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CAS 57757-57-0

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3,3′-Dithiobis(succinimidyl propionate)

Description:
3,3′-Dithiobis(succinimidyl propionate) (DTSP) is a crosslinking agent commonly used in bioconjugation and protein chemistry. It features a symmetrical structure with two succinimidyl propionate groups linked by a dithiobis (disulfide) bond, which allows for the formation of stable covalent bonds between proteins or other biomolecules. DTSP is particularly valued for its ability to facilitate the conjugation of proteins to surfaces or other molecules, enhancing the stability and functionality of the resulting complexes. The succinimidyl groups react with primary amines, making DTSP effective for labeling and immobilization applications. It is typically soluble in organic solvents and has a relatively low toxicity profile, although appropriate safety precautions should be taken during handling. The disulfide bond can be cleaved under reducing conditions, allowing for the release of the conjugated molecules if needed. Overall, DTSP is a versatile tool in biochemical research, particularly in the fields of immunology, diagnostics, and drug delivery systems.
Formula:C14H16N2O8S2
InChI:InChI=1S/C14H16N2O8S2/c17-9-1-2-10(18)15(9)23-13(21)5-7-25-26-8-6-14(22)24-16-11(19)3-4-12(16)20/h1-8H2
InChI key:InChIKey=FXYPGCIGRDZWNR-UHFFFAOYSA-N
SMILES:O(C(CCSSCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)CCC2=O
Synonyms:
  • (2,5-Dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate
  • 1,1'-{Disulfanediylbis[(1-Oxopropane-3,1-Diyl)Oxy]}Dipyrrolidine-2,5-Dione
  • 2,5-Pyrrolidinedione, 1,1′-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis-
  • 3,3-Dithiodipropionic acid di(N-hydroxysuccinimide ester)
  • 3,3-Dithiopropionic acid Di(N-succinimidyl ester)
  • 3,3-dithio-bis(propionic acid N-*hydroxysuccinim
  • 3,3′-Dithio(succinimidyl propionate)
  • 3,3′-Dithiobis(N-hydroxysuccinimidylpropionate)
  • 3,3′-Dithiobis(succinimidyl propionate)
  • 3,3′-Dithioldipropionic acid bis(N-hydroxysuccinimide ester)
  • See more synonyms
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