CAS 56-94-0

Demecarium bromide

Description:

Demecarium bromide is a chemical compound classified as a quaternary ammonium compound and is primarily used as a reversible acetylcholinesterase inhibitor. It is characterized by its ability to enhance cholinergic transmission by preventing the breakdown of acetylcholine, making it useful in the treatment of certain types of glaucoma and other conditions where increased cholinergic activity is beneficial. The compound appears as a white to off-white crystalline powder and is soluble in water, which facilitates its application in aqueous formulations. Demecarium bromide has a relatively low toxicity profile when used appropriately, but it can cause side effects such as muscle twitching or gastrointestinal disturbances if overdosed. Its mechanism of action involves the inhibition of the enzyme acetylcholinesterase, leading to increased levels of acetylcholine at neuromuscular junctions and synapses. Due to its pharmacological properties, it is important to handle demecarium bromide with care, following safety guidelines to mitigate any potential risks associated with its use.

Formula: C₃₂H₅₂N₄O₄·2Br

InChI: InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2

InChI key: InChIKey=YHKBUDZECQDYBR-UHFFFAOYSA-L

SMILES: O(C(N(CCCCCCCCCCN(C(OC1=CC([N+](C)(C)C)=CC=C1)=O)C)C)=O)C2=CC([N+](C)(C)C)=CC=C2.[Br-]

Synonyms:

• (m-Hydroxyphenyl)trimethylammonium bromide decamethylenebis[methylcarbamate]
• 3,3'-{decane-1,10-diylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide
• Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis[methylcarbamate] (2:1)
• Bc 48
• Benzenaminium, 3,3'-[1,10-decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethyl-, bromide (1:2)
• Benzenaminium, 3,3'-[1,10-decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethyl-, dibromide
• Bromure De Demecarium
• Bromuro De Demecario
• Decamethylenebis(m-dimethylaminophenyl-N-methylcarbamate) dimethobromide
• Decamethylenebis[N-methylcarbamic acid m-dimethylaminophenyl ester] bromomethylate
• Demecariumbromid
• Demekarium bromide
• Demekastigmine bromide
• Frumtosnil
• Humorsol
• N,N'-Bis[3-trimethylammoniumphenoxycarbonyl]-N,N'-dimethyldecamethylenediamine dibromide
• N,N-decamethylenebis(N,N,N-trimethyl-3-methylcarbamoyloxyanilinium) dibromide
• Tonilen
• Tosmicil
• Tosmilen
• Tosmilene
• Visumatic

Demecarium Bromide

CAS: 56-94-0

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof, nesoi

Formula: C₃₂H₅₂Br₂N₄O₄

Color and Shape: White Pale Yellow Light Pink Crystalline Powder

Molecular weight: 714.23553

Ref: 45-1169001

N,N,N-trimethyl-3-{[methyl({10-[methyl({[3-(trimethylazaniumyl)phenoxy]carbonyl})amino]decyl})carbamoyl]oxy}anilinium dibromide

CAS: 56-94-0

Formula: C₃₂H₅₂Br₂N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 716.5877

Ref: IN-DA00I9ZV

Demecarium bromide

CAS: 56-94-0

Formula: C₃₂H₅₂N₄O₄·2Br

Molecular weight: 716.595

Ref: 7W-GX7487

Demecarium bromide

CAS: 56-94-0

Demecarium bromide

Purity: ≥98%

Molecular weight: 716.59g/mol

Ref: 54-BUP06290

Demecarium Bromide

Controlled Product

CAS: 56-94-0

Formula: C₃₂H₅₂N₄O₄·2Br

Color and Shape: Neat

Molecular weight: 716.59

Ref: 86-MM3042.00

Demecarium Bromide

Controlled Product

CAS: 56-94-0

Applications Demecarium Bromide is an acetylcholinesterase inhibitor and veterinary medicine used to treat elevated intraocular pressure associated with primary glaucoma.
References Drew, K., et al.: J. Pharma. Pharmacol., 64, 490 (2012); Yuan, J., et al.: Sceince., 333, 724 (2011); Chong, C.R., et al.: Nature. Chem. BIol., 2, 415 (2006);

Formula: C₃₂H₅₂N₄O₄·2Br

Color and Shape: Neat

Molecular weight: 716.59

Ref: TR-D230720

Demecarium bromide

CAS: 56-94-0

Demecarium bromide (BC-48) is a potent cholinesterase inhibitor,and is treatment glaucoma agent.

Formula: C₃₂H₅₂Br₂N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 716.59

Ref: TM-T7213

Demecarium bromide

CAS: 56-94-0

Demecarium bromide is a diagnostic drug that can be used to identify the presence of cancer cells. It reacts with sodium citrate and water vapor to produce a red color in tissue culture. The demecarium bromide test is a simple, inexpensive, and highly specific screening method for cancer. Demecarium bromide has been shown to be effective in the treatment of glaucoma and as an antiglaucoma agent. It has also been used in the treatment of insulin resistance, although its clinical relevance is not known. Demecarium bromide may also have potential use in degenerative diseases such as Parkinson's disease or Alzheimer's disease.

Formula: C₃₂H₅₂N₄O₄·2Br

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 716.59 g/mol

Ref: 3D-FD38039

Demecarium Bromide

CAS: 56-94-0

Purity: 98%

Molecular weight: 716.6

Ref: 10-F979060