CAS 56187-47-4

Cefazedone

Description:

Cefazedone is a broad-spectrum cephalosporin antibiotic, classified under the beta-lactam antibiotics. It is primarily used to treat various bacterial infections by inhibiting bacterial cell wall synthesis, which ultimately leads to cell lysis and death. Cefazedone exhibits a wide range of activity against both Gram-positive and Gram-negative bacteria, making it effective for treating infections caused by a variety of pathogens. The compound is characterized by its stability against certain beta-lactamases, which are enzymes produced by some bacteria to confer resistance to antibiotics. Cefazedone is typically administered via injection and is known for its relatively low toxicity profile. However, like other antibiotics, it may cause side effects such as allergic reactions, gastrointestinal disturbances, and alterations in normal flora. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion, which are crucial for determining dosing regimens. Overall, cefazedone represents an important therapeutic option in the arsenal against bacterial infections, particularly in cases where resistance to other antibiotics is a concern.

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

InChI: InChI=1S/C18H15Cl2N5O5S3/c1-7-22-23-18(33-7)32-6-8-5-31-16-12(15(28)25(16)13(8)17(29)30)21-11(26)4-24-2-9(19)14(27)10(20)3-24/h2-3,12,16H,4-6H2,1H3,(H,21,26)(H,29,30)/t12-,16-/m1/s1

InChI key: InChIKey=VTLCNEGVSVJLDN-MLGOLLRUSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CN3C=C(Cl)C(=O)C(Cl)=C3)=O)C2=O)(SCC1CSC=4SC(C)=NN4)[H]

Synonyms:

• (6R,7R)-7-[[2-(3,5-Dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino}-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R,7R)-
• 7-[[2-(3,5-Dichloro-4-Oxo-1-Piperidyl)Acetyl]Amino]-3-[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Sulfanylmethyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• Cefazedonum
• Refosporen
• Cefazedone

Cefazedone

CAS: 56187-47-4

Cefazedone

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Purity: 99%

Molecular weight: 548.45

Ref: 54-OR1029893

Cefazedone

CAS: 56187-47-4

Cefazedone

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Purity: ≥98%

Molecular weight: 548.44

Ref: 54-BUP14463

Cefazedone

CAS: 56187-47-4

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Color and Shape: Off-White Solid

Molecular weight: 548.43

Ref: 4Z-C-108001

Cefazedone

CAS: 56187-47-4

Ref: 7W-GA8238

Cefazedone

CAS: 56187-47-4

Cefazedone (Refosporen) is a semisynthetic first-generation cephalosporin with activity against Gram-positive and Gram-negative bacteria[1].

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Purity: 99.39%

Color and Shape: Solid

Molecular weight: 548.44

Ref: TM-T8062

Cefazedone

CAS: 56187-47-4

(6R,7R)-7-(2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Purity: 98%

Molecular weight: 548.44

Ref: IN-DG120253

Cefazedone

Controlled Product

CAS: 56187-47-4

Applications Semi-synthetic cephalosporin antibiotic. Antibacterial.
References Vander Stichele, R., et al.: Br. J. Clin. Pharmacol., 58, 419 (2004), Goossens, H., et al.: Lancet, 365, 579 (2005), Ferech, M., et al.: J. Antimicrob. Chemother., 58, 401 (2006),

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Color and Shape: Neat

Molecular weight: 548.44

Ref: TR-C241500

Cefazedone

CAS: 56187-47-4

Cefazedone is an inorganic acid that has been used as an antimicrobial agent. It is a white crystalline powder that is soluble in water and practically insoluble in organic solvents. Cefazedone has been shown to have excellent bactericidal activity against many urinary tract infections, including Escherichia coli, Klebsiella pneumoniae, Enterobacter species, Proteus mirabilis, and Pseudomonas aeruginosa. This drug has also been shown to have good activity against pathogenic bacteria such as Staphylococcus aureus and Streptococcus pyogenes. Cefazedone does not show any adverse effects on human serum or urine samples from healthy volunteers. Toxicological studies on rats showed no evidence of toxicity or teratogenicity due to cefazedone.

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 548.45 g/mol

Ref: 3D-FC19847

CEFAZEDONE

CAS: 56187-47-4

Purity: 99%

Molecular weight: 548.4299927

Ref: 10-F817967

(7S)-Cefazedone

Controlled Product

CAS: 56187-47-4

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Color and Shape: Neat

Molecular weight: 548.443

Ref: TR-C241520

Cefazedone

CAS: 56187-47-4

Formula: C₁₈H₁₅Cl₂N₅O₅S₃

Molecular weight: 548.43

Ref: ST-EA-CP-C209000