CAS 56124-62-0

Valrubicin

Description:

Valrubicin, with the CAS number 56124-62-0, is an anthracycline derivative primarily used in the treatment of bladder cancer. It is characterized by its ability to intercalate into DNA, thereby inhibiting DNA and RNA synthesis, which ultimately leads to cell death. Valrubicin is administered intravesically, meaning it is delivered directly into the bladder, allowing for localized treatment with reduced systemic toxicity compared to other chemotherapeutic agents. The compound exhibits a unique mechanism of action that involves the generation of free radicals, contributing to its cytotoxic effects. Valrubicin is known for its potential side effects, which may include local irritation, bladder spasms, and systemic effects such as nausea and vomiting. Its efficacy is often evaluated in patients with superficial bladder tumors, and it is considered when other treatment options are not suitable. Overall, Valrubicin represents a targeted approach in cancer therapy, particularly for urothelial carcinoma, highlighting the importance of localized treatment strategies in oncology.

Formula: C₃₄H₃₆F₃NO₁₃

InChI: InChI=1S/C34H36F3NO13/c1-4-5-9-21(40)49-13-20(39)33(47)11-16-24(19(12-33)51-22-10-17(27(41)14(2)50-22)38-32(46)34(35,36)37)31(45)26-25(29(16)43)28(42)15-7-6-8-18(48-3)23(15)30(26)44/h6-8,14,17,19,22,27,41,43,45,47H,4-5,9-13H2,1-3H3,(H,38,46)/t14-,17-,19-,22-,27+,33-/m0/s1

InChI key: InChIKey=ZOCKGBMQLCSHFP-KQRAQHLDSA-N

SMILES: O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(CCCC)=O)=O)(O)C1)[C@H]5C[C@H](NC(C(F)(F)F)=O)[C@H](O)[C@H](C)O5

Synonyms:

• AD 32
• Pentanoic acid, 2-[(2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester
• Pentanoic acid, 2-[(2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester
• Pentanoic acid, 2-[1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester, (2S-cis)-
• Antibiotic AD 32

Valrubicin

CAS: 56124-62-0

Antibiotics nesoi

Formula: C₃₄H₃₆F₃NO₁₃

Color and Shape: Orange Red Crystalline Powder

Molecular weight: 723.21387

Ref: 45-1708730

Valrubicin

CAS: 56124-62-0

Valrubicin

Formula: C₃₄H₃₆F₃NO₁₃

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 723.64

Ref: 54-BUP02515

Valrubicin

CAS: 56124-62-0

Valrubicin

Formula: C₃₄H₃₆F₃NO₁₃

Purity: 98%

Molecular weight: 723.64

Ref: 54-PC108493

Valrubicin

CAS: 56124-62-0

Formula: C₃₄H₃₆F₃NO₁₃

Purity: 95.0 - 103.0 % (dried basis)

Color and Shape: Orange to orange-red crystalline powder

Molecular weight: 723.64

Ref: 7W-GP7911

Valrubicin (Standard)

CAS: 56124-62-0

Valrubicin (Standard) is the standard substance of Valrubicin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC₅₀s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.

Formula: C₃₄H₃₆F₃NO₁₃

Molecular weight: 723.6437

Ref: TM-TMSM-2377

Valrubicin

CAS: 56124-62-0

Formula: C₃₄H₃₆F₃NO₁₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 723.6437

Ref: IN-DA00DEBH

Valrubicin

Controlled Product

CAS: 56124-62-0

Applications Chemotherapy drug used to treat cancer of the bladder.
References Steinberg, G., et al.: J. Urol., 163, 761 (2000); Christmann-Franck, S., et al.: J. Med. Chem., 47, 6840 (2004); McKiernan, J., et al.: J. Clin. Oncol., 24, 3075 (2006); Steinberg, G., et al.: Drug Evaluation, 2, 1009 (2001)

Formula: C₃₄H₃₆F₃NO₁₃

Color and Shape: Neat

Molecular weight: 723.64

Ref: TR-V095600

Valrubicin

CAS: 56124-62-0

2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethyl pentanoate

Formula: C₃₄H₃₆F₃NO₁₃

Purity: 98%

Molecular weight: 723.64

Ref: IN-DG106397

Valrubicin

CAS: 56124-62-0

Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.

Formula: C₃₄H₃₆F₃NO₁₃

Purity: 98.63%

Color and Shape: Solid

Molecular weight: 723.6437

Ref: TM-T7604

Valrubicin

CAS: 56124-62-0

Chemotherapy for bladder cancer; semi-synthetic analog of doxorubicin

Formula: C₃₄H₃₆F₃NO₁₃

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 723.64 g/mol

Ref: 3D-AV28661

Valrubicin

CAS: 56124-62-0

Formula: C₃₄H₃₆F₃NO₁₃

Molecular weight: 723.6

Ref: BE-BePure-27258

Valrubicin

CAS: 56124-62-0

Formula: C₃₄H₃₆F₃NO₁₃

Molecular weight: 723.64

Ref: ST-EA-CP-D104017