CAS 557795-19-4

Sunitinib

Description:

Sunitinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain cancers, including renal cell carcinoma and gastrointestinal stromal tumors. Its chemical formula is C22H27N3O2, and it features a complex structure that includes a substituted urea moiety, which is crucial for its biological activity. Sunitinib works by inhibiting multiple receptor tyrosine kinases, which are involved in tumor growth and angiogenesis, thereby disrupting the signaling pathways that promote cancer progression. The substance is typically administered orally and is known for its moderate solubility in water, which can affect its bioavailability. Sunitinib has a half-life that allows for once-daily dosing, making it convenient for patients. Common side effects may include fatigue, nausea, and hypertension, reflecting its impact on both tumor and normal cellular processes. Overall, Sunitinib represents a significant advancement in targeted cancer therapy, showcasing the importance of molecular specificity in pharmacological treatment strategies.

Formula: C₂₂H₂₇FN₄O₂

InChI: InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

InChI key: InChIKey=WINHZLLDWRZWRT-ATVHPVEESA-N

SMILES: C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3

Synonyms:

• Sunitinib
• N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
• 5-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N-(2-diethylaminoethyl)amide
• 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
• (Z)-Sunitinib

Sunitinib

CAS: 557795-19-4

Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM).

Formula: C₂₂H₂₇FN₄O₂

Purity: 98% - 99.67%

Color and Shape: Yellow Solid

Molecular weight: 398.47

Ref: TM-T0374L

Sunitinib

CAS: 557795-19-4

Sunitinib

Purity: ≥98%

Molecular weight: 398.47g/mol

Ref: 54-BUP17388

Sunitinib

CAS: 557795-19-4

Sunitinib

Purity: 98%

Molecular weight: 398.47g/mol

Ref: 54-PC109236

Sunitinib (Mixture of E and Z Isomer)

CAS: 557795-19-4

Formula: C₂₂H₂₇FN₄O₂

Color and Shape: Orange Red Solid

Molecular weight: 398.48

Ref: 4Z-S-414

Sunitinib

Controlled Product

CAS: 557795-19-4

Formula: C₂₂H₂₇FN₄O₂

Color and Shape: Neat

Molecular weight: 398.47

Ref: 86-MM3568.01

Sunitinib Malate

CAS: 341031-54-7, 557795-19-4

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Purity: >98.0%(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 532.57

Ref: 3B-U0095

Sunitinib Impurity 32

CAS: 557795-19-4

Formula: C₁₅H₁₃FN₂O

Color and Shape: Orange Red Solid

Molecular weight: 256.28

Ref: 4Z-S-4146

Sunitinib base - Bio-X ™

CAS: 557795-19-4

Sunitinib is a tyrosine kinase inhibitor drug. It is a drug that is used as a treatment for renal cell carcinoma, gastrointestinal stromal tumor, and other solid tumors. This drug inhibits tyrosine kinases such as VEGFRs, this prevents tumour growth and pathologic angiogenesis.

Formula: C₂₂H₂₇FN₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 398.47 g/mol

Ref: 3D-BD164426

Sunitinib base

CAS: 557795-19-4

Multitargeted tyrosine-kinase inhibitor; anti-angiogenic; anti-tumoral agent

Formula: C₂₂H₂₇FN₄O₂

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 398.47 g/mol

Ref: 3D-FD32120

Sodium (Z)-5-(2-(2-Amino-5-fluorophenyl)-2-carboxylatovinyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

Controlled Product

CAS: 557795-19-4

Formula: C₁₆H₁₃FN₂Na₂O₄

Color and Shape: Neat

Molecular weight: 362.263

Ref: TR-S840600

Sunitinib

CAS: 557795-19-4

Color and Shape: Neat

Ref: 61-FOR3568.01