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CAS 57432-61-8

:

Methergine

Description:
Methergine, known chemically as methylergometrine, is a semi-synthetic derivative of ergot alkaloids, primarily used in obstetrics to prevent or treat postpartum hemorrhage due to uterine atony. Its CAS number is 57432-61-8. Methergine acts as a potent uterine stimulant, promoting contractions and facilitating the expulsion of the placenta. The substance is typically administered via intramuscular or oral routes, depending on the clinical scenario. It has a relatively short half-life, necessitating careful monitoring of dosage and timing. Common side effects may include hypertension, nausea, and headache, reflecting its vasoconstrictive properties. Due to its pharmacological effects, Methergine is contraindicated in patients with hypertension or cardiovascular disease. Its mechanism of action involves agonistic activity at serotonin and adrenergic receptors, leading to increased uterine tone and reduced blood loss during and after childbirth. As with any medication, it is essential to use Methergine under medical supervision to ensure safety and efficacy.
Formula:C20H25N3O2·C4H4O4
InChI:InChI=1/C20H25N3O2.C4H4O4/c1-3-14(11-24)22-20(25)13-7-16-15-5-4-6-17-19(15)12(9-21-17)8-18(16)23(2)10-13;5-3(6)1-2-4(7)8/h4-7,9,13-14,18,21,24H,3,8,10-11H2,1-2H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/t13-,14+,18-;/m1./s1
InChI key:NOFOWWRHEPHDCY-DAUURJMHSA-N
SMILES:CN1[C@]2(C(C=3C=4C(C2)=CNC4C=CC3)=C[C@@H](C(N[C@@H](CC)CO)=O)C1)[H].C(=C\C(O)=O)\C(O)=O
Synonyms:
  • (8beta)-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-9,10-didehydroergoline-8-carboxamide (2Z)-but-2-enedioate (salt)
  • Basofortina
  • Erezin
  • Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8β)-, (2Z)-2-butenedioate (1:1) (salt)
  • Ergonovine, methyl-, compd. with maleic acid
  • Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv.
  • Metenarin
  • Methergin
  • Methergine
  • Methyl ergometrine maleate
  • See more synonyms
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