CAS 5746-90-7

3-Methylglutaconic acid

Description:

3-Methylglutaconic acid, with the CAS number 5746-90-7, is an organic compound characterized by its carboxylic acid functional groups and a branched-chain structure. It is a derivative of glutaconic acid, featuring a methyl group at the third carbon position. This compound is typically a colorless to pale yellow solid and is soluble in water due to the presence of its carboxylic acid groups. 3-Methylglutaconic acid is of particular interest in biochemical research, as it is associated with certain metabolic disorders, including 3-methylglutaconic aciduria, which can result from defects in mitochondrial function. The compound can participate in various chemical reactions, including esterification and decarboxylation, making it relevant in synthetic organic chemistry. Its molecular formula reflects its composition of carbon, hydrogen, and oxygen, and its structure allows for potential interactions with enzymes and other biological molecules. Overall, 3-methylglutaconic acid serves as an important compound in both clinical and synthetic contexts.

Formula: C₆H₈O₄

InChI: InChI=1S/C6H8O4/c1-4(2-5(7)8)3-6(9)10/h2H,3H2,1H3,(H,7,8)(H,9,10)

InChI key: InChIKey=WKRBKYFIJPGYQC-UHFFFAOYSA-N

SMILES: C(C(=CC(O)=O)C)C(O)=O

Synonyms:

• (2E)-3-Methyl-2-pentenedioic acid
• 2-Pentenedioic acid, 3-methyl-
• 2-pentenedioic acid, 3-methyl-, (2E)-
• 3-Methyl-2-pentenedioic acid
• 3-Methylglutaconic acid
• Glutaconic acid, 3-methyl-
• NSC 249232
• β-Methylglutaconic acid
• (2E)-3-Methylpent-2-enedioic acid

3-Methylglutaconic Acid

CAS: 5746-90-7

Formula: C₆H₈O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 144.1253

Ref: IN-DA00ED5Z

3-Methylglutaconic acid

CAS: 5746-90-7

3-Methylglutaconic acid

Purity: ≥95%

Ref: 54-OR1036762

3-Methylglutaconic Acid

CAS: 5746-90-7

Formula: C₆H₈O₄

Purity: >95.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 144.13

Ref: 3B-M3764

3-Methylglutaconic Acid

Controlled Product

CAS: 5746-90-7

Stability Hygroscopic
Applications 3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)
References Walsh, R., et al.: J. Inherit. Metab. Dis., 22, 251 (1999); Gonzalez, I., et al.: Am J Med Genet A., 134, 409 (2005); MacKenzie, J., et al.: Biochim Biophys Acta., 1772, 509 (2007)

Formula: C₆H₈O₄

Color and Shape: Neat

Molecular weight: 144.13

Ref: TR-M311565

3-Methylglutaconic acid

CAS: 5746-90-7

3-Methylglutaconic acid is a metabolite of creatine, which is an important energy source in the body. It is also involved in cholesterol synthesis and fatty acid production. The metabolic profile of 3-methylglutaconic acid can be used to diagnose metabolic disorders such as methylglutaconic aciduria and fatty acid oxidation defects. This compound can also be found in urine samples, but the concentration may vary depending on the patient's clinical condition. Nuclear DNA analysis has shown that 3-methylglutaconic acid is synthesized from acetyl coenzyme A and Mg2+, with the latter being supplied by ATP.

Formula: C₆H₈O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 144.13 g/mol

Ref: 3D-FM36321

3-Methylglutaconic acid

CAS: 5746-90-7

Purity: 97%

Molecular weight: 144.1260071

Ref: 10-F634807

3-Methylglutaconic acid

CAS: 5746-90-7

3-Methylglutaconic acid, a primary metabolite accumulating in 3-Methylglutaconic aciduria (MGTA), induces lipid and protein oxidation, while diminishing non-enzymatic antioxidant defenses in cerebral cortex supernatants, thereby promoting oxidative stress in the cerebral cortex. This compound is utilized in research concerning brain damage diseases [1].

Formula: C₆H₈O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 144.13

Ref: TM-T78071