CAS 57432-61-8

Methergine

Description:

Methergine, known chemically as methylergometrine, is a semi-synthetic derivative of ergot alkaloids, primarily used in obstetrics to prevent or treat postpartum hemorrhage due to uterine atony. Its CAS number is 57432-61-8. Methergine acts as a potent uterine stimulant, promoting contractions and facilitating the expulsion of the placenta. The substance is typically administered via intramuscular or oral routes, depending on the clinical scenario. It has a relatively short half-life, necessitating careful monitoring of dosage and timing. Common side effects may include hypertension, nausea, and headache, reflecting its vasoconstrictive properties. Due to its pharmacological effects, Methergine is contraindicated in patients with hypertension or cardiovascular disease. Its mechanism of action involves agonistic activity at serotonin and adrenergic receptors, leading to increased uterine tone and reduced blood loss during and after childbirth. As with any medication, it is essential to use Methergine under medical supervision to ensure safety and efficacy.

Formula: C₂₀H₂₅N₃O₂·C₄H₄O₄

InChI: InChI=1/C20H25N3O2.C4H4O4/c1-3-14(11-24)22-20(25)13-7-16-15-5-4-6-17-19(15)12(9-21-17)8-18(16)23(2)10-13;5-3(6)1-2-4(7)8/h4-7,9,13-14,18,21,24H,3,8,10-11H2,1-2H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/t13-,14+,18-;/m1./s1

SMILES: CN1[C@]2(C(C=3C=4C(C2)=CNC4C=CC3)=C[C@@H](C(N[C@@H](CC)CO)=O)C1)[H].C(=C\C(O)=O)\C(O)=O

Synonyms:

• (8beta)-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-9,10-didehydroergoline-8-carboxamide (2Z)-but-2-enedioate (salt)
• Basofortina
• Erezin
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8β)-, (2Z)-2-butenedioate (1:1) (salt)
• Ergonovine, methyl-, compd. with maleic acid
• Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv.
• Metenarin
• Methergin
• Methergine
• Methyl ergometrine maleate
• Methylergobasine maleate
• Methylergometrine Maleate
• Ryegonovin
• Spametrin F

METHYLERGOMETRINE FOR SYSTEM SUITABILITY CRS

CAS: 57432-61-8

METHYLERGOMETRINE FOR SYSTEM SUITABILITY CRS

Formula: C₂₄H₂₉N₃O₆

Color and Shape: Powder

Molecular weight: 455.5036

Ref: 41-Y0000777

METHYLERGOMETRINE MALEATE CRS

CAS: 57432-61-8

METHYLERGOMETRINE MALEATE CRS

Formula: C₂₄H₂₉N₃O₆

Color and Shape: Powder

Molecular weight: 455.5036

Ref: 41-Y0000776

Methylergonovine Maleate

CAS: 57432-61-8

Alkaloids of rye ergot and their derivatives; salts thereof, nesoi

Formula: C₂₀H₂₅N₃O₂·C₄H₄O₄

Color and Shape: White Crystalline Powder

Molecular weight: 455.20564

Ref: 45-1430000

Methylergonovine maleate salt

CAS: 57432-61-8

Formula: C₂₀H₂₅N₃O₂·C₄H₄O₄

Molecular weight: 455.50

Ref: 7W-GL9014

Methylergonovine Maleate (Methylergometrine Maleate)

CAS: 57432-61-8

Formula: C₂₀H₂₅N₃O₂·C₄H₄O₄

Molecular weight: 339.44 116.07

Ref: 4Z-M-130001

Methylergometrine Maleate RS

CAS: 57432-61-8

Color and Shape: White To Pale Yellow Solid Crystalline Powder

Ref: 2K-1161000021

Methyl Ergonovine Maleate Salt

CAS: 57432-61-8

Formula: C₂₀H₂₅N₃O₂·C₄H₄O₄

Color and Shape: Beige To Light Brown

Molecular weight: 455.50

Ref: TR-M304600

Methyl Ergonovine-d5 Maleate Salt

Controlled Product

CAS: 57432-61-8

Formula: C₂₄H₂₄D₅N₃O₆

Color and Shape: Neat

Molecular weight: 460.53

Ref: TR-M304602

Methyl Ergonovine-D7 Maleate Salt

Controlled Product

CAS: 113-42-8, 57432-61-8

Formula: C₂₀H₁₈D₇N₃O₂·(C₄H₄O₄)

Color and Shape: Neat

Molecular weight: 462.54

Ref: TR-M304603

Methyl Ergonovine-D6 Maleate Salt

Controlled Product

CAS: 113-42-8, 57432-61-8

Formula: C₂₀H₁₉D₆N₃O₂·(C₄H₄O₄)

Color and Shape: Neat

Molecular weight: 461.54

Ref: TR-M304601

Methylergonovine maleate salt

Controlled Product

CAS: 57432-61-8

Methylergonovine maleate salt is a prodrug of methylergometrine. It is a potent vasoconstrictor that has been used to treat severe hypertension, although it has been largely replaced by other drugs such as hydralazine and minoxidil. Methylergonovine maleate salt is also used to prevent and treat pulmonary edema in heart failure patients. This drug binds to the alpha-adrenergic receptor on vascular smooth muscle cells, leading to an increase in intracellular calcium ion concentration and vasoconstriction. The pharmacokinetics of methylergonovine maleate salt have been studied in healthy subjects using a pharmacokinetics study with LC-MS/MS method. Results show that this drug has low potency, with an elimination half-life of about 2 hours. Methylergonovine maleate salt is metabolized by esterases or glucuronidases, oxidized by cytochrome P

Formula: C₂₄H₂₉N₃O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 455.5 g/mol

Ref: 3D-FM25836

Methylergometrine Maleate

CAS: 57432-61-8

Formula: C₂₀H₂₅N₃O₂C₄H₄O₄

Molecular weight: 339.4 : 116.1

Ref: ST-EA-CP-M83011