CAS 570406-98-3

Avatrombopag

Description:

Avatrombopag is a synthetic small molecule classified as a thrombopoietin receptor agonist. It is primarily used in the treatment of thrombocytopenia, particularly in patients with chronic liver disease undergoing procedures. The compound works by stimulating the thrombopoietin receptor, leading to increased platelet production in the bone marrow. Avatrombopag is characterized by its oral bioavailability, allowing for convenient administration. Its chemical structure includes specific functional groups that contribute to its pharmacological activity and selectivity for the thrombopoietin receptor. The substance has undergone extensive clinical trials to evaluate its efficacy and safety profile, demonstrating a favorable outcome in increasing platelet counts with a manageable side effect profile. Additionally, it is important to note that Avatrombopag is subject to regulatory approval and guidelines for use in various clinical settings. As with any medication, monitoring for potential adverse effects and interactions with other drugs is essential during treatment.

Formula: C₂₉H₃₄Cl₂N₆O₃S₂

InChI: InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)

InChI key: InChIKey=OFZJKCQENFPZBH-UHFFFAOYSA-N

SMILES: N(C(=O)C=1C=C(Cl)C(=NC1)N2CCC(C(O)=O)CC2)C3=NC(=C(S3)N4CCN(CC4)C5CCCCC5)C6=CC(Cl)=CS6

Synonyms:

• 1-(3-Chlor-5-{[4-(4-chlor-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidincarbons�ure [German]
• 1-(3-Chloro-5-{[4-(4-Chlorothiophen-2-Yl)-5-(4-Cyclohexylpiperazin-1-Yl)Thiazol-2-Yl]Carbamoyl}Pyridin-2-Yl)Piperidine-4-Carboxylic Acid
• 1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid
• 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid
• 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid
• 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-
• Akr 501
• As 1670542
• Doptelet
• E-5501
• Crenolanib Besylate
• AVATROMBOPAG
• AKR-501 USP/EP/BP
• AKR-501; YM477; E5501; AS 1670542
• Avatrombopag(AS1670542)
• Avatrombopag Base,Avatrombopag
• 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbo
• Avatrombopag (AKR-501)

AKR-501

CAS: 570406-98-3

Formula: C₂₉H₃₄Cl₂N₆O₃S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 649.6547

Ref: IN-DA00ECF7

Avatrombopag

CAS: 570406-98-3

Avatrombopag

Purity: ≥98%

Molecular weight: 649.65g/mol

Ref: 54-BUP07380

Avatrombopag (AKR-501)

CAS: 570406-98-3

Formula: C₂₉H₃₄Cl₂N₆O₃S₂

Color and Shape: Off-White Solid

Molecular weight: 649.65

Ref: 4Z-A-315001

Avatrombopag-d8 HCl

CAS: 570406-98-3

Formula: C₂₉H₂₆D₈Cl₂N₆O₃S₂·HCl

Color and Shape: Pale Gray Solid

Molecular weight: 657.70 36.46

Ref: 4Z-A-315002

Avatrombopag

CAS: 570406-98-3

Purity: 98%

Molecular weight: 649.650024414063

Ref: 10-F787596

Avatrombopag

CAS: 570406-98-3

Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation

Formula: C₂₉H₃₄Cl₂N₆O₃S₂

Purity: 99.01% - 99.63%

Color and Shape: Solid

Molecular weight: 649.65

Ref: TM-T7417