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CAS 5714-08-9

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D-Triiodothyronine

Description:
D-Triiodothyronine, commonly known as T3, is a thyroid hormone that plays a crucial role in regulating metabolism, growth, and development in the body. It is a derivative of thyroxine (T4) and contains three iodine atoms, which are essential for its biological activity. T3 is synthesized in the thyroid gland and is more potent than T4, influencing various physiological processes, including heart rate, body temperature, and energy expenditure. The chemical structure of D-Triiodothyronine includes a phenolic ring and an amine group, contributing to its solubility in lipids and its ability to cross cell membranes. T3 exerts its effects primarily by binding to nuclear receptors, leading to the modulation of gene expression. Its levels in the bloodstream are tightly regulated by feedback mechanisms involving the hypothalamus and pituitary gland. Abnormal levels of T3 can lead to various health issues, including hyperthyroidism or hypothyroidism, highlighting its importance in endocrine function and overall metabolic health.
Formula:C15H12I3NO4
InChI:InChI=1/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m1/s1
InChI key:InChIKey=AUYYCJSJGJYCDS-GFCCVEGCSA-N
SMILES:O(C1=C(I)C=C(C[C@H](C(O)=O)N)C=C1I)C2=CC(I)=C(O)C=C2
Synonyms:
  • (+)-Triiodothyronine
  • 3,3′,5-Triiodo-<span class="text-smallcaps">D</span>-thyronine
  • 3,5,3′-<span class="text-smallcaps">D</span>-Triiodothyronine
  • 3,5,3′-Triiodo-<span class="text-smallcaps">D</span>-thyronine
  • <span class="text-smallcaps">D</span>-3,5,3′-Triiodothyronine
  • <span class="text-smallcaps">D</span>-Triiodothyronin
  • <span class="text-smallcaps">D</span>-Triiodothyronine
  • <span class="text-smallcaps">D</span>-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-
  • Alanine, 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, <span class="text-smallcaps">D</span>-
  • Detrothyronin
  • See more synonyms
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