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CAS 5581-52-2

:

Thiamiprine

Description:
Thiamiprine, with the CAS number 5581-52-2, is a chemical compound primarily recognized for its application in the field of medicine, particularly as an immunosuppressive agent. It is a derivative of thiopurine and is often utilized in the treatment of autoimmune diseases and certain types of cancer. The compound exhibits characteristics typical of thiopurines, including the ability to interfere with nucleic acid synthesis, which is crucial for cell proliferation. Thiamiprine is known for its potential side effects, including myelosuppression, which necessitates careful monitoring of blood cell counts during treatment. Its mechanism of action involves the inhibition of purine metabolism, leading to reduced lymphocyte proliferation. Additionally, the pharmacokinetics of thiamiprine can be influenced by genetic factors, particularly variations in enzymes involved in its metabolism, such as thiopurine methyltransferase (TPMT). This variability underscores the importance of personalized medicine in optimizing therapeutic outcomes while minimizing adverse effects. Overall, thiamiprine is a significant compound in pharmacotherapy, particularly in managing complex immune-mediated conditions.
Formula:C9H8N8O2S
InChI:InChI=1S/C9H8N8O2S/c1-16-3-13-6(17(18)19)8(16)20-7-4-5(12-2-11-4)14-9(10)15-7/h2-3H,1H3,(H3,10,11,12,14,15)
InChI key:InChIKey=YFTWHEBLORWGNI-UHFFFAOYSA-N
SMILES:S(C1=C2C(=NC(N)=N1)N=CN2)C3=C(N(=O)=O)N=CN3C
Synonyms:
  • 1-Methyl-4-nitro-5-(2'-amino-6'-purinyl)mercaptoimidazide
  • 1H-Purin-2-amine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)-thio)-
  • 2-Amino-6-((1-methyl-4-nitroimidazol-5-yl)thio)purine
  • 2-Amino-6-(1-methyl-4-nitro-5-imidazolyl)mercaptopurine
  • 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purin-2-amine
  • 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-5H-purin-2-amine
  • 9H-Purin-2-amine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-
  • Ai3-50289
  • Aminoazathioprin
  • Brn 1164867
  • See more synonyms
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