CAS 5579-84-0

Betahistine dihydrochloride

Description:

Betahistine dihydrochloride is a histamine analog primarily used in the treatment of Ménière's disease and other vestibular disorders. It acts as a selective agonist for histamine H1 receptors and an antagonist for H3 receptors, which helps to improve blood flow in the inner ear and reduce symptoms such as vertigo and tinnitus. The substance is typically administered in oral form and is known for its relatively good bioavailability. Chemically, it is characterized by its dihydrochloride salt form, which enhances its solubility in water. Betahistine dihydrochloride is generally well-tolerated, with common side effects including gastrointestinal disturbances and headaches. Its mechanism of action involves modulation of neurotransmitter release and enhancement of microcirculation in the inner ear, contributing to its therapeutic effects. The compound is classified under the category of antihistamines, although it does not exhibit the sedative properties commonly associated with many other drugs in this class. Overall, Betahistine dihydrochloride is a valuable medication for managing balance disorders related to inner ear dysfunction.

Formula: C₈H₁₄Cl₂N₂

InChI: InChI=1/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H

InChI key: InChIKey=XVDFMHARQUBJRE-UHFFFAOYSA-N

SMILES: C(CNC)C1=CC=CC=N1.Cl

Synonyms:

• 2-Pyridineethanamine, N-methyl-, dihydrochloride
• 2-Pyridineethanamine, N-methyl-, hydrochloride (1:2)
• Betahistine dihydrochloride
• Betahistine hydrochloride
• Betaserc
• N-methyl-2-(pyridin-2-yl)ethanamine dihydrochloride
• Pyridine, 2-[2-(methylamino)ethyl]-, dihydrochloride
• Sinmenier
• Vasomotal
• PT 9
• 2-(2-(METHYLAMINO)ETHYL)PYRIDINE DIHYDROCHLORIDE 99%
• n-methyl-2-pyridineethanamindihydrochloride
• 2-(BETA-METHYLAMINOETHYL)PYRIDINE DIHYDROCHLORIDE
• METHYL[2-(2-PYRIDYL)ETHYL]AMINE DIHYDROCHLORIDE
• Betahistine Hydrochloride CP2000
• BetahistineHCl
• BETAHISTINE DIHYDROCHLORIDE:METHYL(2-[2-PYRIDYL]ETHYL)AMINE
• 2-(2-(METHYLAMINO)ETHYL)PYRIDINE DIHYDROCHLORIDE
• BETAHISTINE DIHYDROCHLORIDE (2-(2-(METHYLAMINO)ETHYL)PYRIDINE DIHYDROCHLORIDE)
• Betahistine 2 hcl
• Serc
• BETA-HISTINE DIHDROCHLORIDE
• N-Methyl-2-pyridin-2-ylethanamine dihydrochloride
• Microser

Betahistine dihydrochloride

CAS: 5579-84-0

Betahistine dihydrochloride

Formula: C₈H₁₂N₂HCl

Purity: 99.5%

Color and Shape: White. To. Off-White

Molecular weight: 172.07673

Ref: 47-824

BETAHISTINE DIHYDROCHLORIDE CRS

CAS: 5579-84-0

BETAHISTINE DIHYDROCHLORIDE CRS

Formula: C₈H₁₄Cl₂N₂

Color and Shape: White. Whitish. Powder.

Molecular weight: 209.1162

Ref: 41-Y0000391

Betahistine Hydrochloride

CAS: 5579-84-0

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₈H₁₂N₂·2HCI

Color and Shape: White Light Yellow Crystalline Powder

Molecular weight: 415.92464

Ref: 45-1065618

2-Pyridineethanamine, N-methyl-, dihydrochloride

CAS: 5579-84-0

Formula: C₈H₁₄Cl₂N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 209.1162

Ref: IN-DA00I9YC

Betahistine-13C-d3 DiHCl

CAS: 5579-84-0, 5638-76-6

Formula: C₇₁₃CH₉D₃N₂·2HCl

Color and Shape: Pale Orange Solid

Molecular weight: 140.21 2*36.46

Ref: 4Z-B-364

Betahistine Dihydrochloride

CAS: 5579-84-0

Betahistine Dihydrochloride

Purity: 98%

Molecular weight: 209.12g/mol

Ref: 54-OR1012385

Betahistine Dihydrochloride, 10mM (in DMSO)

CAS: 5579-84-0

Betahistine Dihydrochloride, 10mM (in DMSO)

Purity: ≥98%

Molecular weight: 209.12g/mol

Ref: 54-BUP18938

Betahistine DiHCl

CAS: 5579-84-0

Formula: C₈H₁₂N₂·2HCl

Color and Shape: Pale Orange Solid

Molecular weight: 136.20 2*36.46

Ref: 4Z-B-368

Betahistine Dihydrochloride

CAS: 5579-84-0

Color and Shape: Neat

Ref: 86-MM0587.00

Betahistine dihydrochloride

CAS: 5579-84-0

Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.

Formula: C₈H₁₄Cl₂N₂

Purity: 99.22% - 99.88%

Color and Shape: White To Light Yellow Crystalline Powder

Molecular weight: 209.12

Ref: TM-T0246

Betahistine Dihydrochloride

CAS: 5579-84-0

Formula: C₈H₁₂N₂(HCl)

Molecular weight: 136.2 : 2(36.46)

Ref: ST-EA-CP-B11007

Betahistine Dihydrochloride

CAS: 5579-84-0

Applications Betahistine is most commonly used to treat the symptoms of Ménière's disease and vertigo. Vasodilator.
References Gilligan, P., et al.: J. Med. Chem., 43, 1641 (2000), Keller, P., et al.: Bioorg. Med. Chem., 8, 1213 (2000), Hauger, R., et al.: Pharmacol. Rev., 55, 21 (2003), Han, X., et al.: Bioorg. Med. Chem. Lett., 15, 3870 (2005),

Formula: C₈H₁₂N₂·2ClH

Color and Shape: Neat

Molecular weight: 209.12

Ref: TR-B324001

Betahistine dihydrochloride

CAS: 5579-84-0

Betahistine dihydrochloride is a medication used to treat Ménière's disease, vertigo, and dizziness. It is an antihistamine that acts on histamine H1 receptors in the vestibular system. Betahistine also has vasodilatory effects, which are mediated by its ability to activate the α-adrenergic receptors in the vascular endothelium. This drug is approved for use as a treatment for Ménière's disease and vertigo, but is not approved for treating dizziness. Betahistine dihydrochloride can be administered either intravascularly or orally. The drug undergoes a phase transition from liquid to solid at low temperatures, so it should be stored at room temperature in sealed ampoules and vials to prevent crystallization. Treatment trials have shown that low-dose betahistine (less than 40 mg) may be as effective as higher doses of betahistine (40-120 mg) in the

Formula: C₈H₁₂N₂·2HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 209.12 g/mol

Ref: 3D-FB138972

N-methyl-N-(2-pyridin-2-ylethyl)amine dihydrochloride

CAS: 5579-84-0

Formula: C₈H₁₄Cl₂N₂

Purity: 95+%

Color and Shape: Solid

Molecular weight: 209.11

Ref: 10-F351346