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CAS 570406-98-3

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Avatrombopag

Description:
Avatrombopag is a synthetic small molecule classified as a thrombopoietin receptor agonist. It is primarily used in the treatment of thrombocytopenia, particularly in patients with chronic liver disease undergoing procedures. The compound works by stimulating the thrombopoietin receptor, leading to increased platelet production in the bone marrow. Avatrombopag is characterized by its oral bioavailability, allowing for convenient administration. Its chemical structure includes specific functional groups that contribute to its pharmacological activity and selectivity for the thrombopoietin receptor. The substance has undergone extensive clinical trials to evaluate its efficacy and safety profile, demonstrating a favorable outcome in increasing platelet counts with a manageable side effect profile. Additionally, it is important to note that Avatrombopag is subject to regulatory approval and guidelines for use in various clinical settings. As with any medication, monitoring for potential adverse effects and interactions with other drugs is essential during treatment.
Formula:C29H34Cl2N6O3S2
InChI:InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)
InChI key:InChIKey=OFZJKCQENFPZBH-UHFFFAOYSA-N
SMILES:N(C(=O)C=1C=C(Cl)C(=NC1)N2CCC(C(O)=O)CC2)C3=NC(=C(S3)N4CCN(CC4)C5CCCCC5)C6=CC(Cl)=CS6
Synonyms:
  • 1-(3-Chlor-5-{[4-(4-chlor-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidincarbons�ure [German]
  • 1-(3-Chloro-5-{[4-(4-Chlorothiophen-2-Yl)-5-(4-Cyclohexylpiperazin-1-Yl)Thiazol-2-Yl]Carbamoyl}Pyridin-2-Yl)Piperidine-4-Carboxylic Acid
  • 1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid
  • 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid
  • 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid
  • 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-
  • Akr 501
  • As 1670542
  • Doptelet
  • E-5501
  • See more synonyms
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