CAS 57-94-3

Tubocurarine

Description:

Tubocurarine is a chemical compound classified as a neuromuscular blocking agent, primarily derived from the bark of certain South American plants, notably Chondrodendron tomentosum. It acts as a competitive antagonist at the neuromuscular junction by blocking the action of acetylcholine at nicotinic receptors on the motor end plate, leading to muscle paralysis. Tubocurarine is characterized by its quaternary ammonium structure, which contributes to its pharmacological properties. It is typically administered intravenously and has a relatively short duration of action, making it useful in surgical procedures to facilitate muscle relaxation. The compound is also known for its potential side effects, including hypotension and respiratory depression, due to its effects on autonomic ganglia and histamine release. While tubocurarine has historical significance in medicine, it has largely been replaced by newer neuromuscular blockers with improved safety profiles and fewer side effects. Its use today is primarily of historical interest and in specific clinical settings where its unique properties may be advantageous.

Formula: C₃₇H₄₁N₂O₆·ClH·Cl

InChI: InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1

InChI key: InChIKey=GXFZCDMWGMFGFL-KKXMJGKMSA-N

SMILES: OC1=C2C=3[C@@](CC=4C=C(OC=5C=C6[C@](CC=7C=CC(O2)=CC7)(N(C)CCC6=CC5OC)[H])C(O)=CC4)([N+](C)(C)CCC3C=C1OC)[H].[Cl-].Cl

Synonyms:

• (+)-Tubocurarine
• (+)-Tubocurarine dichloride
• (+)-Tubocurarine hydrochloride
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride (1:1:1), (13aR,25aS)-
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, (13aR,25aS)-
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, [13aR-(13aR*,25aS*)]-
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, tubocuraranium deriv.
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride (1:1:1), (13aR,25aS)-
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, (13aR,25aS)-
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, chloride, hydrochloride, [13aR-(13aR*,25aS*)]-
• 6,6'-Dimethoxy-2,2',2'-Trimethyltubocuraran-2'-Ium-7',12'-Diol Chloride
• 7',12'-Dihydroxy-6,6'-Dimethoxy-2,2',2'-Trimethyltubocuraran-2,2'-Diium Dichloride
• <span class="text-smallcaps">D</span>-Tubocurarine
• Amelizol
• Amerizol
• Chlorure De Tubocurarine
• Cloruro De Tubocurarina
• Curarin HAF
• Delacurarine
• Dextrotubocurarine chloride
• Intocostrine T
• Introcostrin
• Tubadil
• Tubarine
• Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-, chloride, hydrochloride
• Tubocuraranium, 7′,12′-dihydroxy-6,6′-dimethoxy-2,2′,2′-trimethyl-, chloride, hydrochloride
• Tubocurarinchlorid
• Tubocurarine Chloride
• Tubocurarine, chloride, hydrochloride, (+)-
• d-(+)-Tubocurarine chloride
• d-Paracurarine chloride
• d-Tubocurarine
• d-Tubocurarine dichloride

D-Tubocurarine chloride

CAS: 57-94-3

D-Tubocurarine chloride is a neuromuscular blocking agent, which is a naturally occurring alkaloid derived from the bark and stems of Chondrodendron tomentosum, a plant native to South America. This compound functions by competitively binding to nicotinic acetylcholine receptors at the neuromuscular junction, inhibiting acetylcholine from transmitting nerve impulses to muscles. The result is skeletal muscle relaxation, which is crucial during surgical procedures where muscle paralysis is required for intubation or to ensure the absence of movement.

Formula: C₃₇H₄₂Cl₂N₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 681.64 g/mol

Ref: 3D-FT65013

Tubocurarine Chloride

CAS: 57-94-3

Color and Shape: Neat

Ref: 61-FOR1651.00