CAS 57808-65-8
:Closantel
Description:
Closantel is an anthelmintic agent primarily used in veterinary medicine for the treatment of parasitic infections in livestock, particularly in sheep and cattle. It belongs to the class of compounds known as salicylanilides and is effective against a range of nematodes and some cestodes. Closantel exhibits a broad spectrum of activity, particularly against gastrointestinal roundworms and lungworms. The compound is characterized by its lipophilic nature, which enhances its absorption and distribution in the body. It works by disrupting the energy metabolism of parasites, leading to their paralysis and eventual death. Closantel is typically administered orally or via injection, and its pharmacokinetics allow for prolonged efficacy, making it suitable for use in livestock management. Safety profiles indicate that it has a low toxicity to mammals, but care should be taken regarding its use in food-producing animals, as withdrawal periods are necessary to ensure that residues do not enter the food chain. Overall, Closantel is a valuable tool in veterinary parasitology, contributing to the health and productivity of livestock.
Formula:C22H14Cl2I2N2O2
InChI:InChI=1/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)
InChI key:InChIKey=JMPFSEBWVLAJKM-UHFFFAOYSA-N
SMILES:C(C#N)(C1=C(Cl)C=C(NC(=O)C2=C(O)C(I)=CC(I)=C2)C(C)=C1)C3=CC=C(Cl)C=C3
Synonyms:- 5'-Chloro-4'-(4-Chloro-Alpha-Cyanobenzyl)-3,5-Diiodo-2'-Methylsalicylanilide
- 5-Diiodo-Y-
- Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-
- Benzamide,N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydrox
- Closantel Base
- Clozantin
- Faskoverm
- Iodobenzamide
- N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydroxy-3,5-Di
- N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
- N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
- NSC 335306
- S 4105
- Seponver
- Zycloz
- Closantel
- CLOSANTEL(PATENT)
- N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide
- n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid
- N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE
- 5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide
- Closantelfreebase
- N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
- N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)
- N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE
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Closantel
CAS:Formula:C22H14Cl2I2N2O2Purity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:663.07Closantel
CAS:Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.Formula:C22H14Cl2I2N2O2Purity:98.52% - 99.86%Color and Shape:SolidMolecular weight:663.074N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-Diiodobenzamide
CAS:N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-DiiodobenzamideFormula:C22H14Cl2I2N2O2Purity:99%Molecular weight:663.07Closantel 100 µg/mL in Acetonitrile
CAS:Formula:C22H14Cl2I2N2O2Color and Shape:Single SolutionMolecular weight:663.07Closantel 1000 µg/mL in Acetonitrile
CAS:Controlled ProductFormula:C22H14Cl2I2N2O2Color and Shape:Single SolutionMolecular weight:663.07Closantel
CAS:Controlled ProductApplications Closantel is potentially useful for studying P-glycoprotein interactions in vitro.Closantel was used in preparation of Closantel-derived bacterial two-component system inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hlasta, D., et al.: Bioorg. Med. Chem. Lett., 8, 1923 (1998);Formula:C22H14Cl2I2N2O2Color and Shape:NeatMolecular weight:663.07N-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide
CAS:N-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamideFormula:C22H14Cl2I2N2O2Purity:99+%Molecular weight:663.07Closantel
CAS:Closantel is a drug that is used to treat worm infections. Closantel binds to the enzyme target and inhibits its function, leading to cell death. Closantel has been shown to be effective against resistant mutants in wastewater treatment, as well as in animal studies. The enzyme inhibitor activity of closantel can be measured by electrochemical impedance spectroscopy (EIS) and fluorescence detection. It also shows protein binding properties with anthelmintic drugs. This drug has been shown to have no significant toxicity for humans at therapeutic doses, and is not detectable in human serum or urine samples when taken orally. It has been detected in human serum after intravenous administration, but this route of administration should be avoided due to the risk of serious adverse effects.Formula:C22H14Cl2I2N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:663.07 g/molN-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide
CAS:Purity:98%Color and Shape:SolidMolecular weight:663.07
