CAS 57132-53-3

Proglumetacin

Description:

Proglumetacin is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of medications known as indole acetic acids. It is primarily used for its analgesic and anti-inflammatory properties, making it effective in treating conditions such as pain and inflammation associated with various disorders. The chemical structure of proglumetacin features a unique combination of functional groups that contribute to its pharmacological activity. It is typically administered in the form of its sodium salt, which enhances its solubility and bioavailability. Proglumetacin works by inhibiting the cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain and inflammation. The substance is characterized by its moderate lipophilicity, which influences its absorption and distribution in the body. As with other NSAIDs, proglumetacin may have side effects, including gastrointestinal discomfort and potential cardiovascular risks, necessitating careful consideration in its clinical use. Overall, proglumetacin represents a valuable option in the management of pain and inflammatory conditions.

Formula: C₄₆H₅₈ClN₅O₈

InChI: InChI=1/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)

InChI key: InChIKey=PTXGHCGBYMQQIG-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(OCCN3CCN(CCCOC(CCC(C(N(CCC)CCC)=O)NC(=O)C4=CC=CC=C4)=O)CC3)=O)=C1C)=CC(OC)=CC2)C5=CC=C(Cl)C=C5

Synonyms:

• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester
• 3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl DL-4-benzamido-N,N-dipropylglutaramate 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate (ester)
• 3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N~2~-benzoyl-N,N-dipropyl-alpha-glutaminate
• Proglumetacin [INN:BAN]
• Proglumetacina [INN-Spanish]
• Proglumetacine
• Proglumetacine [INN-French]
• Proglumetacinum
• Proglumetacinum [INN-Latin]
• Proglumetacin
• Proglumetacin
• PROGLUMETACIN MALEATE
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester

Proglumetacin Dioxalate

Controlled Product

CAS: 57132-53-3

Applications Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug.
References Garcia-March, F., et al.: J. Pharm. Pharmacol., 47, 232 (1995), Jaen-Oltra, J., et al.: J. Med. Chem., 43, 1143 (2000),

Formula: C₅₀H₆₂ClN₅O₁₆

Color and Shape: Neat

Molecular weight: 1024.5

Ref: TR-P755940

Proglumetacin

CAS: 57132-53-3

Formula: C₄₆H₅₈ClN₅O₈

Molecular weight: 844.43

Ref: ST-EA-CP-P474000