CAS 56341-08-3

Mabuterol

Description:

Mabuterol is a synthetic compound classified as a beta-adrenergic agonist, primarily used for its bronchodilator properties in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It functions by stimulating beta-2 adrenergic receptors in the smooth muscle of the airways, leading to relaxation and dilation of bronchial passages, which facilitates easier breathing. Mabuterol is characterized by its relatively selective action on beta-2 receptors, minimizing cardiovascular side effects commonly associated with non-selective beta agonists. The compound is typically administered via inhalation to achieve localized effects in the lungs while reducing systemic exposure. Its pharmacokinetics include a rapid onset of action, making it suitable for acute relief of bronchospasm. As with other beta-agonists, potential side effects may include tremors, palpitations, and increased heart rate, particularly at higher doses. Overall, Mabuterol represents a valuable therapeutic option in managing airway constriction in patients with obstructive pulmonary diseases.

Formula: C₁₃H₁₈ClF₃N₂O

InChI: InChI=1S/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3

InChI key: InChIKey=JSJCTEKTBOKRST-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=CC(C(CNC(C)(C)C)O)=CC(Cl)=C1N

Synonyms:

• 1-[4-Amino-3-Chloro-5-(Trifluoromethyl)Phenyl]-2-(Tert-Butylamino)Ethanol
• 4-Amino-3-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol
• 4-Amino-alpha-((tert-butylamino)methyl)-3-chloro-5-(trifluoromethyl)benzyl alcohol
• Ambuterol
• Benzenemethanol, 4-amino-3-chloro-alpha-(((1,1-dimethylethyl)amino)methyl)-5-(trifluoromethyl)-
• Benzenemethanol, 4-amino-3-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-
• Ccris 5288
• Mabuterol [INN]
• Mabuterolum
• Mabuterolum [INN-Latin]
• PB 868Cl
• Unii-R4K19W6S7Q

4-Amino-3-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol

CAS: 56341-08-3

Formula: C₁₃H₁₈ClF₃N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 310.7430

Ref: IN-DA00EBEG

Mabuterol

CAS: 56341-08-3

Formula: C₁₃H₁₈ClF₃N₂O

Purity: ≥ 98.0%

Color and Shape: Light yellow to orange solid

Molecular weight: 310.74

Ref: 7W-GP0780

Mabuterol free base

CAS: 56341-08-3

Mabuterol: selective β2 agonist, inhibits isoprenaline, affects rat uterus and rabbit jejunum, alters intestinal propulsion.

Formula: C₁₃H₁₈ClF₃N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 310.74

Ref: TM-T27970

GB/T 22286-2008 11 β-Agonists 100 µg/mL in Methanol

Controlled Product

CAS: 21898-19-1, 21912-49-2, 23031-25-6, 51022-70-9, 54238-51-6, 54239-37-1, 54239-39-3, 56341-08-3, 579-56-6, 78982-84-0, 90274-24-1

Color and Shape: Mixture

Ref: 04-A50000096ME

Mabuterol 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 56341-08-3

Formula: C₁₃H₁₈ClF₃N₂O

Color and Shape: Single Solution

Molecular weight: 310.74

Ref: 04-A14659950AL-1000

Mabuterol

CAS: 56341-08-3

Formula: C₁₃H₁₈ClF₃N₂O

Color and Shape: Neat

Molecular weight: 310.74

Ref: 04-C14659950

Mabuterol

CAS: 56341-08-3

Applications A β2-adrenergic agonist, used as a bronchodilator/antiasthmatic
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Murali, S., et al.; Eur. J. Med. Chem., 42, 966 (2007), Nielen, M., et al.: Anal. Bioanal. Chem. 391, 199 (2008), Shao, B., et al.: Food Chem., 114, 1115 (2009),

Formula: C₁₃H₁₈ClF₃N₂O

Color and Shape: Light Yellow To Brown

Molecular weight: 310.74

Ref: TR-M104000

4-Amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol

Controlled Product

CAS: 56341-08-3

4-Amino-3-chloro-a-[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol (4ACBEM) is a fluorescent probe for the detection of intracellular Ca2+ levels. It binds to ryanodine receptors in the plasma membrane and can be used as a marker for Ca2+ mobilization in cells. 4ACBEM is used in flow cytometry and has been shown to bind to human serum albumin and other proteins with high affinity. The pharmacokinetics of 4ACBEM has been studied in rats, showing that it is eliminated by hepatic metabolism. This compound has also been shown to have no toxic effects on fetal bovine liver cells in vitro, although it does exhibit some interactions with the matrix that are dependent on the concentration of Ca2+.

Formula: C₁₃H₁₈ClF₃N₂O

Purity: Min. 95%

Color and Shape: Off-White To Yellow To Orange Solid

Molecular weight: 310.74 g/mol

Ref: 3D-FA24968