CAS 56602-33-6

BOP reagent

Description:

BOP reagent, or benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate, is a chemical compound commonly used in organic synthesis, particularly in peptide coupling reactions. It serves as a coupling agent that facilitates the formation of amide bonds between carboxylic acids and amines. BOP reagent is characterized by its ability to activate carboxylic acids, making them more reactive towards nucleophilic attack by amines. This reagent is typically favored for its mild reaction conditions and compatibility with various functional groups, which minimizes side reactions. It is a white to off-white solid that is soluble in polar organic solvents. Safety precautions should be observed when handling BOP reagent, as it can be hazardous and may cause irritation. Proper storage in a cool, dry place, away from moisture and incompatible substances, is essential to maintain its stability and effectiveness in synthetic applications.

Formula:C₁₂H₂₂N₆OP·F₆P

InChI:InChI=1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1

InChI key:InChIKey=MGEVGECQZUIPSV-UHFFFAOYSA-N

SMILES:[P+](ON1C=2C(N=N1)=CC=CC2)(N(C)C)(N(C)C)N(C)C.[P+5]([F-])([F-])([F-])([F-])([F-])[F-]

Synonyms:

(1H-benzotriazol-1-yloxy)[tris(dimethylamino)]phosphonium hexafluorophosphate
(Benzotriazol-1-yloxy)tris(dimethylamino) hexafluorophosphate
(Boranyloxy)Phosphane
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
1H-Benzotriazole, 1-hydroxy-, phosphorus complex
2-(1H-Benzotriazol-1-yl)tris(dimethylamino)phosphonium hexafluorophosphate
BOP
BOP hexafluorophosphate
BOP reagent
Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate
Castro reagent
Castro's reagent
Le BOP
Methanamine, N-methyl-, phosphorus complex
Phosphate(1-), hexafluoro-, (T-4)-(1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)phosphorus(1+)
Phosphorus(1+), (1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)-, (T-4)-, hexafluorophosphate(1-)
See more synonyms

Purity (%)

100

Found 11 products.

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1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate [Coupling Reagent for Peptide]
CAS:
- 56602-33-6
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:>98.0%(HPLC)
Color and Shape:White to Light yellow powder to crystal
Molecular weight:442.29
Ref: 3B-B1651
5g
28.00€
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25g
72.00€
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100g
173.00€
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1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 98%
CAS:
- 56602-33-6
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecarobox
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:98%
Color and Shape:Crystalline powder, White
Molecular weight:442.29
Ref: 02-A16140
25g
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5g
83.00€
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[(1H-Benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphate
CAS:
- 56602-33-6
[(1H-Benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphate
Formula:C₁₂H₂₂N₆OP·PF₆
Purity:≥95%
Color and Shape:Solid-Powder
Molecular weight:442.28062
Ref: 54-PC2519
25g
32.00€
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100g
56.00€
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(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
CAS:
- 56602-33-6
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:98%
Color and Shape:Solid
Molecular weight:442.2806
Ref: IN-DA0032D4
10g
20.00€
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25g
23.00€
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100g
55.00€
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Benzotriazol-1-yl-oxy-tris(dimethylamino) phosphonium hexafluorophosphate (BOP Reagent)
CAS:
- 56602-33-6
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:≥ 98.0%
Color and Shape:White to beige or light-yellow powder to crystals
Molecular weight:442.29
Ref: 7W-GE5235
ne
To inquire
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Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate
CAS:
- 56602-33-6
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:98.0%
Color and Shape:Solid
Molecular weight:442.287
Ref: 10-F009018
5g
30.00€
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25g
30.00€
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50g
37.00€
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100g
52.00€
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500g
208.00€
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BOP Reagent
CAS:
- 56602-33-6
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:98%
Molecular weight:442.28
Ref: IN-DG21506
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BOP Reagent
CAS:
- 56602-33-6
BOP Reagent is a reagent that reacts with the phosphate group of dinucleotide phosphates, such as those found in DNA and RNA. It can be used for structural analysis and to determine the presence of nucleic acids in human serum or other biological samples. The BOP Reagent binds to the phosphate group by means of intramolecular hydrogen bonding. This reaction generates a transient, covalently-bound enzyme-substrate complex that can be detected by fluorescence probe.
Formula:C₁₂H₂₂N₆OF₆P₂
Purity:Min. 95%
Molecular weight:442.29 g/mol
Ref: 3D-KBP-1060-PI
5g
186.00€
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25g
222.00€
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100g
479.00€
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BOP
CAS:
- 56602-33-6
BOP, also known with the name of Castro’s reagent, is a phosphonium coupling reagent used for peptide synthesis. BOP can be employed in presence of a base such as triethylamine or Hünig’s base and forms HOBt in situ, which then generates an activated ester. BOP is a very effective coupling reagent, achieving high yields, low epimerisation and high conversion rates. However, it forms the extremely toxic and carcinogenic HMPA in situ, therefore the equally efficient pyrrolidino derivative PyBOP was introduced, which leads to a less toxic by-product.
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:Min. 98 Area-%
Color and Shape:White Off-White Powder
Molecular weight:442.28 g/mol
Ref: 3D-FB01762
250g
384.00€
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500g
547.00€
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1kg
842.00€
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2kg
1,343.00€
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5kg
2,735.00€
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Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 56602-33-6
Applications A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kenner, G.W., Seely, J., J. Am. Chem. Soc., 94, 3259 (1972), Castro, B., et al.: Tetrahedron Lett., 1219 (1975)
Formula:C₁₂H₂₂N₆OP·F₆P
Color and Shape:Neat
Molecular weight:442.28
Ref: TR-B207000
5g
81.00€
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25g
162.00€
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BOP Reagent extrapure AR, 98%
CAS:
- 56602-33-6
Formula:C₁₂H₂₂F₆N₆OP₂
Purity:min. 98.0%
Color and Shape:White to pale yellow, Crystalline powder, Crystalline powder
Molecular weight:442.29
Ref: SR-59946
5g
Discontinued
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25g
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100g
Discontinued
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Discontinued product