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CAS 55134-13-9

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Narasin

Description:
Narasin is a polyether ionophore antibiotic primarily used as a veterinary drug, particularly in poultry and livestock for its growth-promoting properties and to prevent coccidiosis. It is produced by the fermentation of certain strains of Streptomyces species. Narasin functions by disrupting ion transport across cell membranes, particularly affecting sodium and potassium ions, which leads to altered cellular metabolism in susceptible organisms. This compound is characterized by its ability to form complexes with cations, enhancing their transport across lipid membranes. Narasin is typically administered in feed formulations and is known for its effectiveness against various protozoan parasites. However, its use is regulated in many countries due to concerns about antibiotic resistance and potential residues in animal products. Safety assessments have indicated that while it is effective in promoting animal health, careful management of dosages is essential to minimize environmental impact and ensure food safety. As with all veterinary drugs, adherence to withdrawal periods before slaughter is crucial to prevent residues in meat and eggs.
Formula:C43H72O11
InChI:InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1
InChI key:InChIKey=VHKXXVVRRDYCIK-CWCPJSEDSA-N
SMILES:O[C@H]1[C@]2(O[C@@]3(O[C@]([C@H](C([C@H]([C@H]([C@H](C)[C@@]4(O[C@@]([C@H](C(O)=O)CC)([C@@H](C)C[C@@H]4C)[H])[H])O)C)=O)CC)([C@@H](C)C[C@H]3C)[H])C=C1)O[C@@](C)(CC2)[C@@]5(O[C@@H](C)[C@](CC)(O)CC5)[H]
Synonyms:
  • (2R)-2-{(2R,3S,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl}-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3,5-dimethyltetrahydro-2H-pyran-2-yl}butanoic acid
  • (4S)-4-Methylsalinomycin
  • 1,6,8-Trioxadispiro[4.1.5.3]pentadecane, salinomycin deriv.
  • 2-(6-{6-[2-(5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl}-3,5-dimethyltetrahydro-2H-pyran-2-yl)butanoic acid
  • A 28086A
  • Antibiotic A 28086A
  • Antibiotic C 7819B
  • C 7819B
  • Monteban
  • Narasin
  • See more synonyms
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