CAS 57757-57-0

3,3′-Dithiobis(succinimidyl propionate)

Description:

3,3′-Dithiobis(succinimidyl propionate) (DTSP) is a crosslinking agent commonly used in bioconjugation and protein chemistry. It features a symmetrical structure with two succinimidyl propionate groups linked by a dithiobis (disulfide) bond, which allows for the formation of stable covalent bonds between proteins or other biomolecules. DTSP is particularly valued for its ability to facilitate the conjugation of proteins to surfaces or other molecules, enhancing the stability and functionality of the resulting complexes. The succinimidyl groups react with primary amines, making DTSP effective for labeling and immobilization applications. It is typically soluble in organic solvents and has a relatively low toxicity profile, although appropriate safety precautions should be taken during handling. The disulfide bond can be cleaved under reducing conditions, allowing for the release of the conjugated molecules if needed. Overall, DTSP is a versatile tool in biochemical research, particularly in the fields of immunology, diagnostics, and drug delivery systems.

Formula: C₁₄H₁₆N₂O₈S₂

InChI: InChI=1S/C14H16N2O8S2/c17-9-1-2-10(18)15(9)23-13(21)5-7-25-26-8-6-14(22)24-16-11(19)3-4-12(16)20/h1-8H2

InChI key: InChIKey=FXYPGCIGRDZWNR-UHFFFAOYSA-N

SMILES: O(C(CCSSCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)CCC2=O

Synonyms:

• (2,5-Dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate
• 1,1'-{Disulfanediylbis[(1-Oxopropane-3,1-Diyl)Oxy]}Dipyrrolidine-2,5-Dione
• 2,5-Pyrrolidinedione, 1,1′-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis-
• 3,3-Dithiodipropionic acid di(N-hydroxysuccinimide ester)
• 3,3-Dithiopropionic acid Di(N-succinimidyl ester)
• 3,3-dithio-bis(propionic acid N-*hydroxysuccinim
• 3,3′-Dithio(succinimidyl propionate)
• 3,3′-Dithiobis(N-hydroxysuccinimidylpropionate)
• 3,3′-Dithiobis(succinimidyl propionate)
• 3,3′-Dithioldipropionic acid bis(N-hydroxysuccinimide ester)
• Bis[2-[(succinimidyloxy)carbonyl]ethyl] disulfide
• Disuccinimidyl 3,3′-dithiobis(propionate)
• Dithiobis(succimidylpropionate)
• Dithiobis(succinimidylpropionate)
• Lomant's Reagent
• NSC 328386
• Propanoic acid, 3,3′-dithiobis-, 1,1′-bis(2,5-dioxo-1-pyrrolidinyl) ester

Bis(2,5-dioxopyrrolidin-1-yl) 3,3'-disulfanediyldipropanoate

CAS: 57757-57-0

Formula: C₁₄H₁₆N₂O₈S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 404.4154

Ref: IN-DA003IDW

DSP Crosslinker

CAS: 57757-57-0

DSP Crosslinker is a cleavable ADC linker, used in antibody-drug conjugates (ADCs) synthesis[1].

Formula: C₁₄H₁₆N₂O₈S₂

Purity: 97.89% - 99.94%

Color and Shape: Powder

Molecular weight: 404.42

Ref: TM-T15175

3,3''-Dithiodipropionic acid di(N-hydroxysuccinimide ester)

CAS: 57757-57-0

Formula: C₁₄H₁₆N₂O₈S₂

Molecular weight: 404.42

Ref: 7W-GX9784

DSP Crosslinker

CAS: 57757-57-0

DSP Crosslinker

Purity: ≥95%

Molecular weight: 404.42g/mol

Ref: 54-BUP11729

Dithiobis(succinimidyl propionate)

CAS: 57757-57-0

Dithiobis(succinimidyl propionate)

Formula: C₁₄H₁₆N₂O₈S₂

Purity: 97%

Color and Shape: white powder

Molecular weight: 404.41543g/mol

Ref: 54-BICL102

Di(N-succinimidyl) 3,3'-Dithiodipropionate [Cross-linking Reagent]

CAS: 57757-57-0

Formula: C₁₄H₁₆N₂O₈S₂

Purity: >97.0%(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 404.41

Ref: 3B-D2473

Di(N-succinimidyl) 3,3-Dithiodipropionate [Cross-linking Reagent]

CAS: 57757-57-0

Formula: C₁₄H₁₆N₂O₈S₂

Purity: 97%

Molecular weight: 404.41

Ref: 10-F544856

3,3'-Dithio(succinimidyl propionate)

Controlled Product

CAS: 57757-57-0

Applications Used in the crosslinking of intracellular proteins prior to cell lysis.

Formula: C₁₄H₁₆N₂O₈S₂

Color and Shape: Neat

Molecular weight: 404.42

Ref: TR-D494275

DSP

CAS: 57757-57-0

DSP is a widely used disulfide crosslinker in ADC synthesis. It forms reversible conjugates via intracellular reduction, enabling payload release.

Formula: C₁₄H₁₆N₂O₈S₂

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 404.42 g/mol

Ref: 3D-FD22555