CAS 57-63-6

Ethinylestradiol

Description:

Ethinylestradiol is a synthetic estrogen, primarily used in hormonal contraceptives and hormone replacement therapy. It is characterized by its potent estrogenic activity, which is significantly stronger than that of natural estradiol. Ethinylestradiol is a white to off-white crystalline powder that is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. Its chemical formula is C20H24O2, and it has a molecular weight of approximately 296.4 g/mol. The compound features an ethynyl group at the C17 position, which enhances its oral bioavailability and metabolic stability compared to natural estrogens. Ethinylestradiol acts by binding to estrogen receptors, influencing various physiological processes, including the regulation of the menstrual cycle and the development of secondary sexual characteristics. Due to its estrogenic effects, it can also have side effects, including an increased risk of thromboembolic events. As a widely used pharmaceutical agent, it is essential to consider its pharmacokinetics, potential interactions, and contraindications in clinical applications.

Formula: C₂₀H₂₄O₂

InChI: InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key: InChIKey=BFPYWIDHMRZLRN-SLHNCBLASA-N

SMILES: C[C@@]12[C@]([C@]3([C@](CC1)(C=4C(CC3)=CC(O)=CC4)[H])[H])(CC[C@]2(C#C)O)[H]

Synonyms:

• (17Alpha)-17-Ethynylestra-1,3,5(10)-Triene-3,17-Diol
• (17Beta)-17-Ethynylestra-1,3,5(10)-Triene-3,17-Diol
• (17α)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol
• (8Alpha,13Alpha,17Beta)-17-Ethynylestra-1,3,5(10)-Triene-3,17-Diol
• (8Xi,9Xi,14Xi,17Beta)-17-Ethynylestra-1,3,5(10)-Triene-3,17-Diol
• 17-Ethinyl-3,17-estradiol
• 17-Ethinylestradiol
• 17-Ethynyl Estradiol
• 17-Ethynyl-3,17-dihydroxy-1,3,5-oestratriene
• 17-Ethynylestra-1,3,5(10)-Triene-3,17-Diol
• 17-Ethynylestra-1,3,5(10)-triene-3,17β-diol
• 17-Ethynylestradiol
• 17-Nor-17α-pregna-1,3,5-(10)-trien-20-yne-3,17-diol
• 17A-Ethynyl-1,3,5(10)-Estratriene-3,17B-Diol
• 17Alpha-Ethynyl-3,17-Dihydroxy-Delta-(Sup1,3,5)-Estratriene
• 17alpha-Ethynyl-3-hydroxy-1,3,5(10)-estratrien-17beta-ol
• 17α-Ethinyl estradiol (EE2)
• 17α-Ethinyl-1,3,5(10)-estratriene-3,17-diol
• 17α-Ethinyl-17β-estradiol
• 17α-Ethinyl-3,17-dihydroxy-Δ1,3,5-estratriene
• 17α-Ethinyl-3,17-dihydroxy-Δ^1,3,5-estratriene
• 17α-Ethinylestra-1,3,5(10)-triene-3,17β-diol
• 17α-Ethinylestradiol
• 17α-Ethynylestra-1,3,5(10)-triene-3,17β-diol
• 17α-Ethynylestra-3,17β-diol
• 17α-Ethynylestradiol
• 19-Nor-17Alpha-Pregna-1,3,5(10)-Trien-20-Yne-3,17,Diol
• 19-Nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol
• 19-Nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17β-diol
• 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-
• 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17α)-
• 3,17Beta-Dihydroxy-17Alpha-Ethynyl-1,3,5(10)-Estratriene
• Acetylene estradiol
• Amenoron
• Anovlar
• Chee-O-Gen
• Chee-O-Genf
• Diognat-E
• Diogyn-E
• Dyloform
• EE
• Esteed
• Estigyn
• Estinyl
• Eston-E
• Estone
• Estoral
• Estoral (Orion)
• Estorals
• Estra-1,3,5(10)-Triene-3,17Beta-Diol, 17Alpha-Ethynyl-
• Estradiol, 17-ethynyl-
• Estroals
• Ethidol
• Ethinoral
• Ethinyl estradiol
• Ethinyloestradiol
• Ethynyl estradiol
• Ethynylestradiol
• Ethynyloestradiol
• Eticyclin
• Eticyclol
• Etinestrol
• Etinestryl
• Etinilestradiol
• Etinoestryl
• Etistradiol
• Feminone
• Follicoral
• Ginestrene
• Gynofen
• Inestra
• Linoral
• Lynoral
• Menolyn
• Microfollin
• Neo-Estrone
• Novestrol
• Novinet
• Nsc 10973
• Oradiol
• Orestralyn
• Palonyl
• Perovex
• Primogyn
• Primogyn C
• Primogyn C(Or M)
• Primogyn M
• Progynon C
• Prosexol
• Roldiol
• Spanestrin

Ethynyl Estradiol

Controlled Product

CAS: 57-63-6

Applications Ethynyl Estradiol, an oral contraceptive (1), is a synthetic steroid with high oral estrogenic potency. Used in estrogen replacement therapy. (2)This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Koetsawang, S. et al.: Contraception. 1982 March:25(3) p231-2412. Cuttler, L. et al.: J. Endocrinol. Metab. 1985 Jun;60(6):1087-92.

Formula: C₂₀H₂₄O₂

Color and Shape: Off-White

Molecular weight: 296.40

Ref: TR-E685100

(1S,10R,11S,14R,15S)-14-ethynyl-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol

CAS: 57-63-6

Formula: C₂₀H₂₄O₂

Purity: 98%

Color and Shape: Liquid

Molecular weight: 296.41

Ref: 10-F358085

Ethynyl Estradiol-d7

Controlled Product

CAS: 57-63-6

Formula: C₂₀D₇H₁₇O₂

Color and Shape: Neat

Molecular weight: 303.447

Ref: TR-E685103

Ethynylestradiol

CAS: 57-63-6

Ethynylestradiol is a synthetic estrogen that is used in hormone replacement therapy. It belongs to the group of estrogens and has been shown to be a potent inhibitor of ovarian activity. Ethinyl estradiol is metabolized through catechol-O-methyltransferase (COMT) and sulfotransferases, which leads to an increased rate constant for its clearance from plasma. The drug also has interactions with other drugs, such as protease inhibitors, which may lead to disease activity or toxicity in the liver. Ethynylestradiol binds specifically to bcl-2 protein, which may be related to its anti-inflammatory properties.

Formula: C₂₀H₂₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 296.4 g/mol

Ref: 3D-FE23175