CAS 5534-09-8

Beclomethasone dipropionate

Description:

Beclomethasone dipropionate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in the treatment of respiratory conditions such as asthma and allergic rhinitis. It is characterized by its ability to reduce inflammation and alleviate symptoms associated with these conditions. The substance is typically administered via inhalation or as a nasal spray, allowing for localized action with minimal systemic absorption. Chemically, it is a derivative of beclomethasone, featuring two propionate ester groups that enhance its lipophilicity and potency. Beclomethasone dipropionate exhibits a high affinity for glucocorticoid receptors, leading to the modulation of gene expression involved in inflammatory responses. Its pharmacokinetics indicate a rapid onset of action, although the full therapeutic effects may take several days to manifest. Common side effects may include local irritation or dysphonia, but systemic effects are generally minimized due to its targeted delivery. Overall, beclomethasone dipropionate is an effective agent in managing chronic inflammatory conditions of the airways.

Formula:C₂₈H₃₇ClO₇

InChI:InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChI key:InChIKey=KUVIULQEHSCUHY-XYWKZLDCSA-N

SMILES:C(COC(CC)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]

Synonyms:

(11Beta,16Beta)-9-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate
(11β,16β)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
(9Z,11E,13Z)-octadeca-9,11,13-trienoic acid
17,21-Dipropionate De 9-Chloro-11Β-Hydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione
17,21-Dipropionato De 9-Cloro-11Β-Hidroxi-16Β-Metilpregna-1,4-Dieno-3,20-Diona
9-Chlor-11β-hydroxy-16β-methylpregna-1,4-dien-3,20-dion-17,21-dipropionat
9-Chloro-11Β-Hydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione 17,21-Dipropionate
9α-Chloro-16β-methylprednisolone 17,21-dipropionate
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