered cellular metabolism in susceptible organisms. This compound is characterized by its ability to form complexes with cations, enhancing their transport across lipid membranes. Narasin is typically administered in feed formulations and is known for its effectiveness against various protozoan parasites. However, its use is regulated in many countries due to concerns about antibiotic resistance and potential residues in animal products. Safety assessments have indicated that while it is effective in promoting animal health, careful management of dosages is essential to minimize environmental impact and ensure food safety. As with all veterinary drugs, adherence to withdrawal periods before slaughter is crucial to prevent residues in meat and eggs.

Formula: C₄₃H₇₂O₁₁

InChI: InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1

InChI key: InChIKey=VHKXXVVRRDYCIK-CWCPJSEDSA-N

SMILES: O[C@H]1[C@]2(O[C@@]3(O[C@]([C@H](C([C@H]([C@H]([C@H](C)[C@@]4(O[C@@]([C@H](C(O)=O)CC)([C@@H](C)C[C@@H]4C)[H])[H])O)C)=O)CC)([C@@H](C)C[C@H]3C)[H])C=C1)O[C@@](C)(CC2)[C@@]5(O[C@@H](C)[C@](CC)(O)CC5)[H]

Synonyms:

• (2R)-2-{(2R,3S,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl}-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3,5-dimethyltetrahydro-2H-pyran-2-yl}butanoic acid
• (4S)-4-Methylsalinomycin
• 1,6,8-Trioxadispiro[4.1.5.3]pentadecane, salinomycin deriv.
• 2-(6-{6-[2-(5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl}-3,5-dimethyltetrahydro-2H-pyran-2-yl)butanoic acid
• A 28086A
• Antibiotic A 28086A
• Antibiotic C 7819B
• C 7819B
• Monteban
• Narasin
• Narasin A
• Narasul

Narasin

CAS: 55134-13-9

Antibiotics nesoi

Formula: C₄₃H₇₂O₁₁

Color and Shape: Off-White Powder

Molecular weight: 764.50746

Ref: 45-1457458

Narasin

CAS: 55134-13-9

Formula: C₄₃H₇₂O₁₁

Purity: ≥ 94.0%

Color and Shape: White to off-white solid

Molecular weight: 765.03

Ref: 7W-GA9999

Narasin

CAS: 55134-13-9

Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.

Formula: C₄₃H₇₂O₁₁

Color and Shape: Solid

Molecular weight: 765.03

Ref: TM-T19740

Narasin 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 55134-13-9

Formula: C₄₃H₇₂O₁₁

Color and Shape: Single Solution

Molecular weight: 765.03

Ref: 04-A15494000AL-1000

Narasin 100 µg/mL in Acetonitrile

CAS: 55134-13-9

Formula: C₄₃H₇₂O₁₁

Color and Shape: Single Solution

Molecular weight: 765.03

Ref: 04-A15494000AL-100

Narasin

CAS: 55134-13-9

Formula: C₄₃H₇₂O₁₁

Molecular weight: 765.04

Ref: 4Z-N-182001

Narasin

Controlled Product

CAS: 55134-13-9

Applications Narasin is the main component of a polyether antibiotic complex produced by Streptomyces auriofaciens NRRL 5758 & NRRL 8092. Ionophoric antibiotic which inhibits coccidial infection in poultry and mammals. Coccidiostat; growth stimulant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Berg, D.H., et al.: J. Antibiot., 31, 1 (1978), Ruff, M.D., et al.: Poult. Sci., 59, 2008 (1980),

Formula: C₄₃H₇₂O₁₁

Color and Shape: Off-White

Molecular weight: 765.03

Ref: TR-N378770

Narasin

CAS: 55134-13-9

Narasin is an ionophore antibiotic, which is a fermentation product derived from certain strains of the bacterium *Streptomyces aureofaciens*. It functions by disrupting the ion gradients across cell membranes, specifically facilitating the transport of sodium and potassium ions. This action interferes with the energy metabolism of certain pathogenic microorganisms, rendering them unable to proliferate effectively.

Formula: C₄₃H₇₂O₁₁

Purity: Min. 95%

Molecular weight: 765.03 g/mol

Ref: 3D-AN26161