CAS 57-94-3: Tubocurarine

Description:Tubocurarine is a chemical compound classified as a neuromuscular blocking agent, primarily derived from the bark of certain South American plants, notably Chondrodendron tomentosum. It acts as a competitive antagonist at the neuromuscular junction by blocking the action of acetylcholine at nicotinic receptors on the motor end plate, leading to muscle paralysis. Tubocurarine is characterized by its quaternary ammonium structure, which contributes to its pharmacological properties. It is typically administered intravenously and has a relatively short duration of action, making it useful in surgical procedures to facilitate muscle relaxation. The compound is also known for its potential side effects, including hypotension and respiratory depression, due to its effects on autonomic ganglia and histamine release. While tubocurarine has historical significance in medicine, it has largely been replaced by newer neuromuscular blockers with improved safety profiles and fewer side effects. Its use today is primarily of historical interest and in specific clinical settings where its unique properties may be advantageous.

Formula:C₃₇H₄₁N₂O₆·ClH·Cl

InChI:InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1

InChI key:InChIKey=GXFZCDMWGMFGFL-KKXMJGKMSA-N

SMILES:[Cl-].Cl.OC1=CC=C2C=C1OC=3C=C4C(=CC3OC)CCN(C)C4CC5=CC=C(OC=6C(O)=C(OC)C=C7C6C(C2)[N+](C)(C)CC7)C=C5

Synonyms:
(+)-Tubocurarine
(+)-Tubocurarine dichloride
(+)-Tubocurarine hydrochloride
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride (1:1:1), (13aR,25aS)-
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, (13aR,25aS)-
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, [13aR-(13aR*,25aS*)]-
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, tubocuraranium deriv.
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride (1:1:1), (13aR,25aS)-
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, (13aR,25aS)-
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, [13aR-(13aR*,25aS*)]-
See more synonyms
6,6'-Dimethoxy-2,2',2'-Trimethyltubocuraran-2'-Ium-7',12'-Diol Chloride
7',12'-Dihydroxy-6,6'-Dimethoxy-2,2',2'-Trimethyltubocuraran-2,2'-Diium Dichloride
<span class="text-smallcaps">D</span>-Tubocurarine
Amelizol
Amerizol
Chlorure De Tubocurarine
Cloruro De Tubocurarina
Curarin HAF
Delacurarine
Dextrotubocurarine chloride
Intocostrine T
Introcostrin
Tubadil
Tubarine
Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-, chloride, hydrochloride
Tubocuraranium, 7′,12′-dihydroxy-6,6′-dimethoxy-2,2′,2′-trimethyl-, chloride, hydrochloride
Tubocurarinchlorid
Tubocurarine Chloride
Tubocurarine, chloride, hydrochloride, (+)-
d-(+)-Tubocurarine chloride
d-Paracurarine chloride
d-Tubocurarine
d-Tubocurarine dichloride
d-Tubocurarine hydrochloride

Found 2 products.

Brand	Product data	Purity	Price range	Estimated delivery
	D-Tubocurarine chloride REF: 3D-FT65013CAS: 57-94-3	Min. 95%	179.00 €~1,067.00 €	Fri 25 Apr 25
	Tubocurarine Chloride Pentahydrate REF: 3B-C0433CAS: 57-94-3 57-95-4 6989-98-6	>98.0%(T)(HPLC)	- - -	Discontinued product