CAS 5534-09-8

Beclomethasone dipropionate

Description:

Beclomethasone dipropionate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in the treatment of respiratory conditions such as asthma and allergic rhinitis. It is characterized by its ability to reduce inflammation and alleviate symptoms associated with these conditions. The substance is typically administered via inhalation or as a nasal spray, allowing for localized action with minimal systemic absorption. Chemically, it is a derivative of beclomethasone, featuring two propionate ester groups that enhance its lipophilicity and potency. Beclomethasone dipropionate exhibits a high affinity for glucocorticoid receptors, leading to the modulation of gene expression involved in inflammatory responses. Its pharmacokinetics indicate a rapid onset of action, although the full therapeutic effects may take several days to manifest. Common side effects may include local irritation or dysphonia, but systemic effects are generally minimized due to its targeted delivery. Overall, beclomethasone dipropionate is an effective agent in managing chronic inflammatory conditions of the airways.

Formula: C₂₈H₃₇ClO₇

InChI: InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChI key: InChIKey=KUVIULQEHSCUHY-XYWKZLDCSA-N

SMILES: C(COC(CC)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]

Synonyms:

• (11Beta,16Beta)-9-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate
• (11β,16β)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
• (9Z,11E,13Z)-octadeca-9,11,13-trienoic acid
• 17,21-Dipropionate De 9-Chloro-11Β-Hydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione
• 17,21-Dipropionato De 9-Cloro-11Β-Hidroxi-16Β-Metilpregna-1,4-Dieno-3,20-Diona
• 9-Chlor-11β-hydroxy-16β-methylpregna-1,4-dien-3,20-dion-17,21-dipropionat
• 9-Chloro-11Β-Hydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione 17,21-Dipropionate
• 9α-Chloro-16β-methylprednisolone 17,21-dipropionate
• Aerobec
• Aldecin
• Aldecin AQ nasal
• Anceron
• Andion
• Beclacin
• Beclate
• Beclazone
• Beclazone 250
• Beclazone 50
• Beclomet
• Beclometasone 17,21-dipropionate
• Beclomethasone 17,21-Dipropionate
• Beclomethasone 17α,21-dipropionate
• Beclomethasone dipropionate
• Becloneb
• Beclotide
• Beclotide 100
• Becloval
• Beclovent
• Beclovent Inhaler
• Becodisks
• Beconase
• Beconase AQ
• Becotide
• Belchlorhinol
• Belcoforte
• Belcomet
• Clenil
• Clenil A
• Entyderma
• Inalone O
• Inalone R
• Korbutone
• Nasobec
• Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 9-chloro-11β,17,21-trihydroxy-16β-methyl-, 17,21-dipropionate
• Propaderm
• Propaderm Forte
• Qvar
• Qvar 50
• Rino-Clenil
• Sanasthmax
• Sanasthmyl
• Sanasthymyl
• Sch 8020W
• Topster
• Vancenase
• Vancenase AQ
• Vanceril
• Vanceril DS
• Ventolair
• Viarex
• Viarox
• orBec

Beclomethasone Dipropionate-d10

Controlled Product

CAS: 5534-09-8

Applications Antiallergic, antiasthmatic(inhalate). Anti-inflammatory(topical).
References Laube, B., et al.: J. Allergy Clin. Immunol., 101, 475 (1998), Harrison, L., et al.: Eur. J. Clin. Pharmacol., 58, 191 (2002) , Maneechotesuwan, K., et al.: J. Allergy Clin. Immunol., 121, 43 (2008).

Formula: C₂₈D₁₀H₂₇ClO₇

Color and Shape: Neat

Molecular weight: 531.10

Ref: TR-B131032

Betamethasone Dipropionate EP Impurity E

CAS: 5534-09-8

Formula: C₂₈H₃₇ClO₇

Molecular weight: 521.05

Ref: ST-EA-CP-B26005

Beclomethasone Dipropionate

Controlled Product

CAS: 5534-09-8

Impurity Betamethasone Dipropionate EP Impurity E
Applications Beclomethasone Dipropionate (Betamethasone Dipropionate EP Impurity E) is an antiallergic, antiasthmatic (inhalate). Anti-inflammatory (topical).
References Laube, B., et al.: J. Allergy Clin. Immunol., 101, 475 (1998), Harrison, L., et al.: Eur. J. Clin. Pharmacol., 58, 191 (2002), Maneechotesuwan, K., et al.: J. Allergy Clin. Immunol., 121, 43 (2008).

Formula: C₂₈H₃₇ClO₇

Color and Shape: White

Molecular weight: 521.04

Ref: TR-B131030

Beclometasone dipropionate

CAS: 5534-09-8

Purity: 96%

Molecular weight: 521.0499877929688

Ref: 10-F787569

Beclomethasone dipropionate

Controlled Product

CAS: 5534-09-8

Beclomethasone dipropionate is a synthetic corticosteroid, which is derived from beclomethasone, a glucocorticoid steroid. Its mode of action involves binding to specific intracellular glucocorticoid receptors. This binding modulates the transcription of glucocorticoid-responsive genes, leading to the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory cytokine production. This reduces airway inflammation, edema, and mucus production, and enhances the responsiveness of beta-adrenergic receptors in the bronchial smooth muscle, facilitating bronchodilation.

Formula: C₂₈H₃₇ClO₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 521.04 g/mol

Ref: 3D-FB18155