CAS 56995-20-1

Flupirtine

Description:

Flupirtine is a non-opioid analgesic and muscle relaxant that is primarily used for the treatment of pain and discomfort. It is classified as a selective neuronal potassium channel opener, which contributes to its analgesic properties by stabilizing neuronal excitability and reducing the release of excitatory neurotransmitters. The chemical structure of flupirtine includes a phenylpyridine moiety, which is essential for its pharmacological activity. It exhibits a favorable pharmacokinetic profile, with good oral bioavailability and a relatively long half-life, allowing for less frequent dosing. Flupirtine is known for its minimal side effects compared to traditional analgesics, making it a valuable option for patients with chronic pain conditions. However, it is important to note that flupirtine has been associated with liver toxicity, leading to restrictions in its use in some countries. Overall, flupirtine represents a unique approach to pain management, particularly in cases where conventional analgesics may not be suitable.

Formula: C₁₅H₁₇FN₄O₂

InChI: InChI=1S/C15H17FN4O2/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20)

InChI key: InChIKey=JUUFBMODXQKSTD-UHFFFAOYSA-N

SMILES: N(C(OCC)=O)C1=C(N)N=C(NCC2=CC=C(F)C=C2)C=C1

Synonyms:

• 260-503-8
• 56995-20-1
• Carbamic acid, N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-, ethyl ester
• Carbamic acid, [2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-, ethyl ester
• D 9998
• Ethyl {2-amino-6-[(4-fluorobenzyl)amino]pyridin-3-yl}carbamate
• Katadolon
• Trancopal Dolo
• [2-Amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester
• [2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic Acid Ethyl Ester
• Flupirtine

Flupirtine Maleate Salt

CAS: 56995-20-1, 75507-68-5

Formula: C₁₅H₁₇FN₄O₂·C₄H₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 420.40

Ref: 3B-F0736

Flupirtine

CAS: 56995-20-1

Color and Shape: Neat

Ref: 61-FOR1245.04

Ethyl (2-amino-6-((4-fluorobenzyl)amino)pyridin-3-yl)carbamate

CAS: 56995-20-1

Ethyl (2-amino-6-((4-fluorobenzyl)amino)pyridin-3-yl)carbamate

Purity: 98%

Molecular weight: 304.33g/mol

Ref: 54-PC1005870

Flupirtine

Controlled Product

CAS: 56995-20-1

Formula: C₁₅H₁₇FN₄O₂

Color and Shape: White Solid

Molecular weight: 304.32

Ref: 86-MM1245.04

Flupirtine

CAS: 56995-20-1

Flupirtine(D 9998) is a selective neuronal potassium channel opener as well as shows properties of NMDA receptor antagonist.

Formula: C₁₅H₁₇FN₄O₂

Color and Shape: Solid

Molecular weight: 304.32

Ref: TM-T60705

Flupirtine-d5

Controlled Product

CAS: 56995-20-1

Applications Flupirtine-d5, is the labeled analogue of Flupirtine, an Analgesic, having substituted pyridine with central analgesic properties.
References Vaupel, D., et al.: Eur. J. Pharmacol., 162, 447 (1989), Nickel, B., et al.: Arzneim.-Forsch., 40, 909 (1990), Lunemann, J., et al.: J. Immunol., 168, 4881 (2002),

Formula: C₁₅H₁₂D₅FN₄O₂

Color and Shape: Off White Solid

Molecular weight: 309.35

Ref: TR-F598513

Flupirtine

CAS: 56995-20-1

Flupirtine is a bicyclic heterocycle that has been shown to have a number of biological properties. It has been used as a plate test for the determination of the bacterial sensitivity to flupirtine. Flupirtine also affects locomotor activity and induces neuronal death in rats by inhibiting mitochondrial membrane depolarization. The drug is cell-specific with respect to its effect on transcriptional regulation and cytosolic calcium ion concentration.

Formula: C₁₅H₁₇FN₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 304.32 g/mol

Ref: 3D-FF100721

Flupirtine

Controlled Product

CAS: 56995-20-1

Formula: C₁₅H₁₇FN₄O₂

Color and Shape: Neat

Molecular weight: 304.32

Ref: TR-F312130