CAS 5581-52-2
:Thiamiprine
Description:
Thiamiprine, with the CAS number 5581-52-2, is a chemical compound primarily recognized for its application in the field of medicine, particularly as an immunosuppressive agent. It is a derivative of thiopurine and is often utilized in the treatment of autoimmune diseases and certain types of cancer. The compound exhibits characteristics typical of thiopurines, including the ability to interfere with nucleic acid synthesis, which is crucial for cell proliferation. Thiamiprine is known for its potential side effects, including myelosuppression, which necessitates careful monitoring of blood cell counts during treatment. Its mechanism of action involves the inhibition of purine metabolism, leading to reduced lymphocyte proliferation. Additionally, the pharmacokinetics of thiamiprine can be influenced by genetic factors, particularly variations in enzymes involved in its metabolism, such as thiopurine methyltransferase (TPMT). This variability underscores the importance of personalized medicine in optimizing therapeutic outcomes while minimizing adverse effects. Overall, thiamiprine is a significant compound in pharmacotherapy, particularly in managing complex immune-mediated conditions.
Formula:C9H8N8O2S
InChI:InChI=1S/C9H8N8O2S/c1-16-3-13-6(17(18)19)8(16)20-7-4-5(12-2-11-4)14-9(10)15-7/h2-3H,1H3,(H3,10,11,12,14,15)
InChI key:InChIKey=YFTWHEBLORWGNI-UHFFFAOYSA-N
SMILES:S(C1=C2C(=NC(N)=N1)N=CN2)C3=C(N(=O)=O)N=CN3C
Synonyms:- 1-Methyl-4-nitro-5-(2'-amino-6'-purinyl)mercaptoimidazide
- 1H-Purin-2-amine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)-thio)-
- 2-Amino-6-((1-methyl-4-nitroimidazol-5-yl)thio)purine
- 2-Amino-6-(1-methyl-4-nitro-5-imidazolyl)mercaptopurine
- 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purin-2-amine
- 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-5H-purin-2-amine
- 9H-Purin-2-amine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-
- Ai3-50289
- Aminoazathioprin
- Brn 1164867
- Bw 57-323
- Bw 57-323H
- Guaneran
- ITG
- Imidazolylthioguanine
- Nsc 38887
- Purine, 2-amino-6-(1-methyl-4-nitro-5-imidazolylthio)-
- Purine, 2-amino-6-[(1-methyl-4-nitroimidazol-5-yl)thio]-
- Thiamiprin
- Thiamiprine
- Thiamiprine [USAN]
- Tiamiprin
- Tiamiprina
- Tiamiprina [INN-Spanish]
- Tiamiprinum
- Tiamiprinum [INN-Latin]
- See more synonyms
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AZATHIOPRINE IMPURITY G CRS
CAS:AZATHIOPRINE IMPURITY G CRSFormula:C9H8N8O2SColor and Shape:White. Powder.Molecular weight:292.2772Azathioprine Related Compound G
CAS:Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoiFormula:C9H8N8O2SColor and Shape:PowderMolecular weight:292.049096-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purin-2-amine
CAS:6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purin-2-amineFormula:C9H8N8O2SPurity:95%Molecular weight:292.28Azathioprine EP Impurity G (Azathioprine USP Related Compound G, Thiamiprine)
CAS:Formula:C9H8N8O2SColor and Shape:Yellow SolidMolecular weight:292.286-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purin-2-amine
CAS:Formula:C9H8N8O2SPurity:95%Color and Shape:SolidMolecular weight:292.2772Thiamiprine
CAS:Thiamiprine is an anti-cancer compound that inhibits the growth of cancer cells. It binds to the antigen binding molecules and blocks the epidermal growth factor receptor, thereby inhibiting tumor cell proliferation. This drug has been shown to be effective against choroidal neovascularization caused by age-related macular degeneration. Thiamiprine has also been shown to be toxic in animals and humans, with effects on the lung, bowel, skin, and kidneys. The toxicity of this drug can be reduced by administering it with other drugs that protect against its side effects.
Formula:C9H8N8O2SPurity:Min. 97 Area-%Color and Shape:PowderMolecular weight:292.28 g/molThiamiprine
CAS:Thiamiprine is an agent with the activity of antineoplastic.Formula:C9H8N8O2SColor and Shape:SolidMolecular weight:292.28
