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CAS 55985-32-5

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Nicardipine

Description:
Nicardipine is a calcium channel blocker primarily used in the management of hypertension and angina pectoris. It belongs to the dihydropyridine class of medications, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. Nicardipine is characterized by its relatively rapid onset of action and a duration that can vary depending on the formulation. It is typically administered orally or intravenously, with the intravenous form often used in acute settings. The chemical structure of nicardipine includes a dihydropyridine ring, which is essential for its pharmacological activity. Additionally, nicardipine has a favorable side effect profile, though it may cause peripheral edema, headache, or flushing in some patients. As with all medications, it is important to monitor for potential interactions with other drugs and to consider patient-specific factors when prescribing nicardipine.
Formula:C26H29N3O6
InChI:InChI=1/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
InChI key:InChIKey=ZBBHBTPTTSWHBA-UHFFFAOYSA-N
SMILES:C(OCCN(CC1=CC=CC=C1)C)(=O)C=2C(C(C(OC)=O)=C(C)NC2C)C3=CC(N(=O)=O)=CC=C3
Synonyms:
  • (.+-.)-Nicardipine
  • 1,4-Dihidro-2,6-Dimetil-4-(M-Nitrofenil)Piridina-3,5-Dicarboxilato De 2-(Bencilmetilamino)Etilo Y Metilo
  • 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)Pyridine-3,5-Dicarboxylate De 2-(Benzylmethylamino)Ethyle Et De Methyle
  • 2-(Benzylmethylamino)Ethyl Methyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)Pyridine-3,5-Dicarboxylate
  • 2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridin-3,5-dicarboxylat
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester
  • Perpidine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester
  • Nicardipine (base and/or unspecified salts)
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[methyl(benzyl)amino]ethyl]5-methyl ester
  • See more synonyms
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